SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		3 / 3 TRP A 134
ALA A 259
VAL A 144
 None
 0.92A 1c4dA-3h3jA:
undetectable
1c4dB-3h3jA:
undetectable		 1c4dA-3h3jA:
3.42
1c4dB-3h3jA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 9 ILE A  80
PHE A 119
TYR A  69
ILE A 106
ALA A  82
 None
None
None
NAD  A 500 ( 4.9A)
NAD  A 500 (-3.5A)
 1.28A 1mrgA-3h3jA:
undetectable		 1mrgA-3h3jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 4 ILE A 243
LEU A 240
VAL A 236
ALA A 231
 None
None
NAD  A 500 (-4.2A)
NAD  A 500 ( 4.5A)
 0.82A 1mz9A-3h3jA:
undetectable		 1mz9A-3h3jA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 5 ILE A 243
LEU A 240
VAL A 236
ALA A 231
 None
None
NAD  A 500 (-4.2A)
NAD  A 500 ( 4.5A)
 0.81A 1mz9C-3h3jA:
undetectable		 1mz9C-3h3jA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 12 ILE A  12
GLY A  13
GLY A  15
LEU A  39
ALA A  82
 None
NAD  A 500 ( 4.2A)
NAD  A 500 (-3.3A)
NAD  A 500 (-4.2A)
NAD  A 500 (-3.5A)
 0.88A 2fk8A-3h3jA:
5.7		 2fk8A-3h3jA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 7 ARG A 204
ILE A 214
PHE A 164
GLU A 162
 None
 1.49A 2nsiA-3h3jA:
undetectable
2nsiB-3h3jA:
undetectable		 2nsiA-3h3jA:
20.09
2nsiB-3h3jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 7 GLY A  18
GLY A  15
VAL A  79
LEU A 240
 None
NAD  A 500 (-3.3A)
None
None
 0.81A 2oa1B-3h3jA:
3.4		 2oa1B-3h3jA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 11 VAL A 186
GLN A 174
ILE A 272
PHE A 299
LEU A 261
 None
 0.79A 2q6hA-3h3jA:
undetectable		 2q6hA-3h3jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 12 VAL A 186
GLN A 174
ILE A 272
PHE A 299
LEU A 261
 None
 0.82A 2qb4A-3h3jA:
undetectable		 2qb4A-3h3jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 11 VAL A 186
GLN A 174
ILE A 272
PHE A 299
LEU A 261
 None
 0.84A 2qeiA-3h3jA:
undetectable		 2qeiA-3h3jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 7 LEU A 129
ALA A  84
GLY A  83
PHE A 103
PHE A 136
 None
None
NAD  A 500 (-4.1A)
None
None
 1.44A 2wq5A-3h3jA:
undetectable		 2wq5A-3h3jA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 12 ILE A 150
LEU A 255
ILE A 278
ALA A 246
LEU A 120
 None
 1.15A 3a50A-3h3jA:
undetectable		 3a50A-3h3jA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 4 ASP A  47
GLY A  46
LYS A  43
GLU A  42
 None
 1.29A 3hznD-3h3jA:
undetectable		 3hznD-3h3jA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 10 LEU A 184
SER A 302
ILE A 176
SER A 258
GLY A 273
 None
 1.27A 3ijxB-3h3jA:
undetectable
3ijxD-3h3jA:
undetectable		 3ijxB-3h3jA:
22.35
3ijxD-3h3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 10 ILE A 176
SER A 258
GLY A 273
LEU A 184
SER A 302
 None
 1.36A 3ik6B-3h3jA:
undetectable
3ik6E-3h3jA:
undetectable		 3ik6B-3h3jA:
22.35
3ik6E-3h3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 10 LEU A 184
SER A 302
ILE A 176
SER A 258
GLY A 273
 None
 1.21A 3ik6B-3h3jA:
undetectable
3ik6E-3h3jA:
undetectable		 3ik6B-3h3jA:
22.35
3ik6E-3h3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 10 LEU A 184
SER A 302
ILE A 176
SER A 258
GLY A 273
 None
 1.21A 3iluB-3h3jA:
undetectable
3iluE-3h3jA:
undetectable		 3iluB-3h3jA:
22.35
3iluE-3h3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 11 ILE A 176
SER A 258
GLY A 273
LEU A 184
SER A 302
 None
 1.24A 3iluB-3h3jA:
undetectable
3iluE-3h3jA:
undetectable		 3iluB-3h3jA:
22.35
3iluE-3h3jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		3 / 3 ARG A  92
ARG A 155
ASP A 220
 PYR  A 501 (-3.9A)
PYR  A 501 (-2.9A)
None
 0.96A 3wipG-3h3jA:
undetectable
3wipH-3h3jA:
undetectable		 3wipG-3h3jA:
22.39
3wipH-3h3jA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 6 VAL A   9
VAL A  31
ILE A  30
LEU A 240
 None
 0.93A 4l1wB-3h3jA:
undetectable		 4l1wB-3h3jA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 11 ASN A   7
VAL A  31
ILE A 243
TYR A  21
ALA A 241
 None
 1.44A 4m83A-3h3jA:
undetectable		 4m83A-3h3jA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 11 ASN A   7
VAL A  31
ILE A 243
TYR A  21
ALA A 241
 None
 1.43A 4m83B-3h3jA:
undetectable		 4m83B-3h3jA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		6 / 9 ASP A  38
TYR A  69
ALA A  82
ARG A  85
ILE A 102
ILE A 106
 NAD  A 500 (-2.5A)
None
NAD  A 500 (-3.5A)
NAD  A 500 (-3.6A)
NAD  A 500 ( 4.5A)
NAD  A 500 ( 4.9A)
 1.28A 4oknB-3h3jA:
41.1		 4oknB-3h3jA:
38.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 5 GLU A 268
GLU A 264
TYR A 265
GLU A 267
 None
 1.30A 4r87E-3h3jA:
undetectable		 4r87E-3h3jA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 4 ASN A   7
ILE A  36
TYR A  21
PHE A 119
 None
 1.33A 5igvA-3h3jA:
undetectable		 5igvA-3h3jA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 6 LEU A 151
ILE A 214
THR A 218
TRP A 187
 NAD  A 500 ( 4.1A)
None
None
None
 1.38A 5ljeA-3h3jA:
undetectable		 5ljeA-3h3jA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		5 / 12 PHE A 115
ALA A 122
SER A 147
VAL A  79
ILE A  80
 None
NAD  A 500 (-4.2A)
NAD  A 500 (-3.3A)
None
None
 1.38A 5mlmA-3h3jA:
8.4		 5mlmA-3h3jA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 4 HIS A 179
LEU A 120
TYR A  21
GLY A 239
 PYR  A 501 ( 3.9A)
None
None
None
 1.24A 6n91A-3h3jA:
undetectable		 6n91A-3h3jA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 3h3j L-LACTATE
DEHYDROGENASE 1
(Staphylococcus
aureus) 		4 / 4 HIS A 179
LEU A 120
TYR A  21
GLY A 239
 PYR  A 501 ( 3.9A)
None
None
None
 1.24A 6n91B-3h3jA:
undetectable		 6n91B-3h3jA:
15.34