SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 8 ASP A 133
SER A  71
VAL A  72
GLY A  75
GLY A  77
 None
NDP  A 301 (-3.2A)
None
None
None
 1.48A 1aq7A-3h2sA:
undetectable		 1aq7A-3h2sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 11 LEU A  53
LEU A  55
ALA A  65
ALA A   4
LEU A  70
 None
None
None
None
NDP  A 301 (-4.4A)
 1.22A 1iiuA-3h2sA:
undetectable		 1iiuA-3h2sA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		3 / 3 ASP A  68
LEU A  81
LEU A  70
 None
NDP  A 301 (-4.9A)
NDP  A 301 (-4.4A)
 0.75A 1ikeA-3h2sA:
undetectable		 1ikeA-3h2sA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 9 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.17A 1pxxB-3h2sA:
undetectable		 1pxxB-3h2sA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 10 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.17A 1pxxD-3h2sA:
undetectable		 1pxxD-3h2sA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 7 LEU A 200
ASP A  64
THR A  98
HIS A  88
 None
 1.06A 1v55C-3h2sA:
undetectable
1v55N-3h2sA:
undetectable
1v55P-3h2sA:
undetectable		 1v55C-3h2sA:
22.46
1v55N-3h2sA:
17.81
1v55P-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		6 / 12 GLY A   7
ALA A  69
ASP A  68
ILE A 196
ALA A  20
ILE A  16
 NDP  A 301 (-3.2A)
NDP  A 301 (-4.9A)
None
None
None
None
 1.46A 2rkfB-3h2sA:
undetectable		 2rkfB-3h2sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 8 LEU A 200
ASP A  64
THR A  98
HIS A  88
 None
 1.11A 3asnC-3h2sA:
undetectable
3asnN-3h2sA:
undetectable
3asnP-3h2sA:
undetectable		 3asnC-3h2sA:
22.46
3asnN-3h2sA:
17.81
3asnP-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 8 LEU A 200
ASP A  64
THR A  98
HIS A  88
 None
 1.11A 3asoC-3h2sA:
undetectable
3asoN-3h2sA:
undetectable
3asoP-3h2sA:
undetectable		 3asoC-3h2sA:
22.46
3asoN-3h2sA:
17.81
3asoP-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 8 ASP A  33
VAL A  31
GLY A  42
VAL A   5
 None
 0.63A 3nu9A-3h2sA:
undetectable		 3nu9A-3h2sA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 5 GLY A  79
ASP A 133
GLN A 143
MET A 147
 None
 1.22A 3qx3A-3h2sA:
undetectable		 3qx3A-3h2sA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 5 GLY A  79
ASP A 133
GLN A 143
MET A 147
 None
 1.26A 3qx3B-3h2sA:
undetectable		 3qx3B-3h2sA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.03A 4coxC-3h2sA:
undetectable		 4coxC-3h2sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 PHE A 102
ALA A 100
LEU A  92
LEU A  93
ARG A 207
 None
 1.11A 4dm8B-3h2sA:
undetectable		 4dm8B-3h2sA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		3 / 3 ASP A 175
TRP A 153
SER A 157
 None
 1.06A 4lrhF-3h2sA:
undetectable		 4lrhF-3h2sA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 ILE A   3
ALA A  15
ILE A 103
VAL A  67
VAL A   5
 None
None
NDP  A 301 (-3.7A)
None
None
 0.85A 4nkxA-3h2sA:
undetectable		 4nkxA-3h2sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 ILE A   3
ALA A  15
ILE A 103
VAL A  67
VAL A   5
 None
None
NDP  A 301 (-3.7A)
None
None
 0.87A 4nkxB-3h2sA:
undetectable		 4nkxB-3h2sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.03A 4otyA-3h2sA:
undetectable		 4otyA-3h2sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.05A 4otyB-3h2sA:
undetectable		 4otyB-3h2sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.05A 4rrwD-3h2sA:
undetectable		 4rrwD-3h2sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.05A 4rrzD-3h2sA:
undetectable		 4rrzD-3h2sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 THR A  87
LEU A  89
ALA A  86
LEU A  70
GLY A  79
 None
None
None
NDP  A 301 (-4.4A)
None
 1.03A 4xi3C-3h2sA:
undetectable		 4xi3C-3h2sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 8 ASP A  64
THR A  98
HIS A  88
LEU A 200
 None
 1.02A 5b1bA-3h2sA:
undetectable
5b1bC-3h2sA:
undetectable
5b1bP-3h2sA:
undetectable		 5b1bA-3h2sA:
17.81
5b1bC-3h2sA:
22.46
5b1bP-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 THR A  87
LEU A  89
ALA A  86
LEU A  70
GLY A  79
 None
None
None
NDP  A 301 (-4.4A)
None
 1.04A 5gs4A-3h2sA:
undetectable		 5gs4A-3h2sA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 6 HIS A  88
GLU A  57
ALA A   4
LEU A  28
 None
 0.89A 5igiA-3h2sA:
undetectable		 5igiA-3h2sA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.08A 5ikqA-3h2sA:
undetectable		 5ikqA-3h2sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 12 VAL A  27
LEU A  28
VAL A  31
GLY A   7
ALA A   8
 None
None
None
NDP  A 301 (-3.2A)
None
 1.09A 5ikqB-3h2sA:
undetectable		 5ikqB-3h2sA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		5 / 10 LEU A   6
GLY A   7
GLY A  13
VAL A  27
LEU A  28
 None
NDP  A 301 (-3.2A)
None
None
None
 1.08A 5o96E-3h2sA:
2.8
5o96F-3h2sA:
undetectable		 5o96E-3h2sA:
23.44
5o96F-3h2sA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 8 ASP A  64
THR A  98
HIS A  88
LEU A 200
 None
 1.03A 5wauA-3h2sA:
undetectable
5wauC-3h2sA:
undetectable
5wauc-3h2sA:
undetectable		 5wauA-3h2sA:
17.81
5wauC-3h2sA:
22.46
5wauc-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 7 LEU A 200
ASP A  64
THR A  98
HIS A  88
 None
 1.06A 5wauC-3h2sA:
undetectable
5waua-3h2sA:
undetectable
5wauc-3h2sA:
undetectable		 5wauC-3h2sA:
22.46
5waua-3h2sA:
17.81
5wauc-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 7 ASP A  64
THR A  98
HIS A  88
LEU A 200
 None
 1.10A 5x1bA-3h2sA:
undetectable
5x1bC-3h2sA:
undetectable
5x1bP-3h2sA:
undetectable		 5x1bA-3h2sA:
17.81
5x1bC-3h2sA:
22.46
5x1bP-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 8 LEU A 200
ASP A  64
THR A  98
HIS A  88
 None
 1.11A 6nknC-3h2sA:
undetectable
6nknN-3h2sA:
undetectable
6nknP-3h2sA:
undetectable		 6nknC-3h2sA:
22.46
6nknN-3h2sA:
17.81
6nknP-3h2sA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h2s PUTATIVE NADH-FLAVIN
REDUCTASE
(Lactobacillus
paracasei) 		4 / 7 ASP A  64
THR A  98
HIS A  88
LEU A 200
 None
 1.08A 6nmfA-3h2sA:
undetectable
6nmfC-3h2sA:
undetectable
6nmfP-3h2sA:
undetectable		 6nmfA-3h2sA:
17.81
6nmfC-3h2sA:
22.46
6nmfP-3h2sA:
22.46