SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 169
ILE A 172
LEU A 190
ILE A 313
ILE A 336
 None
ADP  A 439 (-4.7A)
None
None
None
 0.94A 1oipA-3h4mA:
3.8		 1oipA-3h4mA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 223
LEU A 220
GLY A 216
GLY A 173
 None
None
ADP  A 439 (-3.0A)
ADP  A 439 (-4.0A)
 0.82A 1rukH-3h4mA:
undetectable
1rukL-3h4mA:
undetectable		 1rukH-3h4mA:
18.73
1rukL-3h4mA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 173
VAL A 338
LEU A 219
LEU A 220
LEU A 380
 ADP  A 439 (-4.0A)
None
ADP  A 439 (-4.0A)
None
None
 1.35A 1ya4B-3h4mA:
undetectable		 1ya4B-3h4mA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 298
ILE A 326
ARG A 331
LEU A 322
GLY A 314
 None
 1.09A 2bxmA-3h4mA:
2.4		 2bxmA-3h4mA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 221
VAL A 186
ILE A 207
GLY A 314
ILE A 269
 None
 1.26A 3el4B-3h4mA:
undetectable		 3el4B-3h4mA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 276
ILE A 272
LEU A 322
ALA A 325
 None
 0.84A 3r9sC-3h4mA:
undetectable		 3r9sC-3h4mA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 172
GLU A 181
LEU A 209
VAL A 338
 ADP  A 439 (-4.7A)
None
None
None
 0.69A 3ua5B-3h4mA:
undetectable		 3ua5B-3h4mA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 353
GLY A 216
GLY A 377
LEU A 380
LEU A 220
 ADP  A 439 (-4.2A)
ADP  A 439 (-3.0A)
ADP  A 439 (-3.1A)
None
None
 1.13A 3vywB-3h4mA:
undetectable		 3vywB-3h4mA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 353
GLY A 216
GLY A 377
LEU A 380
LEU A 220
 ADP  A 439 (-4.2A)
ADP  A 439 (-3.0A)
ADP  A 439 (-3.1A)
None
None
 1.17A 3vywD-3h4mA:
undetectable		 3vywD-3h4mA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 6 THR A 215
GLY A 377
ILE A 349
LEU A 219
 ADP  A 439 (-4.6A)
ADP  A 439 (-3.1A)
ADP  A 439 ( 4.0A)
ADP  A 439 (-4.0A)
 1.07A 4acbC-3h4mA:
undetectable		 4acbC-3h4mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 255
PHE A 256
VAL A 235
ILE A 269
 None
 0.75A 4zzbC-3h4mA:
undetectable
4zzbD-3h4mA:
undetectable		 4zzbC-3h4mA:
22.42
4zzbD-3h4mA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 359
THR A 354
LEU A 350
ILE A 368
LEU A 380
 None
 1.41A 5g48B-3h4mA:
undetectable		 5g48B-3h4mA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A 368
ILE A 411
MET A 401
 None
 0.54A 5i9yA-3h4mA:
undetectable		 5i9yA-3h4mA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 275
LEU A 297
MET A 301
LEU A 298
 None
 1.00A 5u4sA-3h4mA:
undetectable		 5u4sA-3h4mA:
22.73