SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE
(Trypanosoma
brucei) 		5 / 10 GLU A 193
ALA A 181
GLU A 177
LEU A 163
MET A 151
 None
 1.50A 1a29A-3h4cA:
undetectable		 1a29A-3h4cA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE
(Trypanosoma
brucei) 		4 / 8 GLU A 156
ARG A 120
LEU A 196
GLU A 193
 None
 0.93A 1cmaA-3h4cA:
undetectable
1cmaB-3h4cA:
undetectable		 1cmaA-3h4cA:
16.03
1cmaB-3h4cA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE
(Trypanosoma
brucei) 		4 / 6 ASP A 202
LEU A 205
VAL A 206
ILE A 209
 None
 0.55A 1s9qA-3h4cA:
undetectable		 1s9qA-3h4cA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE
(Trypanosoma
brucei) 		5 / 12 ARG A 133
ILE A 183
ILE A 152
GLY A 121
ILE A 122
 None
 0.74A 2o4nA-3h4cA:
undetectable		 2o4nA-3h4cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE
(Trypanosoma
brucei) 		4 / 8 THR A 257
GLN A 256
TYR A 219
CYH A 223
 None
 1.23A 2xz5A-3h4cA:
undetectable
2xz5C-3h4cA:
undetectable		 2xz5A-3h4cA:
18.53
2xz5C-3h4cA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE
(Trypanosoma
brucei) 		5 / 12 SER A 192
GLU A 155
GLU A 156
VAL A 145
ILE A 183
 None
 1.37A 3jayA-3h4cA:
undetectable		 3jayA-3h4cA:
14.50