SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 3h2u RAVER-1
(Homo
sapiens) 		4 / 5 VAL B  75
ASN B  72
VAL B  98
ILE B  63
 None
 1.06A 1z2bC-3h2uB:
undetectable		 1z2bC-3h2uB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3h2u RAVER-1
(Homo
sapiens) 		5 / 12 VAL B 136
ALA B 189
ALA B 178
TYR B 180
ARG B 160
 None
 1.28A 2avdA-3h2uB:
undetectable		 2avdA-3h2uB:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3h2u RAVER-1
(Homo
sapiens) 		3 / 3 VAL B  70
ASP B  69
GLU B  74
 None
 0.71A 2qeuA-3h2uB:
undetectable		 2qeuA-3h2uB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3h2u RAVER-1
(Homo
sapiens) 		3 / 3 VAL B  70
ASP B  69
GLU B  74
 None
 0.71A 2qeuC-3h2uB:
undetectable		 2qeuC-3h2uB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3h2u RAVER-1
(Homo
sapiens) 		3 / 3 ARG B 227
ASP B 283
ASP B 226
 None
 0.90A 3jayA-3h2uB:
undetectable		 3jayA-3h2uB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 3h2u RAVER-1
(Homo
sapiens) 		3 / 3 ARG B 227
ASP B 283
ASP B 226
 None
 0.87A 3jb2A-3h2uB:
undetectable		 3jb2A-3h2uB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3h2u RAVER-1
(Homo
sapiens) 		4 / 6 ARG B 221
ASP B 209
GLU B 179
LEU B 217
 None
 1.41A 4ax8A-3h2uB:
undetectable		 4ax8A-3h2uB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3h2u RAVER-1
(Homo
sapiens) 		5 / 12 GLN B 147
LEU B 139
PRO B 140
LEU B 163
TYR B 180
 None
 1.06A 4m2xC-3h2uB:
undetectable		 4m2xC-3h2uB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3h2u RAVER-1
(Homo
sapiens) 		4 / 8 SER B 243
LEU B 267
LEU B 223
VAL B 225
 None
 0.80A 4oj4A-3h2uB:
undetectable		 4oj4A-3h2uB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3h2u RAVER-1
(Homo
sapiens) 		3 / 3 VAL B 235
ALA B 265
PHE B 232
 None
 0.88A 4olbA-3h2uB:
3.6		 4olbA-3h2uB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3h2u RAVER-1
(Homo
sapiens) 		5 / 7 GLU B 150
LEU B 151
LEU B 139
ARG B 201
LEU B 203
 None
 1.30A 4wg0B-3h2uB:
undetectable
4wg0C-3h2uB:
undetectable		 4wg0B-3h2uB:
6.03
4wg0C-3h2uB:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3h2u RAVER-1
(Homo
sapiens) 		3 / 3 VAL B 235
ALA B 265
PHE B 232
 None
 0.87A 4z4iA-3h2uB:
3.8		 4z4iA-3h2uB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3h2u RAVER-1
(Homo
sapiens) 		3 / 3 VAL B 235
ALA B 265
PHE B 232
 None
 0.86A 5js1A-3h2uB:
4.2		 5js1A-3h2uB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3h2u RAVER-1
(Homo
sapiens) 		5 / 10 LEU B 193
GLY B 195
LEU B 151
LEU B 198
THR B 202
 None
 1.05A 5o96G-3h2uB:
undetectable
5o96H-3h2uB:
undetectable		 5o96G-3h2uB:
21.86
5o96H-3h2uB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3h2u RAVER-1
(Homo
sapiens) 		5 / 12 PHE B 162
GLU B  52
HIS B 206
THR B 130
GLY B 211
 None
 1.42A 5xioA-3h2uB:
undetectable		 5xioA-3h2uB:
18.20