SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 LEU A  40
ILE A 150
LEU A 120
LEU A  52
LEU A  49
 None
 1.20A 1errB-3h3bA:
undetectable		 1errB-3h3bA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		6 / 12 TYR C  42
GLN C  95
PHE C 104
ASN C 169
VAL C 171
TRP C 244
 None
 0.70A 1h8sA-3h3bC:
31.8		 1h8sA-3h3bC:
65.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		6 / 12 TYR C  42
GLN C  95
TYR C 100
ASN C 169
VAL C 171
TRP C 244
 None
 0.71A 1h8sA-3h3bC:
31.8		 1h8sA-3h3bC:
65.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		5 / 11 LEU C 110
GLU C  17
VAL C  13
LEU C  53
LEU C  79
 None
 1.35A 1mrqA-3h3bC:
undetectable		 1mrqA-3h3bC:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		5 / 7 PRO C 179
TYR C 229
TYR C  42
PRO C  50
TYR C  93
 None
 0.97A 2oldA-3h3bC:
16.9
2oldB-3h3bC:
16.8		 2oldA-3h3bC:
33.21
2oldB-3h3bC:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		5 / 7 TYR C  42
PRO C  50
TYR C  93
PRO C 179
TYR C 229
 None
 0.92A 2oldA-3h3bC:
16.9
2oldB-3h3bC:
16.8		 2oldA-3h3bC:
33.21
2oldB-3h3bC:
33.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 LEU A 118
VAL A  80
ILE A  55
TYR A  28
 None
 0.92A 2weyB-3h3bA:
undetectable		 2weyB-3h3bA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 TYR A  28
ILE A  64
GLY A   6
VAL A  80
LEU A  52
 None
 1.20A 3elzB-3h3bA:
undetectable		 3elzB-3h3bA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 TYR A  28
ILE A  64
GLY A   6
VAL A  80
LEU A  52
 None
 1.19A 3elzC-3h3bA:
undetectable		 3elzC-3h3bA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 10 TYR A  28
ILE A  64
GLY A   6
VAL A  80
LEU A  52
 None
 1.24A 3em0A-3h3bA:
undetectable		 3em0A-3h3bA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 TYR A  28
VAL A   3
ASN A  37
GLY A  36
 None
 1.15A 3kmoB-3h3bA:
undetectable		 3kmoB-3h3bA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens;
Mus
musculus) 		4 / 7 VAL A 131
ILE A 150
THR A 144
TYR C 236
 None
 1.07A 3tneB-3h3bA:
undetectable		 3tneB-3h3bA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 9 ASN A  37
GLY A  36
GLY A  60
GLY A   6
ASP A   8
 None
 0.96A 3ztvA-3h3bA:
undetectable		 3ztvA-3h3bA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		4 / 8 ILE C 154
PRO C  50
VAL C 231
TRP C 244
 None
 1.27A 4f4dB-3h3bC:
undetectable		 4f4dB-3h3bC:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 VAL A 131
TRP A 147
ILE A 150
LEU A 120
 None
 0.92A 4jq1B-3h3bA:
undetectable		 4jq1B-3h3bA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		4 / 5 VAL C 136
TYR C 161
ARG C 232
TYR C 243
 None
 0.34A 4m7kH-3h3bC:
15.1		 4m7kH-3h3bC:
63.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 ARG A  81
GLY A  60
THR A  83
VAL A  34
 None
 0.97A 4qwpB-3h3bA:
undetectable		 4qwpB-3h3bA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 VAL A 131
TRP A 147
ILE A 150
LEU A  74
 None
 1.10A 4xo7B-3h3bA:
undetectable		 4xo7B-3h3bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		5 / 12 VAL A 131
TRP A 147
LEU A 118
LEU A 115
VAL A  94
 None
 1.11A 5im2A-3h3bA:
undetectable		 5im2A-3h3bA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3h3b ANTI-ERBB2 ANTIBODY
CHA21
(Mus
musculus) 		4 / 6 ILE C 185
GLY C 234
ASN C 235
ILE C 168
 None
 0.93A 5j4nB-3h3bC:
undetectable		 5j4nB-3h3bC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 HIS A 152
ARG A  78
GLU A 125
GLU A  57
 None
 0.94A 6mn4A-3h3bA:
undetectable		 6mn4A-3h3bA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 8 HIS A 152
ARG A  78
GLU A 125
GLU A  57
 None
 1.11A 6mn4B-3h3bA:
undetectable		 6mn4B-3h3bA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens) 		4 / 7 HIS A 152
ARG A  78
GLU A 125
GLU A  57
 None
 0.83A 6mn4F-3h3bA:
undetectable		 6mn4F-3h3bA:
22.64