SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 THR B  94
PRO B  91
GLY B 183
SER B 122
 None
 1.04A 3tzfB-3h0tB:
undetectable		 3tzfB-3h0tB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 LEU B  11
LYS B 126
PHE B 155
GLY B 183
 None
 0.97A 4hc3A-3h0tB:
undetectable		 4hc3A-3h0tB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 ARG B  70
ALA B  95
SER B  42
ARG B  45
 None
 0.83A 4lv9A-3h0tB:
undetectable
4lv9B-3h0tB:
undetectable		 4lv9A-3h0tB:
20.16
4lv9B-3h0tB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.91A 4qvyH-3h0tB:
undetectable		 4qvyH-3h0tB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.92A 4qvyV-3h0tB:
undetectable
4qvyW-3h0tB:
undetectable		 4qvyV-3h0tB:
22.01
4qvyW-3h0tB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.90A 5bxnH-3h0tB:
undetectable
5bxnI-3h0tB:
undetectable		 5bxnH-3h0tB:
22.01
5bxnI-3h0tB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.90A 5d0xV-3h0tB:
undetectable		 5d0xV-3h0tB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.87A 5l5fH-3h0tB:
undetectable
5l5fI-3h0tB:
undetectable		 5l5fH-3h0tB:
22.01
5l5fI-3h0tB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.87A 5l5fV-3h0tB:
undetectable
5l5fW-3h0tB:
undetectable		 5l5fV-3h0tB:
22.01
5l5fW-3h0tB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.97A 6hwdH-3h0tB:
undetectable
6hwdI-3h0tB:
undetectable		 6hwdH-3h0tB:
18.40
6hwdI-3h0tB:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER B 197
GLY B 143
THR B 144
ALA B 145
THR B 140
 None
 0.98A 6hwdV-3h0tB:
undetectable		 6hwdV-3h0tB:
18.40