SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 7 LEU A 446
TYR A 423
HIS A 443
THR A 270
 None
 1.28A 1afsA-3h11A:
undetectable		 1afsA-3h11A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 475
HIS A 443
LEU A 446
LEU A 424
TYR A 423
 None
 1.36A 1fm6D-3h11A:
undetectable		 1fm6D-3h11A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 5 HIS A 302
TYR A 305
TYR A 276
PRO A 250
 None
 1.37A 2ombA-3h11A:
undetectable
2ombB-3h11A:
undetectable		 2ombA-3h11A:
22.94
2ombB-3h11A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.11A 3ko0A-3h11A:
undetectable
3ko0B-3h11A:
undetectable
3ko0C-3h11A:
undetectable
3ko0D-3h11A:
undetectable		 3ko0A-3h11A:
15.79
3ko0B-3h11A:
15.79
3ko0C-3h11A:
15.79
3ko0D-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 6 LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 0.81A 3ko0B-3h11A:
undetectable		 3ko0B-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.24A 3ko0G-3h11A:
undetectable
3ko0H-3h11A:
undetectable
3ko0I-3h11A:
undetectable
3ko0J-3h11A:
undetectable		 3ko0G-3h11A:
15.79
3ko0H-3h11A:
15.79
3ko0I-3h11A:
15.79
3ko0J-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 11 LEU A 312
LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 1.09A 3ko0A-3h11A:
undetectable
3ko0B-3h11A:
undetectable
3ko0I-3h11A:
undetectable
3ko0J-3h11A:
undetectable		 3ko0A-3h11A:
15.79
3ko0B-3h11A:
15.79
3ko0I-3h11A:
15.79
3ko0J-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.13A 3ko0K-3h11A:
undetectable
3ko0L-3h11A:
undetectable
3ko0S-3h11A:
undetectable
3ko0T-3h11A:
undetectable		 3ko0K-3h11A:
15.79
3ko0L-3h11A:
15.79
3ko0S-3h11A:
15.79
3ko0T-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 312
LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 1.11A 3ko0K-3h11A:
undetectable
3ko0L-3h11A:
undetectable
3ko0M-3h11A:
undetectable
3ko0N-3h11A:
undetectable		 3ko0K-3h11A:
15.79
3ko0L-3h11A:
15.79
3ko0M-3h11A:
15.79
3ko0N-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 293
SER A 290
ILE A 257
CYH A 259
LEU A 312
 None
 1.12A 3ko0M-3h11A:
undetectable
3ko0N-3h11A:
undetectable
3ko0O-3h11A:
undetectable
3ko0P-3h11A:
undetectable		 3ko0M-3h11A:
15.79
3ko0N-3h11A:
15.79
3ko0O-3h11A:
15.79
3ko0P-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 312
LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 1.10A 3ko0M-3h11A:
undetectable
3ko0N-3h11A:
undetectable
3ko0O-3h11A:
undetectable
3ko0P-3h11A:
undetectable		 3ko0M-3h11A:
15.79
3ko0N-3h11A:
15.79
3ko0O-3h11A:
15.79
3ko0P-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 6 LEU A 293
SER A 290
ILE A 257
CYH A 259
 None
 0.87A 3ko0S-3h11A:
undetectable		 3ko0S-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 7 LEU A 477
TYR A 479
LEU A 274
TYR A 276
 None
 1.07A 4z4fA-3h11A:
4.2		 4z4fA-3h11A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 THR A 270
PHE A 271
LEU A 274
HIS A 302
PRO A 250
 None
 1.49A 5dlvA-3h11A:
undetectable		 5dlvA-3h11A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 7 ILE A 260
GLY A 261
PHE A 355
PHE A 271
 None
 0.88A 5hieA-3h11A:
undetectable		 5hieA-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 7 ILE A 260
GLY A 261
PHE A 355
PHE A 271
 None
 0.86A 5hieB-3h11A:
undetectable		 5hieB-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 7 ILE A 260
VAL A 309
PHE A 355
PHE A 271
 None
 0.99A 5hieC-3h11A:
undetectable		 5hieC-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 8 ILE A 260
GLY A 261
PHE A 355
PHE A 271
 None
 0.83A 5hieD-3h11A:
undetectable		 5hieD-3h11A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		4 / 7 LEU A 477
TYR A 479
LEU A 274
TYR A 276
 None
 1.01A 5t7bA-3h11A:
undetectable		 5t7bA-3h11A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR
(Homo
sapiens) 		5 / 12 ILE A 289
SER A 314
GLY A 330
ILE A 357
LEU A 333
 None
 1.06A 6dwnC-3h11A:
undetectable		 6dwnC-3h11A:
18.26