SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		5 / 9 VAL B 321
GLY B 318
ALA B 317
ILE B 307
GLU B 304
 None
 0.96A 1cetA-3h0rB:
undetectable		 1cetA-3h0rB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 8 CYH B  43
VAL B  42
CYH B  27
GLY B  26
 ZN  B 901 (-2.3A)
None
ZN  B 901 (-2.5A)
None
 0.93A 1ekjA-3h0rB:
undetectable
1ekjB-3h0rB:
undetectable		 1ekjA-3h0rB:
18.76
1ekjB-3h0rB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		5 / 12 ALA B 180
ARG B  63
ALA B  67
LEU B  68
ILE B  13
 None
 0.80A 1fk6A-3h0rB:
undetectable		 1fk6A-3h0rB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		5 / 10 LEU B 355
LEU B 351
ILE B 362
GLU B 370
LEU B 372
 None
 1.06A 1wopA-3h0rB:
undetectable		 1wopA-3h0rB:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		5 / 9 PHE B  78
LEU B 101
PHE B  24
MET B  23
LEU B 281
 None
 1.25A 1wrkA-3h0rB:
undetectable
1wrkB-3h0rB:
undetectable		 1wrkA-3h0rB:
9.83
1wrkB-3h0rB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 5 PHE B  78
LEU B 101
PHE B  24
MET B  23
 None
 1.26A 1wrkB-3h0rB:
undetectable		 1wrkB-3h0rB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		3 / 3 VAL B  72
SER B  65
LEU B 101
 None
 0.69A 3n8xA-3h0rB:
undetectable		 3n8xA-3h0rB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C
(Aquifex
aeolicus) 		5 / 9 ASP B 143
THR B  37
ASN B  36
GLY C  84
ASP C  83
 None
 1.15A 3sfuA-3h0rB:
undetectable		 3sfuA-3h0rB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 6 GLY B 342
PRO B 340
GLY B 311
TYR B 310
 None
 0.82A 4dxuA-3h0rB:
undetectable		 4dxuA-3h0rB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		3 / 3 PHE B 208
VAL B   8
GLU B   6
 None
ADP  B 479 (-4.8A)
None
 0.78A 4fvqA-3h0rB:
1.7		 4fvqA-3h0rB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		5 / 10 CYH B 194
LEU B  11
LEU B 170
ALA B 166
LEU B 227
 None
 1.19A 4p65A-3h0rB:
undetectable
4p65B-3h0rB:
undetectable
4p65F-3h0rB:
undetectable
4p65H-3h0rB:
undetectable		 4p65A-3h0rB:
8.43
4p65B-3h0rB:
4.83
4p65F-3h0rB:
4.83
4p65H-3h0rB:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 5 ARG B 201
ARG B 211
GLY B  10
GLU B  12
 None
ADP  B 479 (-3.0A)
ADP  B 479 (-3.4A)
MN  B 481 ( 2.8A)
 1.26A 4z3oA-3h0rB:
2.9
4z3oB-3h0rB:
2.8		 4z3oA-3h0rB:
22.67
4z3oB-3h0rB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 6 ARG B 201
ARG B 211
GLY B  10
GLU B  12
 None
ADP  B 479 (-3.0A)
ADP  B 479 (-3.4A)
MN  B 481 ( 2.8A)
 1.07A 5cdqA-3h0rB:
2.6
5cdqC-3h0rB:
2.5
5cdqD-3h0rB:
undetectable		 5cdqA-3h0rB:
22.22
5cdqC-3h0rB:
22.22
5cdqD-3h0rB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 4 CYH B 194
LEU B  11
LEU B 170
ALA B 166
 None
 1.10A 5hpuA-3h0rB:
undetectable
5hpuB-3h0rB:
undetectable		 5hpuA-3h0rB:
8.43
5hpuB-3h0rB:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		5 / 9 LEU B 372
ILE B 393
ARG B 356
GLU B 325
PHE B 329
 None
 1.43A 5igzA-3h0rB:
undetectable		 5igzA-3h0rB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		5 / 5 PRO B 369
ALA B 373
ALA B 333
ILE B 343
LEU B 347
 None
 1.19A 5jncD-3h0rB:
undetectable		 5jncD-3h0rB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 6 PHE B 329
VAL B 397
LEU B 375
LEU B 372
 None
 0.75A 6e43A-3h0rB:
undetectable		 6e43A-3h0rB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 6 PHE B 329
VAL B 397
LEU B 375
LEU B 372
 None
 0.82A 6e43B-3h0rB:
undetectable		 6e43B-3h0rB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 6 PHE B 329
VAL B 397
LEU B 375
LEU B 372
 None
 0.77A 6e43C-3h0rB:
undetectable		 6e43C-3h0rB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Aquifex
aeolicus) 		4 / 6 PHE B 329
VAL B 397
LEU B 375
LEU B 372
 None
 0.89A 6e43D-3h0rB:
undetectable		 6e43D-3h0rB:
22.31