SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
5 / 12 SER B 216
LEU B 162
VAL B 170
VAL B 220
ALA B 143
None
1.25A 1q23H-3h4jB:
undetectable
1q23I-3h4jB:
undetectable
1q23H-3h4jB:
18.86
1q23I-3h4jB:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
5 / 12 ALA B 326
PHE B 318
LEU B 312
SER B  84
LEU B  88
None
1.08A 3k2hB-3h4jB:
undetectable
3k2hB-3h4jB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
5 / 9 ILE B  94
ILE B  95
MET B 109
TYR B 113
ILE B 172
None
0.70A 3zosA-3h4jB:
9.1
3zosA-3h4jB:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
6 / 11 LEU B  40
GLY B  41
GLY B  43
VAL B  48
ALA B  61
TYR B 113
None
0.69A 4ckiA-3h4jB:
15.6
4ckiA-3h4jB:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
4 / 6 ASN B 167
ARG B 135
TYR B 292
LEU B 352
None
1.46A 4f8yA-3h4jB:
undetectable
4f8yB-3h4jB:
undetectable
4f8yA-3h4jB:
22.55
4f8yB-3h4jB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
5 / 10 LYS B  96
CYH B 147
LEU B  88
HIS B  91
TYR B 146
None
0.98A 4ij8A-3h4jB:
0.0
4ij8B-3h4jB:
0.0
4ij8A-3h4jB:
20.71
4ij8B-3h4jB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
4 / 5 GLY B 133
LEU B 164
ILE B 122
LEU B 293
None
0.78A 4o8fA-3h4jB:
undetectable
4o8fA-3h4jB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
4 / 8 ILE B  95
TYR B 113
LEU B 163
ILE B 172
None
0.58A 4v04A-3h4jB:
16.0
4v04A-3h4jB:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
4 / 8 LYS B  63
ILE B  95
TYR B 113
ILE B 172
None
0.49A 4v04A-3h4jB:
16.0
4v04A-3h4jB:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
5 / 12 LEU B  40
GLY B  41
VAL B  48
ALA B  61
ALA B 173
None
0.71A 5xv7A-3h4jB:
16.1
5xv7A-3h4jB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
5 / 12 GLY B 133
LEU B 164
ILE B 122
HIS B  93
LEU B 293
None
1.18A 5y2tA-3h4jB:
undetectable
5y2tA-3h4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomy
ces
pombe)
5 / 12 GLY B 133
LEU B 164
ILE B 122
HIS B  93
TYR B 292
None
1.19A 6md4A-3h4jB:
undetectable
6md4A-3h4jB:
12.50