SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h1v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 12 VAL X 154
LEU X  79
SER X 445
ILE X 126
PHE X  84
 None
 1.32A 1skxA-3h1vX:
undetectable		 1skxA-3h1vX:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3h1v GLUCOKINASE
(Homo
sapiens) 		3 / 3 MET X  37
ASN X 231
GLN X 287
 None
GLC  X 500 (-3.8A)
GLC  X 500 (-4.2A)
 0.90A 1xoqB-3h1vX:
undetectable		 1xoqB-3h1vX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 10 ARG X 191
GLY X 117
THR X 118
ALA X 119
ALA X 173
 None
 1.15A 2ej3B-3h1vX:
undetectable		 2ej3B-3h1vX:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 12 PHE X 423
VAL X 408
THR X 255
ALA X 232
ILE X 390
 None
 1.21A 2qm9B-3h1vX:
undetectable		 2qm9B-3h1vX:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 8 GLY X  72
SER X 453
ALA X 454
CYH X 457
 None
 0.77A 2vh3B-3h1vX:
undetectable		 2vh3B-3h1vX:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 9 ARG X 368
VAL X 367
ILE X 348
ILE X 351
GLN X 337
 None
 1.50A 3hgxB-3h1vX:
0.9		 3hgxB-3h1vX:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 6 ARG X 308
TYR X 273
PHE X  23
LEU X  20
 None
 1.29A 3tgvB-3h1vX:
undetectable		 3tgvB-3h1vX:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 5 ARG X 308
TYR X 273
PHE X  23
LEU X  20
 None
 1.33A 3tgvC-3h1vX:
undetectable		 3tgvC-3h1vX:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 6 CYH X 233
ASN X 254
CYH X 252
ILE X 211
 None
GLC  X 500 ( 4.6A)
None
TK1  X 501 (-4.3A)
 1.34A 3w9tB-3h1vX:
undetectable		 3w9tB-3h1vX:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 12 VAL X 181
ALA X 176
LEU X 122
PHE X 171
SER X 151
 None
None
None
None
GLC  X 500 (-4.5A)
 1.26A 4eckA-3h1vX:
undetectable		 4eckA-3h1vX:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 6 GLY X 229
GLY X 227
GLU X 290
ILE X 293
 GLC  X 500 ( 3.8A)
None
GLC  X 500 (-3.1A)
None
 0.86A 4fglD-3h1vX:
undetectable		 4fglD-3h1vX:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 12 GLY X 407
ASP X 217
ILE X 225
GLY X 410
ARG X 447
 None
None
GLC  X 500 ( 4.1A)
None
None
 1.28A 4obwC-3h1vX:
undetectable		 4obwC-3h1vX:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 9 ALA X 201
ALA X 456
ALA X 454
ALA X 449
SER X  76
 None
TK1  X 501 ( 4.5A)
None
None
None
 1.21A 4twdA-3h1vX:
undetectable
4twdB-3h1vX:
undetectable
4twdC-3h1vX:
undetectable
4twdD-3h1vX:
undetectable
4twdE-3h1vX:
undetectable		 4twdA-3h1vX:
18.98
4twdB-3h1vX:
18.98
4twdC-3h1vX:
18.98
4twdD-3h1vX:
18.98
4twdE-3h1vX:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3h1v GLUCOKINASE
(Homo
sapiens) 		5 / 11 ILE X 225
GLY X 410
ASP X 205
GLU X 290
THR X 206
 GLC  X 500 ( 4.1A)
None
GLC  X 500 (-2.9A)
GLC  X 500 (-3.1A)
GLC  X 500 ( 4.2A)
 1.46A 4xt7A-3h1vX:
undetectable		 4xt7A-3h1vX:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3h1v GLUCOKINASE
(Homo
sapiens) 		3 / 3 ASP X 409
ASN X 231
PHE X 152
 None
GLC  X 500 (-3.8A)
None
 0.78A 5dsgB-3h1vX:
undetectable		 5dsgB-3h1vX:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 7 VAL X 374
SER X 375
ALA X 378
GLY X 294
 None
 0.84A 5fpdA-3h1vX:
14.0		 5fpdA-3h1vX:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 7 VAL X 374
SER X 375
ALA X 378
GLY X 294
 None
 0.84A 5fpdB-3h1vX:
0.0		 5fpdB-3h1vX:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h1v GLUCOKINASE
(Homo
sapiens) 		3 / 3 LEU X  45
TYR X 234
SER X 396
 None
 0.89A 5iktA-3h1vX:
undetectable		 5iktA-3h1vX:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 8 GLY X 264
GLY X 261
LEU X 288
ALA X 259
 None
 0.73A 5vw5A-3h1vX:
undetectable		 5vw5A-3h1vX:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 8 ARG X 377
ASP X 262
LEU X 288
GLY X 261
 None
 0.83A 5x5qF-3h1vX:
undetectable		 5x5qF-3h1vX:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3h1v GLUCOKINASE
(Homo
sapiens) 		4 / 7 ASP X 205
GLY X 295
GLY X 227
VAL X 412
 GLC  X 500 (-2.9A)
None
None
None
 0.97A 6ekzA-3h1vX:
undetectable		 6ekzA-3h1vX:
10.59