SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		3 / 3 TRP A 109
ARG A   8
THR A 108
 None
None
GOL  A 205 ( 4.9A)
 1.01A 1df7A-3h0nA:
undetectable		 1df7A-3h0nA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		4 / 5 LEU A  15
CYH A 147
ALA A 149
CYH A 152
 None
ZN  A 201 ( 2.3A)
ZN  A 201 (-4.4A)
ZN  A 201 ( 2.3A)
 1.05A 1mz9D-3h0nA:
undetectable		 1mz9D-3h0nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		4 / 5 LEU A  15
ILE A  73
LEU A  76
SER A  77
 None
 0.93A 2byoA-3h0nA:
undetectable		 2byoA-3h0nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		4 / 8 THR A  22
THR A  71
ASP A 153
ILE A 146
 None
 0.89A 2qbmA-3h0nA:
undetectable		 2qbmA-3h0nA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		5 / 12 ALA A  49
LEU A 120
ASP A  47
LEU A  44
ILE A  37
 None
 1.13A 4ky8A-3h0nA:
undetectable		 4ky8A-3h0nA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		5 / 12 ALA A  49
LEU A 120
ASP A  47
LEU A  44
ILE A  37
 None
 1.12A 4ky8C-3h0nA:
undetectable		 4ky8C-3h0nA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		4 / 5 LEU A 132
ALA A  75
VAL A 155
ILE A 146
 None
 0.88A 4xe3A-3h0nA:
undetectable		 4xe3A-3h0nA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		3 / 3 ASN A 148
TYR A 156
CYH A 152
 None
None
ZN  A 201 ( 2.3A)
 0.95A 5lsuB-3h0nA:
undetectable		 5lsuB-3h0nA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		5 / 10 LEU A  65
LEU A  11
LEU A  76
ALA A  72
LEU A  88
 None
 1.10A 5y7pB-3h0nA:
undetectable		 5y7pB-3h0nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		5 / 10 LEU A  65
LEU A  11
LEU A  76
ALA A  72
LEU A  88
 None
 1.11A 5y7pH-3h0nA:
undetectable		 5y7pH-3h0nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		4 / 4 ALA A  72
ALA A  75
ALA A  84
ALA A  87
 None
 0.62A 6gtqA-3h0nA:
undetectable
6gtqB-3h0nA:
undetectable		 6gtqA-3h0nA:
21.29
6gtqB-3h0nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 3h0n UNCHARACTERIZED
PROTEIN DUF1470
(Jannaschia
sp.
CCS1) 		4 / 4 ALA A  84
ALA A  87
ALA A  72
ALA A  75
 None
 0.62A 6gtqA-3h0nA:
undetectable
6gtqB-3h0nA:
undetectable		 6gtqA-3h0nA:
21.29
6gtqB-3h0nA:
21.29