SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU a 130
MET a 127
LEU a 121
SER a 120
 None
 1.35A 1ee2B-3h4pa:
0.0		 1ee2B-3h4pa:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE a 133
ALA a 143
GLY a 145
TYR a 144
 None
 0.99A 1gfzA-3h4pa:
undetectable		 1gfzA-3h4pa:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE a 133
ALA a 143
GLY a 145
TYR a 144
 None
 1.04A 1l5qA-3h4pa:
undetectable		 1l5qA-3h4pa:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE a 133
ALA a 143
GLY a 145
TYR a 144
 None
 1.01A 1l7xA-3h4pa:
undetectable		 1l7xA-3h4pa:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE a 133
ALA a 143
GLY a 145
TYR a 144
 None
 0.99A 1l7xB-3h4pa:
undetectable		 1l7xB-3h4pa:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE a  13
LEU a  12
ALA a 116
GLY a 108
LEU a  40
 None
 1.06A 2a58A-3h4pa:
undetectable
2a58B-3h4pa:
undetectable		 2a58A-3h4pa:
22.92
2a58B-3h4pa:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE a  13
LEU a  12
ALA a 116
GLY a 108
LEU a  40
 None
 1.07A 2a58B-3h4pa:
undetectable
2a58C-3h4pa:
undetectable		 2a58B-3h4pa:
22.92
2a58C-3h4pa:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE a  13
LEU a  12
ALA a 116
GLY a 108
LEU a  40
 None
 1.06A 2a58D-3h4pa:
undetectable
2a58E-3h4pa:
undetectable		 2a58D-3h4pa:
22.92
2a58E-3h4pa:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA a  52
THR a   7
ALA a 143
ALA a 167
LEU a 118
 None
 1.14A 2nyrA-3h4pa:
undetectable		 2nyrA-3h4pa:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE a 133
ALA a 143
GLY a 145
TYR a 144
 None
 1.08A 3bcrA-3h4pa:
undetectable		 3bcrA-3h4pa:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		3 / 3 PRO a 141
PHE a 177
LYS a   7
 None
 0.99A 3bjwG-3h4pa:
1.1		 3bjwG-3h4pa:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE a 133
ALA a 143
GLY a 145
TYR a 144
 None
 1.00A 3dd1B-3h4pa:
undetectable		 3dd1B-3h4pa:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		6 / 11 THR a   7
ALA a  26
ALA a  33
ALA a  52
GLY a  53
SER a 138
 None
 1.03A 3mg0K-3h4pa:
28.5
3mg0L-3h4pa:
24.6		 3mg0K-3h4pa:
29.36
3mg0L-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		6 / 11 THR a   7
ALA a  26
ALA a  33
LYS a  39
ALA a  52
SER a 138
 None
 1.25A 3mg0K-3h4pa:
28.5
3mg0L-3h4pa:
24.6		 3mg0K-3h4pa:
29.36
3mg0L-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		6 / 12 THR a   7
ALA a  26
ALA a  33
ALA a  52
GLY a  53
SER a 138
 None
 0.99A 3mg0Y-3h4pa:
21.3
3mg0Z-3h4pa:
24.3		 3mg0Y-3h4pa:
29.36
3mg0Z-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		6 / 12 THR a   7
ALA a  26
ALA a  33
LYS a  39
ALA a  52
SER a 138
 None
 1.19A 3mg0Y-3h4pa:
21.3
3mg0Z-3h4pa:
24.3		 3mg0Y-3h4pa:
29.36
3mg0Z-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3h4p PROTEASOME SUBUNIT
ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A  79
GLY A  81
GLY A 167
ASP A  85
PHE A  69
 None
 1.19A 3tkaA-3h4pA:
undetectable		 3tkaA-3h4pA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA a  60
ARG a  63
LEU a  93
LEU a  65
ILE a  92
 None
 0.91A 3wdmD-3h4pa:
undetectable		 3wdmD-3h4pa:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA a 135
THR a 134
ILE a 142
GLY a 145
ALA a 167
 None
 1.10A 4qvqK-3h4pa:
28.5
4qvqL-3h4pa:
24.6		 4qvqK-3h4pa:
29.82
4qvqL-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 9 THR a   7
ALA a  26
ALA a  33
ILE a  51
GLY a  53
 None
 0.99A 4qvqK-3h4pa:
28.5
4qvqL-3h4pa:
24.6		 4qvqK-3h4pa:
29.82
4qvqL-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 9 THR a   7
ALA a  26
ALA a  33
LYS a  39
ILE a  51
 None
 1.05A 4qvqK-3h4pa:
28.5
4qvqL-3h4pa:
24.6		 4qvqK-3h4pa:
29.82
4qvqL-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA a 135
THR a 134
ILE a 142
GLY a 145
ALA a 167
 None
 1.10A 4qvqY-3h4pa:
16.3
4qvqZ-3h4pa:
24.4		 4qvqY-3h4pa:
29.82
4qvqZ-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 9 THR a   7
ALA a  26
ALA a  33
ILE a  51
GLY a  53
 None
 0.99A 4qvqY-3h4pa:
16.3
4qvqZ-3h4pa:
24.4		 4qvqY-3h4pa:
29.82
4qvqZ-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 9 THR a   7
ALA a  26
ALA a  33
LYS a  39
ILE a  51
 None
 1.05A 4qvqY-3h4pa:
16.3
4qvqZ-3h4pa:
24.4		 4qvqY-3h4pa:
29.82
4qvqZ-3h4pa:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		3 / 3 MET a 155
GLU a 159
LEU a 163
 None
 0.44A 4v2oB-3h4pa:
undetectable		 4v2oB-3h4pa:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA a 167
LEU a  40
LEU a 184
LEU a  20
THR a  50
 None
 1.25A 4zmeB-3h4pa:
undetectable		 4zmeB-3h4pa:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3h4p PROTEASOME SUBUNIT
ALPHA
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A  40
LEU A 193
THR A 164
ALA A  50
LEU A  49
ALA A  78
 None
 1.42A 5kpcA-3h4pA:
undetectable		 5kpcA-3h4pA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 197
THR A 196
ALA A 194
ALA A 201
ASP A  52
 None
 1.00A 5l5zK-3h4pA:
28.7
5l5zL-3h4pA:
24.3		 5l5zK-3h4pA:
22.47
5l5zL-3h4pA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3h4p PROTEASOME SUBUNIT
ALPHA
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 197
THR A 196
ALA A 194
ALA A 201
ASP A  52
 None
 1.00A 5l5zY-3h4pA:
28.7
5l5zZ-3h4pA:
24.4		 5l5zY-3h4pA:
22.47
5l5zZ-3h4pA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3h4p PROTEASOME SUBUNIT
BETA
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP a 197
GLU a 196
LEU a  20
ALA a 185
GLN a  59
 None
 0.87A 5m5cB-3h4pa:
undetectable		 5m5cB-3h4pa:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3h4p PROTEASOME SUBUNIT
ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A  82
GLY A  81
SER A  80
SER A 136
 None
 1.33A 5uunA-3h4pA:
undetectable		 5uunA-3h4pA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3h4p PROTEASOME SUBUNIT
ALPHA
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A  82
GLY A  81
SER A  80
SER A 136
 None
 1.31A 5uunB-3h4pA:
undetectable		 5uunB-3h4pA:
21.61