SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  62
ALA A  58
VAL A 176
LEU A 131
TYR A 210
 None
None
None
ANP  A 397 (-3.9A)
None
 1.37A 1qabE-3h4lA:
undetectable		 1qabE-3h4lA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  65
SER A  66
ASP A  68
ASP A  90
THR A 174
 ANP  A 397 ( 2.6A)
ANP  A 397 ( 4.0A)
None
ANP  A 397 (-3.6A)
ANP  A 397 (-3.7A)
 0.37A 1s14A-3h4lA:
15.4		 1s14A-3h4lA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.90A 2eikC-3h4lA:
undetectable
2eikJ-3h4lA:
undetectable		 2eikC-3h4lA:
19.18
2eikJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.89A 2eilC-3h4lA:
undetectable
2eilJ-3h4lA:
undetectable		 2eilC-3h4lA:
19.18
2eilJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.86A 3asnC-3h4lA:
undetectable
3asnJ-3h4lA:
undetectable		 3asnC-3h4lA:
19.18
3asnJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 206
GLY A 209
PRO A 320
LYS A 202
 None
 0.94A 3bjwC-3h4lA:
undetectable		 3bjwC-3h4lA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 138
LEU A 185
GLY A  49
THR A 109
 None
 0.87A 3dl9A-3h4lA:
undetectable		 3dl9A-3h4lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  65
SER A  66
ASP A  68
ASP A  90
THR A 174
 ANP  A 397 ( 2.6A)
ANP  A 397 ( 4.0A)
None
ANP  A 397 (-3.6A)
ANP  A 397 (-3.7A)
 0.30A 3lpsA-3h4lA:
16.8		 3lpsA-3h4lA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 261
VAL A 293
LEU A 349
GLY A 295
VAL A 345
 None
 1.12A 3ls4H-3h4lA:
undetectable		 3ls4H-3h4lA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 9 ARG A 292
THR A 382
LEU A 351
GLU A 350
GLY A 295
 None
 1.24A 3nxuB-3h4lA:
undetectable		 3nxuB-3h4lA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.76A 3x2qC-3h4lA:
undetectable
3x2qJ-3h4lA:
undetectable		 3x2qC-3h4lA:
19.18
3x2qJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.76A 3x2qP-3h4lA:
undetectable
3x2qW-3h4lA:
undetectable		 3x2qP-3h4lA:
19.18
3x2qW-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  86
THR A 174
LEU A  62
LEU A 103
LEU A 131
 None
ANP  A 397 (-3.7A)
None
ANP  A 397 (-4.7A)
ANP  A 397 (-3.9A)
 1.46A 4qynB-3h4lA:
undetectable		 4qynB-3h4lA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 11 ASN A  65
SER A  66
ASP A  68
ASP A  90
THR A 174
 ANP  A 397 ( 2.6A)
ANP  A 397 ( 4.0A)
None
ANP  A 397 (-3.6A)
ANP  A 397 (-3.7A)
 0.27A 4urnA-3h4lA:
16.5		 4urnA-3h4lA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 11 ASN A  65
SER A  66
ASP A  68
ASP A  90
THR A 174
 ANP  A 397 ( 2.6A)
ANP  A 397 ( 4.0A)
None
ANP  A 397 (-3.6A)
ANP  A 397 (-3.7A)
 0.33A 4urnB-3h4lA:
15.9		 4urnB-3h4lA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 11 ASN A  65
SER A  66
ASP A  68
ASP A  90
THR A 174
 ANP  A 397 ( 2.6A)
ANP  A 397 ( 4.0A)
None
ANP  A 397 (-3.6A)
ANP  A 397 (-3.7A)
 0.33A 4urnC-3h4lA:
16.5		 4urnC-3h4lA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  65
SER A  66
ASP A  90
ILE A  95
THR A 174
 ANP  A 397 ( 2.6A)
ANP  A 397 ( 4.0A)
ANP  A 397 (-3.6A)
ANP  A 397 (-4.4A)
ANP  A 397 (-3.7A)
 0.55A 4uroD-3h4lA:
16.9		 4uroD-3h4lA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  68
TYR A 210
ASP A  64
ILE A 217
 None
 0.84A 4xjeA-3h4lA:
undetectable		 4xjeA-3h4lA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.81A 5b1aC-3h4lA:
undetectable
5b1aJ-3h4lA:
undetectable		 5b1aC-3h4lA:
19.18
5b1aJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.79A 5b1aP-3h4lA:
undetectable
5b1aW-3h4lA:
undetectable		 5b1aP-3h4lA:
19.18
5b1aW-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.75A 5b3sC-3h4lA:
undetectable
5b3sJ-3h4lA:
undetectable		 5b3sC-3h4lA:
19.18
5b3sJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.75A 5b3sP-3h4lA:
undetectable		 5b3sP-3h4lA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  68
TYR A 210
ASP A  64
ILE A 217
 None
 0.86A 5cfsA-3h4lA:
undetectable		 5cfsA-3h4lA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 245
SER A 248
SER A 247
 None
 0.72A 5gsnA-3h4lA:
undetectable		 5gsnA-3h4lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.72A 5iy5C-3h4lA:
undetectable
5iy5J-3h4lA:
undetectable		 5iy5C-3h4lA:
18.53
5iy5J-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.77A 5z84C-3h4lA:
undetectable
5z84J-3h4lA:
undetectable		 5z84C-3h4lA:
19.18
5z84J-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.79A 5z85C-3h4lA:
undetectable
5z85J-3h4lA:
undetectable		 5z85C-3h4lA:
19.18
5z85J-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.71A 5zcoC-3h4lA:
undetectable
5zcoJ-3h4lA:
undetectable		 5zcoC-3h4lA:
19.18
5zcoJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.76A 5zcqC-3h4lA:
undetectable
5zcqJ-3h4lA:
undetectable		 5zcqC-3h4lA:
19.18
5zcqJ-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3h4l DNA MISMATCH REPAIR
PROTEIN PMS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.80A 5zcqP-3h4lA:
undetectable
5zcqW-3h4lA:
undetectable		 5zcqP-3h4lA:
19.18
5zcqW-3h4lA:
10.66