SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		3 / 3 GLN A  97
HIS A 255
PRO A 254
 Y1  A 398 ( 4.9A)
ZN  A 397 (-3.2A)
None
 0.95A 1d8cA-3h1wA:
undetectable		 1d8cA-3h1wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		5 / 11 LEU A  58
LEU A  81
LEU A  70
SER A 339
ALA A 341
 None
 1.10A 1h9zA-3h1wA:
undetectable		 1h9zA-3h1wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 7 LEU A 325
PHE A 344
PHE A 323
PHE A  85
 None
 0.95A 1wrlE-3h1wA:
undetectable
1wrlF-3h1wA:
undetectable		 1wrlE-3h1wA:
11.83
1wrlF-3h1wA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		5 / 12 LEU A 352
LEU A 384
HIS A 326
ILE A 342
ALA A 341
 None
 1.07A 2bxcA-3h1wA:
undetectable		 2bxcA-3h1wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		5 / 10 LEU A  81
PHE A  83
LEU A  58
LEU A   4
ILE A 342
 None
 1.08A 2bxeB-3h1wA:
2.1		 2bxeB-3h1wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 7 GLU A 347
GLY A 244
PHE A 323
PHE A  85
 None
 1.03A 2qmzA-3h1wA:
undetectable
2qmzB-3h1wA:
undetectable		 2qmzA-3h1wA:
22.36
2qmzB-3h1wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 GLY A 276
LEU A 187
PHE A 184
PHE A 148
 EDO  A 393 ( 3.7A)
EDO  A 394 ( 4.0A)
EDO  A 394 (-4.3A)
None
 0.76A 2vctA-3h1wA:
undetectable		 2vctA-3h1wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 GLY A 276
LEU A 187
PHE A 184
PHE A 148
 EDO  A 393 ( 3.7A)
EDO  A 394 ( 4.0A)
EDO  A 394 (-4.3A)
None
 0.72A 2vctB-3h1wA:
undetectable		 2vctB-3h1wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 7 GLY A 276
LEU A 187
PHE A 184
PHE A 148
 EDO  A 393 ( 3.7A)
EDO  A 394 ( 4.0A)
EDO  A 394 (-4.3A)
None
 0.77A 2vctD-3h1wA:
undetectable		 2vctD-3h1wA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 ILE A 335
PHE A 344
PHE A  85
PHE A 323
 None
 0.80A 3ko0B-3h1wA:
undetectable
3ko0J-3h1wA:
undetectable		 3ko0B-3h1wA:
12.28
3ko0J-3h1wA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 ILE A 335
PHE A 344
PHE A  85
PHE A 323
 None
 0.76A 3ko0K-3h1wA:
undetectable
3ko0S-3h1wA:
undetectable		 3ko0K-3h1wA:
12.28
3ko0S-3h1wA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 PHE A 323
ILE A 335
PHE A 344
PHE A  85
 None
 0.74A 3ko0O-3h1wA:
undetectable
3ko0Q-3h1wA:
undetectable		 3ko0O-3h1wA:
12.28
3ko0Q-3h1wA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		3 / 3 SER A  46
GLY A  39
SER A 366
 None
None
EDO  A 396 ( 4.8A)
 0.69A 3loqA-3h1wA:
undetectable		 3loqA-3h1wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 6 PHE A  78
ASN A 389
PHE A 321
ALA A 322
 None
 1.17A 3t3sB-3h1wA:
undetectable		 3t3sB-3h1wA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		5 / 12 ILE A 316
ALA A 385
PHE A 323
LEU A 139
VAL A 346
 None
 1.19A 3w67C-3h1wA:
undetectable		 3w67C-3h1wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 5 LEU A  88
HIS A 255
GLU A 134
HIS A  99
 None
ZN  A 397 (-3.2A)
ZN  A 397 ( 2.3A)
ZN  A 397 (-3.3A)
 1.29A 4a7bB-3h1wA:
undetectable		 4a7bB-3h1wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		3 / 3 ARG A 386
HIS A 326
TYR A 388
 None
 1.02A 4fu8A-3h1wA:
undetectable		 4fu8A-3h1wA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		3 / 3 ARG A 386
HIS A 326
TYR A 388
 None
 1.10A 4fu9A-3h1wA:
undetectable		 4fu9A-3h1wA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 7 GLU A 134
HIS A  99
VAL A 136
GLU A 264
 ZN  A 397 ( 2.3A)
ZN  A 397 (-3.3A)
None
Y1  A 398 (-2.6A)
 0.99A 4hvrA-3h1wA:
4.8		 4hvrA-3h1wA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 GLY A 192
GLN A 191
SER A 196
SER A 228
 None
None
None
EDO  A 393 ( 3.5A)
 1.00A 4ws1A-3h1wA:
undetectable		 4ws1A-3h1wA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		5 / 12 LEU A 235
LEU A 187
MET A 190
ALA A 198
VAL A 161
 None
EDO  A 394 ( 4.0A)
None
None
None
 1.14A 4x1yB-3h1wA:
undetectable		 4x1yB-3h1wA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 PRO A 305
PHE A 314
SER A 324
TYR A 388
 None
 1.27A 5amiB-3h1wA:
undetectable		 5amiB-3h1wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 6 LEU A 325
SER A 324
PHE A 314
ASP A 313
 None
 1.15A 5om3A-3h1wA:
undetectable
5om3B-3h1wA:
undetectable		 5om3A-3h1wA:
13.08
5om3B-3h1wA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3h1w MANNOSE-6-PHOSPHATE
ISOMERASE
(Salmonella
enterica) 		4 / 8 VAL A   8
ASN A  10
GLN A  30
PRO A  32
 None
 1.09A 6hzpA-3h1wA:
undetectable		 6hzpA-3h1wA:
23.05