SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 GLU A  40
LYS A  37
VAL A  38
None
0.94A 1l2iA-3h4hA:
undetectable
1l2iA-3h4hA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 TRP A 144
HIS A  95
MET A  62
None
CU  A1501 (-3.2A)
CU  A1501 ( 4.3A)
1.49A 1l5qB-3h4hA:
undetectable
1l5qB-3h4hA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.30A 1oe1A-3h4hA:
53.9
1oe1A-3h4hA:
65.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 ASP A  98
HIS A 100
HIS A 135
CU  A1502 ( 4.0A)
CU  A1502 (-3.3A)
CU  A1502 (-3.2A)
0.09A 1oe1A-3h4hA:
53.9
1oe1A-3h4hA:
65.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 5 HIS A  95
CYH A 136
PRO A 138
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
None
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.28A 1oe2A-3h4hA:
53.8
1oe2A-3h4hA:
65.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.30A 1oe3A-3h4hA:
53.2
1oe3A-3h4hA:
65.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 ASP A  98
HIS A 100
HIS A 135
CU  A1502 ( 4.0A)
CU  A1502 (-3.3A)
CU  A1502 (-3.2A)
0.10A 1oe3A-3h4hA:
53.2
1oe3A-3h4hA:
65.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 10 SER A 246
VAL A 133
ALA A 248
HIS A 135
VAL A 146
None
None
None
CU  A1502 (-3.2A)
None
1.46A 1td2A-3h4hA:
undetectable
1td2A-3h4hA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.66A 2fqdA-3h4hA:
20.4
2fqdA-3h4hA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.62A 2fqeA-3h4hA:
20.3
2fqeA-3h4hA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.61A 2fqfA-3h4hA:
20.4
2fqfA-3h4hA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.62A 2fqgA-3h4hA:
20.4
2fqgA-3h4hA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 12 GLY A 289
GLY A 286
ALA A 248
VAL A 264
LEU A 242
None
1.02A 2nyuA-3h4hA:
undetectable
2nyuA-3h4hA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.34A 2xxgA-3h4hA:
53.6
2xxgA-3h4hA:
65.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 ASP A  98
HIS A 100
HIS A 135
CU  A1502 ( 4.0A)
CU  A1502 (-3.3A)
CU  A1502 (-3.2A)
0.09A 2xxgA-3h4hA:
53.6
2xxgA-3h4hA:
65.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 5 HIS A  95
CYH A 136
PRO A 138
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
None
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.30A 2xxgC-3h4hA:
53.5
2xxgC-3h4hA:
65.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 ASP A  98
HIS A 100
HIS A 135
CU  A1502 ( 4.0A)
CU  A1502 (-3.3A)
CU  A1502 (-3.2A)
0.07A 2xxgC-3h4hA:
53.5
2xxgC-3h4hA:
65.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 12 ILE A  86
VAL A  44
ILE A  45
ILE A 114
PRO A  88
None
1.21A 2yzqA-3h4hA:
undetectable
2yzqA-3h4hA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 8 PHE A 124
PHE A 132
ASP A  98
GLY A 107
None
None
CU  A1502 ( 4.0A)
None
0.79A 3c0zB-3h4hA:
undetectable
3c0zB-3h4hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 GLU A 180
HIS A 245
THR A 252
None
0.82A 3hkuA-3h4hA:
undetectable
3hkuA-3h4hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 5 GLU A 239
GLY A 238
TYR A 293
GLN A 296
None
1.43A 3w9tB-3h4hA:
undetectable
3w9tB-3h4hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 5 GLU A 239
GLY A 238
TYR A 293
GLN A 296
None
1.44A 3w9tD-3h4hA:
undetectable
3w9tD-3h4hA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 7 PRO A 284
ILE A 283
GLY A 268
VAL A 131
None
1.00A 4a3uB-3h4hA:
undetectable
4a3uB-3h4hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 4 HIS A  95
CYH A 136
HIS A 145
MET A 150
CU  A1501 (-3.2A)
CU  A1501 (-2.2A)
CU  A1501 (-3.0A)
CU  A1501 (-2.4A)
0.61A 4ef3A-3h4hA:
20.2
4ef3A-3h4hA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 12 GLY A 285
GLY A 286
ILE A 283
VAL A 218
GLN A 181
None
1.17A 4fglA-3h4hA:
undetectable
4fglB-3h4hA:
undetectable
4fglA-3h4hA:
21.41
4fglB-3h4hA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
4 / 5 HIS A  60
THR A  92
GLU A  47
HIS A 145
None
None
None
CU  A1501 (-3.0A)
1.14A 4hvcB-3h4hA:
undetectable
4hvcB-3h4hA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 11 VAL A 218
GLN A 181
GLY A 285
GLY A 286
ILE A 283
None
1.14A 4zvmA-3h4hA:
undetectable
4zvmB-3h4hA:
undetectable
4zvmA-3h4hA:
21.17
4zvmB-3h4hA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
5 / 9 TYR A 134
LEU A  81
VAL A  39
LEU A 157
HIS A  28
None
1.49A 5mxbA-3h4hA:
0.0
5mxbA-3h4hA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 THR A  92
GLU A  47
HIS A  60
None
0.91A 5xioA-3h4hA:
undetectable
5xioA-3h4hA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 THR A  92
GLU A  47
HIS A  60
None
0.89A 5xiqB-3h4hA:
undetectable
5xiqB-3h4hA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 THR A  92
GLU A  47
HIS A  60
None
0.91A 5xiqD-3h4hA:
undetectable
5xiqD-3h4hA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))
3h4h COPPER-CONTAINING
NITRITE REDUCTASE

(Alcaligenes
faecalis)
3 / 3 THR A  92
GLU A  47
HIS A 145
None
None
CU  A1501 (-3.0A)
0.93A 5xiqD-3h4hA:
undetectable
5xiqD-3h4hA:
19.80