SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 7 PHE A 197
LEU A 111
ALA A 110
VAL A 252
VAL A 244
 None
 1.35A 1epbA-3h14A:
undetectable		 1epbA-3h14A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		3 / 3 PHE A 330
LEU A 357
MET A  36
 None
 0.80A 1mx1D-3h14A:
1.5		 1mx1D-3h14A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		3 / 3 SER A 199
THR A 176
GLN A 151
 None
None
GOL  A 502 (-3.2A)
 0.77A 2fk8A-3h14A:
3.8		 2fk8A-3h14A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		4 / 5 SER A 199
VAL A 224
SER A 169
VAL A 167
 None
None
None
GOL  A 502 (-3.9A)
 1.33A 2j9cA-3h14A:
0.5
2j9cB-3h14A:
0.4
2j9cC-3h14A:
undetectable		 2j9cA-3h14A:
14.58
2j9cB-3h14A:
14.58
2j9cC-3h14A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		3 / 3 SER A 196
ASP A 161
ASP A 116
 None
 0.67A 2plwA-3h14A:
undetectable		 2plwA-3h14A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		4 / 8 GLY A 124
ASN A 172
PHE A  14
TYR A 125
 GOL  A 502 ( 4.0A)
None
None
None
 1.36A 3ccfA-3h14A:
3.2		 3ccfA-3h14A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		3 / 3 TYR A 315
TYR A 125
GLY A  39
 None
 0.75A 3eteB-3h14A:
2.3
3eteD-3h14A:
2.4
3eteF-3h14A:
2.2		 3eteB-3h14A:
24.24
3eteD-3h14A:
24.24
3eteF-3h14A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		3 / 3 ASP A 326
ARG A 328
ALA A 329
 None
 0.80A 3mbgC-3h14A:
undetectable		 3mbgC-3h14A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 ILE A  15
ASP A  18
LEU A 357
ILE A  34
ILE A  33
 None
 1.10A 3pwwA-3h14A:
undetectable		 3pwwA-3h14A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 GLY A 205
GLY A 312
LEU A 281
ASN A 284
ASP A 278
 None
None
None
None
GOL  A 501 (-3.0A)
 1.17A 3r24A-3h14A:
2.0		 3r24A-3h14A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 THR A 144
LEU A 178
PHE A 197
VAL A 167
ALA A 185
 None
None
None
GOL  A 502 (-3.9A)
None
 1.37A 3u9fG-3h14A:
1.2
3u9fH-3h14A:
undetectable		 3u9fG-3h14A:
20.72
3u9fH-3h14A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 ILE A  77
ILE A 198
LEU A 111
GLY A 103
ILE A 225
 None
 0.94A 4o1eA-3h14A:
undetectable		 4o1eA-3h14A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 9 TYR A 125
PHE A 108
TYR A 128
GLY A 103
THR A  97
 None
 1.43A 4wmzA-3h14A:
undetectable		 4wmzA-3h14A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 10 PHE A 330
ALA A 318
ASP A 319
PHE A 304
SER A 321
 None
 1.41A 4xp1A-3h14A:
undetectable		 4xp1A-3h14A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 SER A 267
ALA A 273
GLU A 280
LEU A 281
THR A  43
 None
 1.49A 4zjoA-3h14A:
undetectable		 4zjoA-3h14A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		4 / 5 THR A 176
ALA A 171
THR A 174
TYR A 317
 None
GOL  A 502 (-3.5A)
None
None
 1.26A 5ecmA-3h14A:
1.7		 5ecmA-3h14A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 10 GLY A 102
GLY A  99
ILE A 198
LEU A 106
ALA A 107
 None
 0.98A 5l0zB-3h14A:
undetectable		 5l0zB-3h14A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 ILE A 202
ILE A 131
LEU A 132
VAL A 118
ILE A 120
 None
 1.02A 5mugA-3h14A:
undetectable		 5mugA-3h14A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 PHE A 232
LEU A  80
VAL A  94
VAL A 239
SER A 229
 GOL  A 501 (-4.7A)
GOL  A 501 (-4.2A)
None
None
None
 1.46A 5v1tA-3h14A:
undetectable		 5v1tA-3h14A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		4 / 5 TYR A 361
ARG A 292
MET A 295
LEU A 299
 None
 1.40A 5x19J-3h14A:
undetectable		 5x19J-3h14A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		4 / 5 TYR A 361
ARG A 292
MET A 295
LEU A 299
 None
 1.45A 5x1bJ-3h14A:
undetectable		 5x1bJ-3h14A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 PHE A 304
VAL A 316
ARG A 306
ILE A 307
ASP A 319
 None
 1.46A 6bxnA-3h14A:
2.3		 6bxnA-3h14A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 3h14 AMINOTRANSFERASE,
CLASSES I AND II
(Ruegeria
pomeroyi) 		5 / 12 ILE A 198
PHE A 108
LEU A 106
ASP A 200
ILE A 120
 None
 1.42A 6dwnB-3h14A:
undetectable		 6dwnB-3h14A:
10.97