SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3h25 REPLICATION PROTEIN
B
(Plasmid
RSF1010) 		5 / 12 PHE A  22
LEU A  45
ALA A  41
GLY A  11
LEU A  73
 None
 1.01A 1kglA-3h25A:
undetectable		 1kglA-3h25A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3h25 REPLICATION PROTEIN
B
(Plasmid
RSF1010) 		4 / 5 VAL A 166
THR A 100
GLN A 106
ILE A  63
 None
 1.44A 1ss4A-3h25A:
undetectable		 1ss4A-3h25A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3h25 REPLICATION PROTEIN
B
(Plasmid
RSF1010) 		4 / 8 LEU A  51
LYS A  52
ASN A  55
ARG A 145
 None
 0.67A 2xn3A-3h25A:
undetectable
2xn3B-3h25A:
undetectable		 2xn3A-3h25A:
18.60
2xn3B-3h25A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3h25 REPLICATION PROTEIN
B
(Plasmid
RSF1010) 		4 / 7 ARG A 145
GLY A  11
ILE A  10
VAL A  98
 None
 0.79A 3ufnB-3h25A:
undetectable		 3ufnB-3h25A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3h25 REPLICATION PROTEIN
B
(Plasmid
RSF1010) 		5 / 10 ILE A  24
ALA A  66
LEU A  96
ILE A  63
TYR A 143
 None
 1.31A 4km0A-3h25A:
undetectable		 4km0A-3h25A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3h25 REPLICATION PROTEIN
B
(Plasmid
RSF1010) 		5 / 12 GLY A  72
ILE A 123
LEU A 119
GLY A 179
GLY A 173
 None
 1.06A 5d4uB-3h25A:
undetectable		 5d4uB-3h25A:
21.18