SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		4 / 5 GLN A 187
ARG A 172
ALA A 144
ARG A 141
 None
None
None
PO4  A 901 ( 4.9A)
 1.46A 2qhfA-3h2xA:
undetectable		 2qhfA-3h2xA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 ASN A  58
ASN A  86
ARG A 269
 None
 0.74A 2rlcA-3h2xA:
undetectable		 2rlcA-3h2xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 SER A 201
GLU A 280
ASP A 197
 None
 0.76A 2zthA-3h2xA:
undetectable		 2zthA-3h2xA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 SER A 201
GLU A 280
ASP A 197
 None
 0.68A 3bwmA-3h2xA:
undetectable		 3bwmA-3h2xA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 SER A 201
GLU A 280
ASP A 197
 None
 0.74A 3bwyA-3h2xA:
undetectable		 3bwyA-3h2xA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 TYR A 242
GLY A  92
ASP A 219
 None
 0.64A 3ou6C-3h2xA:
undetectable		 3ou6C-3h2xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		5 / 11 ILE A 100
ILE A 125
ILE A  85
VAL A 122
PRO A 222
 None
 0.97A 3tmzA-3h2xA:
undetectable		 3tmzA-3h2xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		4 / 8 MET A 127
ARG A 172
GLU A 145
GLU A 131
 None
None
None
PO4  A 903 ( 3.0A)
 1.13A 4bqfB-3h2xA:
undetectable		 4bqfB-3h2xA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 VAL A  93
GLY A  95
LYS A  91
 None
 0.72A 4k50A-3h2xA:
undetectable		 4k50A-3h2xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 VAL A  93
GLY A  95
LYS A  91
 None
 0.70A 4k50I-3h2xA:
0.7		 4k50I-3h2xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		5 / 12 PHE A 256
GLY A 250
GLN A   3
VAL A  93
VAL A 286
 None
 0.95A 4wnwA-3h2xA:
undetectable		 4wnwA-3h2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		5 / 12 PHE A 256
GLY A 250
GLN A   3
VAL A  93
VAL A 286
 None
 1.02A 4wnwB-3h2xA:
undetectable		 4wnwB-3h2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		3 / 3 SER A 201
GLU A 280
ASP A 197
 None
 0.74A 4xudA-3h2xA:
undetectable		 4xudA-3h2xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		5 / 12 ILE A 252
VAL A 286
ALA A  98
GLY A  95
TYR A  94
 None
 0.92A 5uxdB-3h2xA:
undetectable		 5uxdB-3h2xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens) 		5 / 9 ILE A 205
GLU A 277
VAL A 236
ILE A 237
MET A 130
 None
None
None
None
PO4  A 901 (-4.0A)
 1.18A 6hloA-3h2xA:
undetectable		 6hloA-3h2xA:
20.73