SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 8 HIS C  98
LEU C 198
THR C 194
HIS C 197
 HEM  C 502 (-3.2A)
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.9A)
HEM  C 502 (-3.2A)
 1.06A 1azmA-3h1lC:
undetectable		 1azmA-3h1lC:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 10 ARG A 233
LEU A 163
LEU A 319
ALA A 157
GLY A 238
 None
 1.18A 1cmcA-3h1lA:
undetectable
1cmcB-3h1lA:
undetectable		 1cmcA-3h1lA:
14.29
1cmcB-3h1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.41A 1d4fC-3h1lC:
undetectable		 1d4fC-3h1lC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3h1l CYTOCHROME B
(Gallus
gallus) 		3 / 3 THR C 175
THR C 177
PRO C 174
 None
 0.84A 1dscC-3h1lC:
undetectable		 1dscC-3h1lC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3h1l CYTOCHROME B
(Gallus
gallus) 		6 / 12 ALA C 278
ILE C 281
MET C 125
LEU C 302
LEU C 329
LEU C 333
 3H1  C2001 ( 3.7A)
None
3H1  C2001 ( 4.7A)
HEM  C 502 ( 4.9A)
None
PEE  C2007 ( 4.0A)
 1.22A 1dtlA-3h1lC:
undetectable		 1dtlA-3h1lC:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		5 / 12 ALA B  36
VAL B  49
GLY B  48
ILE B  47
ILE B 382
 None
 0.93A 1fb7A-3h1lB:
undetectable		 1fb7A-3h1lB:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 6 ALA A 423
SER A 330
TRP A 342
LEU A 153
 None
 1.05A 1gahA-3h1lA:
undetectable		 1gahA-3h1lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 6 GLU A 393
LEU A 392
VAL A 366
MET A 365
 None
 0.90A 1hk1A-3h1lA:
undetectable		 1hk1A-3h1lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 7 GLU A 393
LEU A 392
VAL A 366
MET A 365
 None
 0.95A 1hk2A-3h1lA:
undetectable		 1hk2A-3h1lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 7 GLU A 393
LEU A 392
VAL A 366
MET A 365
 None
 0.94A 1hk3A-3h1lA:
undetectable		 1hk3A-3h1lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 8 HIS B 164
TYR B 168
LEU B 160
LEU B 172
 None
 0.88A 1i7zA-3h1lB:
undetectable		 1i7zA-3h1lB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 7 ALA A  96
TYR A  89
SER A  45
ALA A  43
 None
 1.07A 1k5qA-3h1lA:
undetectable
1k5qB-3h1lA:
1.0		 1k5qA-3h1lA:
18.78
1k5qB-3h1lA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
CYTOCHROME B
MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus;
Gallus
gallus;
Gallus
gallus) 		4 / 8 SER A 439
HIS C 222
PHE C 227
LYS D 226
 PEE  A2008 ( 4.1A)
PEE  A2008 (-4.1A)
None
None
 0.65A 1kb9A-3h1lA:
45.4
1kb9C-3h1lA:
undetectable
1kb9D-3h1lA:
undetectable
1kb9E-3h1lA:
undetectable		 1kb9A-3h1lA:
33.12
1kb9C-3h1lA:
21.04
1kb9D-3h1lA:
20.27
1kb9E-3h1lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 GLY A 169
GLY A  54
ASN A  53
THR A  90
TYR A 185
 None
 1.09A 1likA-3h1lA:
undetectable		 1likA-3h1lA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 ALA A 157
GLY A 238
ARG A 233
LEU A 163
LEU A 319
 None
 1.15A 1mj2A-3h1lA:
undetectable
1mj2B-3h1lA:
undetectable		 1mj2A-3h1lA:
14.29
1mj2B-3h1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 ALA A 157
GLY A 238
ARG A 233
LEU A 163
LEU A 319
 None
 1.16A 1mj2C-3h1lA:
undetectable
1mj2D-3h1lA:
undetectable		 1mj2C-3h1lA:
14.29
1mj2D-3h1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 ALA A 157
GLY A 238
ARG A 233
LEU A 163
LEU A 319
 None
 1.15A 1mjoC-3h1lA:
undetectable
1mjoD-3h1lA:
undetectable		 1mjoC-3h1lA:
14.29
1mjoD-3h1lA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus;
Gallus
gallus) 		5 / 9 VAL A 366
LEU A 392
LEU A   8
ARG A 362
ALA B  44
 None
 1.45A 1pbfA-3h1lA:
undetectable		 1pbfA-3h1lA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus) 		4 / 7 THR D 175
TYR D 171
ASN D 166
LEU D 169
 None
 1.04A 1qzrB-3h1lD:
undetectable		 1qzrB-3h1lD:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 7 PHE B 194
PHE B 199
SER B 100
ARG B  70
 None
 1.30A 1rqpB-3h1lB:
undetectable		 1rqpB-3h1lB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		5 / 12 PHE B 272
GLN B 276
SER B 319
ASN B 315
VAL B 258
 None
 1.34A 1u72A-3h1lB:
undetectable		 1u72A-3h1lB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		6 / 11 GLY C  87
ALA C  88
PHE C  91
ALA C 128
PHE C 275
LEU C 124
 None
HEM  C 501 ( 3.8A)
None
HEM  C 501 (-4.1A)
3H1  C2001 (-4.5A)
None
 1.48A 1ukbA-3h1lC:
undetectable		 1ukbA-3h1lC:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		5 / 12 ALA B 339
ALA B 340
GLN B 343
LEU B 295
HIS B 254
 None
 0.91A 1xiuB-3h1lB:
undetectable		 1xiuB-3h1lB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		3 / 3 PHE A  58
ARG A 165
ASN A  52
 None
 0.76A 1xzxX-3h1lA:
undetectable		 1xzxX-3h1lA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus) 		4 / 8 ASP F  40
THR C 372
TYR C 380
LEU C 378
 None
 1.00A 1z2bB-3h1lF:
undetectable		 1z2bB-3h1lF:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		3 / 3 GLY C 252
GLU C 272
ASN C 249
 UNL  C3106 ( 4.8A)
None
None
 0.56A 1zq9A-3h1lC:
undetectable		 1zq9A-3h1lC:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 5 ILE C 219
PRO C 220
PHE C 221
ILE C  28
 None
 0.79A 2hjhA-3h1lC:
undetectable		 2hjhA-3h1lC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 PHE A 216
ALA A 199
GLY A  38
GLY A  22
LEU A  23
 None
 1.07A 2hw2A-3h1lA:
undetectable		 2hw2A-3h1lA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 5 ASP A 226
SER A 220
LEU A  19
GLY A  22
 None
 1.09A 2j2pA-3h1lA:
undetectable
2j2pB-3h1lA:
undetectable		 2j2pA-3h1lA:
20.00
2j2pB-3h1lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 ASN A 359
ARG B  46
THR B 118
VAL B 119
SER A 363
 None
 1.38A 2o7oA-3h1lA:
undetectable		 2o7oA-3h1lA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		5 / 12 ILE B  35
LEU B  29
GLY B  32
ALA B 220
VAL B 219
 None
 0.98A 2oc8A-3h1lB:
undetectable		 2oc8A-3h1lB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 7 ILE B  35
ILE B 209
LEU B 379
ILE B 382
 None
 0.83A 2q83A-3h1lB:
0.7		 2q83A-3h1lB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 ILE C  95
PHE C  96
ILE C 301
ILE C 305
LEU C 122
 None
PEE  C2007 (-3.9A)
None
None
3H1  C2001 ( 4.8A)
 1.18A 2rlcA-3h1lC:
undetectable		 2rlcA-3h1lC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 7 PHE B 194
PHE B 199
SER B 100
ARG B  70
 None
 1.32A 2v7uB-3h1lB:
undetectable		 2v7uB-3h1lB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		3 / 3 ARG B  87
GLY B  88
SER A 363
 None
 0.66A 2xctB-3h1lB:
2.3		 2xctB-3h1lB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 VAL A 116
LEU A 113
THR A 373
THR A  36
ASN A  87
 None
 1.17A 3a35B-3h1lA:
undetectable		 3a35B-3h1lA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 ALA A 254
GLY A 321
LEU A 422
ARG A 242
PHE A 307
 None
 1.48A 3bxoB-3h1lA:
undetectable		 3bxoB-3h1lA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 8 ALA B  44
LEU B 112
GLN A 368
ILE A 390
 None
 0.84A 3cldB-3h1lB:
undetectable		 3cldB-3h1lB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		5 / 12 ALA B  36
VAL B  49
GLY B  48
ILE B  47
ILE B 382
 None
 0.86A 3ekwB-3h1lB:
undetectable		 3ekwB-3h1lB:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.34A 3glqA-3h1lC:
undetectable		 3glqA-3h1lC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 5 GLN B 376
THR B 374
THR B 367
HIS A  85
 None
 1.50A 3glqA-3h1lB:
undetectable		 3glqA-3h1lB:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.31A 3glqB-3h1lC:
undetectable		 3glqB-3h1lC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 5 GLN B 376
THR B 374
THR B 367
HIS A  85
 None
 1.50A 3glqB-3h1lB:
undetectable		 3glqB-3h1lB:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		3 / 3 MET A 334
MET A 343
PHE A 307
 None
 1.26A 3gn8A-3h1lA:
undetectable		 3gn8A-3h1lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 10 GLY C  49
GLN C  45
LEU C  51
LEU C  52
ILE C  80
 HEM  C 501 (-3.3A)
HEM  C 501 (-4.5A)
None
HEM  C 501 (-4.0A)
None
 1.00A 3kvrA-3h1lC:
undetectable		 3kvrA-3h1lC:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 10 GLY C  49
GLN C  45
LEU C  51
LEU C  52
ILE C  80
 HEM  C 501 (-3.3A)
HEM  C 501 (-4.5A)
None
HEM  C 501 (-4.0A)
None
 1.06A 3kvrB-3h1lC:
undetectable		 3kvrB-3h1lC:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 5 GLN B 376
THR B 374
THR B 367
HIS A  85
 None
 1.48A 3n58A-3h1lB:
undetectable		 3n58A-3h1lB:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 9 GLY C  49
GLN C  45
LEU C  51
LEU C  52
ILE C  80
 HEM  C 501 (-3.3A)
HEM  C 501 (-4.5A)
None
HEM  C 501 (-4.0A)
None
 1.02A 3nbqA-3h1lC:
undetectable		 3nbqA-3h1lC:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 9 GLY C  49
GLN C  45
LEU C  51
LEU C  52
ILE C  80
 HEM  C 501 (-3.3A)
HEM  C 501 (-4.5A)
None
HEM  C 501 (-4.0A)
None
 1.02A 3nbqD-3h1lC:
undetectable		 3nbqD-3h1lC:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 8 TYR B  99
GLN B 376
ALA B 375
LEU B 379
 None
 0.84A 3ozwA-3h1lB:
undetectable		 3ozwA-3h1lB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 5 LEU C 302
LEU C 103
GLY C 100
GLY C 102
 HEM  C 502 ( 4.9A)
None
PEE  C2007 ( 4.1A)
None
 0.80A 3si7C-3h1lC:
undetectable
3si7D-3h1lC:
undetectable		 3si7C-3h1lC:
22.76
3si7D-3h1lC:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus) 		5 / 12 GLY D 174
ASP D 173
SER D  25
GLU D 170
ALA D 177
 None
 1.23A 3t7sB-3h1lD:
undetectable		 3t7sB-3h1lD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus) 		5 / 12 GLY D 174
ASP D 173
SER D  25
GLU D 170
ALA D 177
 None
 1.22A 3t7sD-3h1lD:
undetectable		 3t7sD-3h1lD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 9 LEU A 303
ASP A 281
GLY A 278
ILE A 277
LEU A 297
 None
 1.09A 3u7sA-3h1lA:
undetectable		 3u7sA-3h1lA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 7 TRP B 135
PRO B 134
ARG B 133
PRO B 130
 None
 1.40A 3ucbB-3h1lB:
undetectable		 3ucbB-3h1lB:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		3 / 3 TYR B 181
GLU B 161
TYR B 177
 None
 0.95A 3ug8A-3h1lB:
undetectable		 3ug8A-3h1lB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3h1l CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 8 VAL B 314
VAL B 258
TYR B 325
LEU I  64
 None
 0.87A 3v81C-3h1lB:
3.0		 3v81C-3h1lB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus) 		3 / 3 ARG F 104
ARG F  49
ASP F  42
 None
 0.89A 3wipG-3h1lF:
undetectable
3wipH-3h1lF:
undetectable		 3wipG-3h1lF:
17.83
3wipH-3h1lF:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus;
Gallus
gallus) 		4 / 7 THR C 317
ASN C  27
LEU F  66
PHE C 318
 PEE  C2007 (-3.3A)
None
None
None
 1.34A 4awuA-3h1lC:
undetectable		 4awuA-3h1lC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 9 GLN A 368
VAL A 366
LEU A 392
LEU A   8
ILE A 399
 None
 1.21A 4c66A-3h1lA:
undetectable		 4c66A-3h1lA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 6 LEU C 241
LEU C  83
ILE C  80
THR C  44
 None
 1.00A 4do3B-3h1lC:
undetectable		 4do3B-3h1lC:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus) 		5 / 10 PHE D 189
ARG D 191
TRP D 192
ALA D 194
ALA D 101
 None
 1.39A 4fe1A-3h1lD:
undetectable
4fe1J-3h1lD:
undetectable		 4fe1A-3h1lD:
14.44
4fe1J-3h1lD:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 6 THR B  77
GLY B  79
ASN B 125
GLY B  88
 None
 0.90A 4fjpA-3h1lB:
undetectable		 4fjpA-3h1lB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B402_1
(PROTEASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 5 TRP B 135
PRO B 134
ARG B 133
PRO B 130
 None
 1.41A 4j5jB-3h1lB:
0.0		 4j5jB-3h1lB:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus) 		3 / 3 GLU D 124
ARG D 191
HIS D  14
 None
 0.85A 4kf9A-3h1lD:
undetectable		 4kf9A-3h1lD:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 GLY A 259
PRO A 260
GLY A 261
THR A 156
LEU A 153
 None
 0.89A 4n48A-3h1lA:
undetectable		 4n48A-3h1lA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 GLY A 259
PRO A 260
GLY A 261
THR A 156
LEU A 153
 None
 0.90A 4n49A-3h1lA:
undetectable		 4n49A-3h1lA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 5 ILE A 134
ASP A 142
GLU A 137
VAL A 167
 None
 1.24A 4nkxC-3h1lA:
undetectable		 4nkxC-3h1lA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 12 GLY C 143
VAL C 146
ILE C 147
ILE C 269
PRO C 271
TYR C 279
LEU C 282
 3H1  C2001 (-3.3A)
3H1  C2001 (-4.4A)
3H1  C2001 (-4.7A)
None
3H1  C2001 (-3.8A)
3H1  C2001 (-4.2A)
3H1  C2001 (-4.9A)
 0.61A 4pd4C-3h1lC:
52.8		 4pd4C-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 12 PHE C 129
GLY C 143
VAL C 146
ILE C 147
ILE C 269
PRO C 271
LEU C 282
 3H1  C2001 ( 4.7A)
3H1  C2001 (-3.3A)
3H1  C2001 (-4.4A)
3H1  C2001 (-4.7A)
None
3H1  C2001 (-3.8A)
3H1  C2001 (-4.9A)
 0.86A 4pd4C-3h1lC:
52.8		 4pd4C-3h1lC:
52.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3h1l CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 8 VAL B 314
VAL B 258
TYR B 325
LEU I  64
 None
 0.90A 4puoC-3h1lB:
4.1		 4puoC-3h1lB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3h1l CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 8 VAL B 314
VAL B 258
TYR B 325
LEU I  64
 None
 0.88A 4q0bA-3h1lB:
3.0		 4q0bA-3h1lB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		4 / 7 GLU A  48
THR A  90
GLY A  44
THR A  95
 None
 0.99A 4qwpB-3h1lA:
undetectable		 4qwpB-3h1lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus;
Gallus
gallus) 		5 / 12 ASN A 359
ARG B  46
THR B 118
VAL B 119
SER A 363
 None
 1.36A 4v2gB-3h1lA:
undetectable		 4v2gB-3h1lA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus) 		5 / 12 GLU F  39
ASP C 215
ARG C 314
ASN C 207
TYR C 110
 None
None
None
HEM  C 502 (-4.5A)
None
 1.36A 4wa5A-3h1lF:
undetectable		 4wa5A-3h1lF:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3h1l CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 8 GLY I  67
TYR B 107
SER B 100
SER B  73
 None
 0.94A 4wryA-3h1lI:
undetectable		 4wryA-3h1lI:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3h1l CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 8 GLY I  67
TYR B 107
SER B 100
SER B  73
 None
 0.91A 4wrzA-3h1lI:
undetectable		 4wrzA-3h1lI:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		4 / 5 LEU B 430
ALA B 425
ASN B 162
ILE B 244
 None
 1.14A 4y03B-3h1lB:
undetectable		 4y03B-3h1lB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 VAL C 299
LEU C 302
ILE C  99
ILE C  95
MET C 125
 None
HEM  C 502 ( 4.9A)
HEM  C 502 (-3.9A)
None
3H1  C2001 ( 4.7A)
 0.82A 4y0rA-3h1lC:
undetectable		 4y0rA-3h1lC:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus) 		3 / 3 THR D  55
HIS D  41
LEU D 190
 None
HEC  D 501 (-3.2A)
None
 0.77A 5axdA-3h1lD:
undetectable		 5axdA-3h1lD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus) 		3 / 3 THR D  55
HIS D  41
LEU D 190
 None
HEC  D 501 (-3.2A)
None
 0.78A 5axdC-3h1lD:
undetectable		 5axdC-3h1lD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus;
Gallus
gallus) 		4 / 6 TYR F  20
GLY C 371
SER C 322
LEU C 321
 None
 1.20A 5bphA-3h1lF:
undetectable		 5bphA-3h1lF:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus;
Gallus
gallus) 		4 / 7 TYR F  20
GLY C 371
SER C 322
LEU C 321
 None
 1.07A 5bphB-3h1lF:
undetectable		 5bphB-3h1lF:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus;
Gallus
gallus) 		4 / 4 TYR F  20
GLY C 371
SER C 322
LEU C 321
 None
 1.19A 5bphC-3h1lF:
undetectable		 5bphC-3h1lF:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus;
Gallus
gallus) 		4 / 6 TYR F  20
GLY C 371
SER C 322
LEU C 321
 None
 1.17A 5bphD-3h1lF:
undetectable		 5bphD-3h1lF:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		3 / 3 ASP A 144
GLU A 168
SER A 306
 None
 0.86A 5bw4B-3h1lA:
undetectable		 5bw4B-3h1lA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus;
Gallus
gallus) 		3 / 3 ASP B 114
GLU B  39
SER A 400
 None
 0.83A 5bw4B-3h1lB:
undetectable		 5bw4B-3h1lB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3h1l CYTOCHROME B
MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
C REDUCTASE 14 KDA
PROTEIN
(Gallus
gallus;
Gallus
gallus) 		5 / 12 GLY C 211
ARG C 314
TYR F  38
TYR F  29
LEU F  31
 None
 1.24A 5czyA-3h1lC:
undetectable		 5czyA-3h1lC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3h1l CYTOCHROME B
MITOCHONDRIAL
CYTOCHROME C1, HEME
PROTEIN
(Gallus
gallus;
Gallus
gallus) 		3 / 3 TRP C  78
ARG D 201
LEU C  83
 None
 0.69A 5dbyA-3h1lC:
undetectable		 5dbyA-3h1lC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		3 / 3 SER B 310
LEU B 439
MET B 341
 None
 0.59A 5ikrB-3h1lB:
undetectable		 5ikrB-3h1lB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 7 HIS C 268
ILE C 269
TYR C 279
ARG C 283
 None
None
3H1  C2001 (-4.2A)
None
 0.89A 5kkzC-3h1lC:
undetectable
5kkzE-3h1lC:
48.7		 5kkzC-3h1lC:
16.71
5kkzE-3h1lC:
44.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 7 HIS C 268
ILE C 269
TYR C 279
ARG C 283
 None
None
3H1  C2001 (-4.2A)
None
 0.91A 5kkzK-3h1lC:
48.3
5kkzQ-3h1lC:
undetectable		 5kkzK-3h1lC:
44.82
5kkzQ-3h1lC:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3h1l CYTOCHROME B
(Gallus
gallus) 		4 / 7 HIS C 268
ILE C 269
TYR C 279
ARG C 283
 None
None
3H1  C2001 (-4.2A)
None
 0.93A 5kkzM-3h1lC:
undetectable
5kkzO-3h1lC:
48.7		 5kkzM-3h1lC:
16.71
5kkzO-3h1lC:
44.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
(Gallus
gallus;
Gallus
gallus) 		5 / 12 ALA B  66
ILE I  68
GLY I  67
THR B 101
SER B 100
 None
 1.13A 5nfjB-3h1lB:
undetectable		 5nfjB-3h1lB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
(Gallus
gallus;
Gallus
gallus) 		5 / 12 ILE I  68
GLY I  67
THR B 101
SER B 100
LEU B 144
 None
 1.21A 5nfjB-3h1lI:
undetectable		 5nfjB-3h1lI:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
(Gallus
gallus;
Gallus
gallus) 		5 / 12 ALA B  66
ILE I  68
GLY I  67
THR B 101
SER B 100
 None
 1.13A 5nfjC-3h1lB:
undetectable		 5nfjC-3h1lB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL
(Gallus
gallus;
Gallus
gallus) 		5 / 12 ILE I  68
GLY I  67
THR B 101
SER B 100
LEU B 144
 None
 1.22A 5nfjC-3h1lI:
undetectable		 5nfjC-3h1lI:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 SER A  81
VAL A  79
ALA A 101
ALA A  84
GLY A  83
 None
 1.14A 5tzoA-3h1lA:
undetectable		 5tzoA-3h1lA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		5 / 12 SER A  81
VAL A  79
ALA A 101
ALA A  84
GLY A  83
 None
 1.12A 5tzoC-3h1lA:
undetectable		 5tzoC-3h1lA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I
(Gallus
gallus) 		3 / 3 GLU A 172
HIS A 176
ARG A 131
 None
 0.82A 5uunA-3h1lA:
undetectable		 5uunA-3h1lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2
(Gallus
gallus) 		5 / 12 ALA B 339
ALA B 340
GLN B 343
LEU B 295
HIS B 254
 None
 1.02A 6a60D-3h1lB:
undetectable		 6a60D-3h1lB:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 LEU C  42
LEU C 198
GLY C  35
HIS C  98
PHE C  91
 None
3H1  C2002 ( 4.0A)
HEM  C 502 (-3.2A)
HEM  C 502 (-3.2A)
None
 1.27A 6aphA-3h1lC:
undetectable		 6aphA-3h1lC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3h1l CYTOCHROME B
(Gallus
gallus) 		5 / 12 GLY C 102
ILE C  46
PHE C  91
THR C 123
LEU C 120
 None
None
None
None
HEM  C 502 (-3.4A)
 1.24A 6e8qA-3h1lC:
undetectable		 6e8qA-3h1lC:
12.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 10 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 315
PHE C 326
VAL C 330
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
None
PEE  C2007 ( 4.8A)
PEE  C2007 ( 4.7A)
 1.37A 6hu9C-3h1lC:
5.3		 6hu9C-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 10 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 317
PHE C 326
VAL C 330
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
PEE  C2007 (-3.3A)
PEE  C2007 ( 4.8A)
PEE  C2007 ( 4.7A)
 0.39A 6hu9C-3h1lC:
5.3		 6hu9C-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 12 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 315
VAL C 330
TYR C 359
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
None
PEE  C2007 ( 4.7A)
None
 1.42A 6hu9N-3h1lC:
undetectable		 6hu9N-3h1lC:
52.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 3h1l CYTOCHROME B
(Gallus
gallus) 		7 / 12 TRP C  31
PHE C  96
TYR C 104
TYR C 105
THR C 317
VAL C 330
TYR C 359
 PEE  C2007 ( 3.1A)
PEE  C2007 (-3.9A)
PEE  C2007 (-3.5A)
PEE  C2007 ( 4.3A)
PEE  C2007 (-3.3A)
PEE  C2007 ( 4.7A)
None
 0.43A 6hu9N-3h1lC:
undetectable		 6hu9N-3h1lC:
52.82