SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.02A 1ddrA-3h39A:
undetectable		 1ddrA-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.06A 1ddsA-3h39A:
undetectable		 1ddsA-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.03A 1dyiA-3h39A:
undetectable		 1dyiA-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.06A 1dyiB-3h39A:
undetectable		 1dyiB-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A  51
ARG A 187
PHE A 188
PHE A 190
 None
ATP  A 501 (-3.3A)
None
None
 1.12A 1e72M-3h39A:
undetectable		 1e72M-3h39A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 10 GLU A 317
ALA A 320
LYS A 259
ALA A 353
LEU A 355
 None
 1.33A 1ie4A-3h39A:
undetectable
1ie4C-3h39A:
undetectable		 1ie4A-3h39A:
16.40
1ie4C-3h39A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.13A 1rg7A-3h39A:
undetectable		 1rg7A-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.04A 1tdrA-3h39A:
undetectable		 1tdrA-3h39A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A  92
GLY A  94
LEU A  90
SER A  89
 None
 0.78A 3aiaA-3h39A:
undetectable		 3aiaA-3h39A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 8 GLU A 185
PHE A 171
ARG A 236
PHE A 240
 None
 0.85A 3mjrD-3h39A:
undetectable		 3mjrD-3h39A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A 223
ARG A 180
ASP A  46
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.3A)
None
 1.37A 3o7wA-3h39A:
undetectable		 3o7wA-3h39A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 280
LEU A 225
LEU A 288
ASP A 278
PHE A 247
 None
 1.09A 3tbgA-3h39A:
undetectable		 3tbgA-3h39A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 7 LYS A  81
LEU A  79
ALA A  88
LEU A  90
 None
 0.83A 4d7bA-3h39A:
undetectable		 4d7bA-3h39A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.06A 4dfrA-3h39A:
undetectable		 4dfrA-3h39A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.13A 4ej1B-3h39A:
undetectable		 4ej1B-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 9 GLU A  32
GLY A  30
VAL A  37
PRO A  36
GLY A  62
 None
 1.44A 4fimA-3h39A:
undetectable		 4fimA-3h39A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 8 LYS A  81
LEU A  79
ALA A  88
LEU A  90
 None
 0.78A 4iizB-3h39A:
undetectable		 4iizB-3h39A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.09A 4qlgB-3h39A:
undetectable		 4qlgB-3h39A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 280
LEU A 225
LEU A 288
ASP A 278
PHE A 247
 None
 1.00A 4wnwB-3h39A:
undetectable		 4wnwB-3h39A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.04A 4x5gA-3h39A:
undetectable		 4x5gA-3h39A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.00A 4x5hA-3h39A:
undetectable		 4x5hA-3h39A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 4 GLY A  41
VAL A  39
PHE A   4
ILE A 149
 ATP  A 501 (-3.3A)
None
None
None
 1.15A 4xv2B-3h39A:
undetectable		 4xv2B-3h39A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 7 LEU A 179
LEU A 221
THR A 212
THR A 176
 None
None
None
ATP  A 501 (-4.6A)
 0.88A 4z90A-3h39A:
undetectable
4z90B-3h39A:
undetectable
4z90C-3h39A:
undetectable
4z90D-3h39A:
undetectable
4z90E-3h39A:
undetectable		 4z90A-3h39A:
21.90
4z90B-3h39A:
21.90
4z90C-3h39A:
21.90
4z90D-3h39A:
21.90
4z90E-3h39A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.09A 5e8qB-3h39A:
undetectable		 5e8qB-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.08A 5eajB-3h39A:
undetectable		 5eajB-3h39A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 9 LEU A  26
ILE A  56
GLU A  66
PHE A  67
VAL A  33
 None
 1.39A 5igzA-3h39A:
undetectable		 5igzA-3h39A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		3 / 3 ARG A   5
ILE A 149
PHE A   4
 None
 0.73A 5kirA-3h39A:
undetectable		 5kirA-3h39A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 5 ALA A 422
VAL A 420
LYS A 400
ILE A 416
 None
 0.95A 5of1A-3h39A:
undetectable		 5of1A-3h39A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 320
LEU A 355
THR A 347
ILE A 348
LEU A 367
 None
 1.09A 5ujxB-3h39A:
undetectable		 5ujxB-3h39A:
15.19