SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 194
ALA A 249
PHE A 231
VAL A 233
 None
 0.73A 1epbA-3h2bA:
undetectable		 1epbA-3h2bA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 LEU A 194
ALA A 249
PHE A 231
VAL A 233
 None
 0.78A 1epbB-3h2bA:
undetectable		 1epbB-3h2bA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 LEU A 163
GLU A 189
ALA A 251
LEU A 194
 None
 0.98A 1eta1-3h2bA:
undetectable		 1eta1-3h2bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 LEU A 163
GLU A 189
ALA A 251
LEU A 194
 None
 1.04A 1eta2-3h2bA:
undetectable		 1eta2-3h2bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 LEU A 163
GLU A 189
ALA A 251
LEU A 194
 None
 0.99A 1etb1-3h2bA:
undetectable		 1etb1-3h2bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		6 / 12 GLY A 108
GLY A 106
LEU A  77
ALA A  73
VAL A 133
LEU A 132
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.7A)
None
None
SAH  A 301 ( 4.9A)
 1.48A 2yqzA-3h2bA:
15.0		 2yqzA-3h2bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		6 / 12 GLY A 108
GLY A 106
LEU A  77
ALA A  73
VAL A 133
LEU A 132
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.7A)
None
None
SAH  A 301 ( 4.9A)
 1.48A 2yqzB-3h2bA:
15.1		 2yqzB-3h2bA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 GLY A 108
THR A 109
GLU A 127
ASP A 104
 SAH  A 301 (-3.4A)
None
SAH  A 301 (-2.6A)
SAH  A 301 ( 4.4A)
 0.94A 3ps9A-3h2bA:
5.1		 3ps9A-3h2bA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A 241
PHE A 242
PRO A 243
 None
 0.47A 3zoaB-3h2bA:
undetectable		 3zoaB-3h2bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 TRP A 112
VAL A 105
TRP A 166
 None
 1.14A 3zq8A-3h2bA:
undetectable
3zq8B-3h2bA:
undetectable		 3zq8A-3h2bA:
8.15
3zq8B-3h2bA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 233
LEU A 194
ALA A 165
LEU A 247
LEU A 177
 None
 1.14A 4i1rA-3h2bA:
undetectable		 4i1rA-3h2bA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 TYR A  66
GLY A 106
PRO A 128
ALA A 129
ILE A 150
 SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.1A)
 1.01A 4rvdA-3h2bA:
16.0		 4rvdA-3h2bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 8 LEU A 169
LEU A 181
LEU A 226
ALA A 249
ALA A 165
 None
 1.09A 4z90A-3h2bA:
undetectable
4z90B-3h2bA:
undetectable
4z90C-3h2bA:
undetectable
4z90D-3h2bA:
undetectable
4z90E-3h2bA:
undetectable		 4z90A-3h2bA:
21.43
4z90B-3h2bA:
21.43
4z90C-3h2bA:
21.43
4z90D-3h2bA:
21.43
4z90E-3h2bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 102
ALA A 161
ALA A 187
ARG A 185
LEU A 163
 None
 1.42A 4zo1X-3h2bA:
undetectable		 4zo1X-3h2bA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 106
GLY A 108
PRO A 128
ALA A 129
ILE A 150
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.1A)
 0.67A 5bw4B-3h2bA:
6.5		 5bw4B-3h2bA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 SER A 142
VAL A 143
GLY A 114
ALA A 117
 None
 0.94A 5k50A-3h2bA:
5.9		 5k50A-3h2bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 VAL A 105
GLY A 106
GLU A 127
SER A 168
LEU A 169
 None
SAH  A 301 (-3.4A)
SAH  A 301 (-2.6A)
SAH  A 301 (-4.7A)
None
 1.16A 5x6yC-3h2bA:
7.2		 5x6yC-3h2bA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A  88
ILE A  81
SER A  82
 None
 0.86A 5zw2A-3h2bA:
undetectable		 5zw2A-3h2bA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 3h2b SAM-DEPENDENT
METHYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 105
ASP A 104
LEU A 222
PHE A 231
LEU A 226
 None
SAH  A 301 ( 4.4A)
None
None
None
 1.15A 6ew0G-3h2bA:
undetectable		 6ew0G-3h2bA:
20.00