SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 12 ARG A 132
PHE A 125
ALA A 118
LEU A 127
LEU A 103
 None
 1.20A 1og5A-3h0uA:
undetectable		 1og5A-3h0uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		4 / 8 LEU A 199
PHE A  27
LEU A 103
PHE A  69
 None
 0.90A 1wrlC-3h0uA:
undetectable
1wrlD-3h0uA:
undetectable		 1wrlC-3h0uA:
16.00
1wrlD-3h0uA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 121
GLY A 120
GLY A 122
ALA A 154
PHE A 100
 None
DMS  A   1 (-3.3A)
None
None
None
 1.09A 2c49A-3h0uA:
undetectable		 2c49A-3h0uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		4 / 5 ALA A 172
TRP A 189
LEU A 163
ALA A 169
 None
 1.29A 2jstA-3h0uA:
undetectable
2jstB-3h0uA:
undetectable		 2jstA-3h0uA:
13.72
2jstB-3h0uA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 10 GLU A 235
GLY A 153
ALA A 121
LEU A 160
ARG A 162
 None
 1.25A 3a3yA-3h0uA:
undetectable		 3a3yA-3h0uA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 12 GLN A 143
ALA A 156
GLN A 158
ARG A 101
LEU A 126
 None
 1.17A 4azwA-3h0uA:
undetectable		 4azwA-3h0uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 173
GLU A 124
GLY A 155
GLN A 105
HIS A 159
 None
 1.37A 4xucA-3h0uA:
undetectable		 4xucA-3h0uA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 173
GLU A 124
GLY A 155
GLN A 105
HIS A 159
 None
 1.40A 4xudA-3h0uA:
undetectable		 4xudA-3h0uA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 10 GLY A  36
ALA A  85
VAL A  40
ASP A  74
ILE A  35
 None
 1.22A 5i3cB-3h0uA:
undetectable		 5i3cB-3h0uA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 10 GLY A  36
ALA A  85
VAL A  40
GLU A  84
ILE A  35
 None
 1.02A 5i3cB-3h0uA:
undetectable		 5i3cB-3h0uA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 12 PHE A  27
ILE A  14
PHE A 125
THR A 110
LEU A 106
 None
 1.24A 5v5zA-3h0uA:
undetectable		 5v5zA-3h0uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		5 / 12 PHE A  27
ILE A  14
PHE A 125
THR A 110
LEU A 106
 None
 1.21A 6e8qA-3h0uA:
undetectable		 6e8qA-3h0uA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3h0u PUTATIVE ENOYL-COA
HYDRATASE
(Streptomyces
avermitilis) 		4 / 7 PHE A 264
LEU A 274
GLY A 120
GLY A  36
 None
None
DMS  A   1 (-3.3A)
None
 0.78A 6eu9D-3h0uA:
undetectable		 6eu9D-3h0uA:
13.45