SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3h15 PROTEIN MCM10
HOMOLOG
(Xenopus
laevis) 		5 / 11 PHE A 241
ASN A 346
LEU A 370
GLY A 343
PHE A 288
 None
 1.36A 1ju6A-3h15A:
undetectable		 1ju6A-3h15A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3h15 PROTEIN MCM10
HOMOLOG
(Xenopus
laevis) 		4 / 5 LEU A 317
CYH A 381
ALA A 383
CYH A 391
 None
ZN  A 500 (-2.4A)
ZN  A 500 ( 4.4A)
ZN  A 500 (-2.3A)
 1.10A 1mz9D-3h15A:
undetectable		 1mz9D-3h15A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3h15 PROTEIN MCM10
HOMOLOG
(Xenopus
laevis) 		5 / 10 VAL A 251
ILE A 246
GLY A 373
THR A 340
LEU A 370
 None
 1.11A 1z11D-3h15A:
undetectable		 1z11D-3h15A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3h15 PROTEIN MCM10
HOMOLOG
(Xenopus
laevis) 		5 / 11 HIS A 333
ILE A 342
LEU A 314
ASP A 374
GLY A 373
 None
 1.26A 4fogC-3h15A:
undetectable		 4fogC-3h15A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3h15 PROTEIN MCM10
HOMOLOG
(Xenopus
laevis) 		4 / 8 ASN A 346
ALA A 347
PRO A 349
LEU A 344
 None
 0.89A 4jjkA-3h15A:
undetectable		 4jjkA-3h15A:
16.76