SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 VAL A 113
ILE A  16
ARG A  11
LEU A  28
ILE A 109
 None
 0.87A 1d1gB-3h3zA:
undetectable		 1d1gB-3h3zA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 LEU A  15
ALA A  10
LEU A  28
LEU A  27
HIS A  53
 None
 1.45A 1pcgB-3h3zA:
undetectable		 1pcgB-3h3zA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 LEU A  15
ALA A  10
LEU A  28
LEU A  27
HIS A  53
 None
 1.40A 1qktA-3h3zA:
undetectable		 1qktA-3h3zA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 8 TYR A  94
TYR A  36
HIS A  53
HIS A 108
 None
 1.25A 2bteD-3h3zA:
undetectable		 2bteD-3h3zA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 VAL A  24
LEU A  27
ILE A 109
ILE A  52
ALA A  88
 None
 1.04A 2gj5A-3h3zA:
undetectable		 2gj5A-3h3zA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 8 TYR A  94
TYR A  36
HIS A  53
HIS A 108
 None
 1.24A 2v0gA-3h3zA:
undetectable		 2v0gA-3h3zA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 VAL A 113
ILE A 128
ILE A  16
LEU A  28
ILE A 109
 None
 1.00A 3clbA-3h3zA:
undetectable		 3clbA-3h3zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 VAL A 113
ILE A 128
ILE A  16
LEU A  28
ILE A 109
 None
 1.02A 3clbC-3h3zA:
undetectable		 3clbC-3h3zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		6 / 12 ALA A 130
VAL A  24
ILE A  16
LEU A  15
THR A 131
PHE A 133
 None
 1.50A 3cs9C-3h3zA:
undetectable		 3cs9C-3h3zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 VAL A 113
ILE A 128
ILE A  16
LEU A  28
ILE A 109
 None
 0.99A 3hbbA-3h3zA:
undetectable		 3hbbA-3h3zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 VAL A 113
ILE A 128
ILE A  16
LEU A  28
ILE A 109
 None
 1.04A 3hbbC-3h3zA:
undetectable		 3hbbC-3h3zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		3 / 3 LEU A 174
PRO A 175
ARG A 154
 None
 0.68A 4klrB-3h3zA:
undetectable		 4klrB-3h3zA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 VAL A  87
ILE A  52
SER A 111
PHE A  83
LEU A  15
 None
 1.21A 4lhmA-3h3zA:
undetectable		 4lhmA-3h3zA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 LEU A  15
ALA A  10
LEU A  28
LEU A  27
HIS A  53
 None
 1.43A 5dxeB-3h3zA:
undetectable		 5dxeB-3h3zA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 LEU A  15
ALA A  10
LEU A  28
LEU A  27
HIS A  53
 None
 1.46A 5hyrA-3h3zA:
undetectable		 5hyrA-3h3zA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 11 ILE A 181
LEU A 192
ALA A 195
VAL A  76
LEU A 162
 None
 1.13A 5ji0A-3h3zA:
undetectable		 5ji0A-3h3zA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3h3z CYCLIC
NUCLEOTIDE-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 LEU A  62
VAL A 101
LEU A 162
LEU A 174
THR A 173
 None
 1.18A 6b52A-3h3zA:
undetectable		 6b52A-3h3zA:
19.92