SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		5 / 12 LEU A 836
HIS A 833
GLU A 831
ASP A 736
GLY A 828
 None
 1.41A 1d4fA-3h4rA:
undetectable		 1d4fA-3h4rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		5 / 11 ASP A 846
LEU A 843
LEU A 630
PRO A 626
TYR A 629
 None
 1.49A 1mxfC-3h4rA:
undetectable		 1mxfC-3h4rA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		5 / 12 ASP A 846
LEU A 843
LEU A 630
PRO A 626
TYR A 629
 None
 1.47A 1p33A-3h4rA:
undetectable		 1p33A-3h4rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		5 / 12 ASP A 846
LEU A 843
LEU A 630
PRO A 626
TYR A 629
 None
 1.41A 1p33B-3h4rA:
undetectable		 1p33B-3h4rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		5 / 12 ASP A 846
LEU A 843
LEU A 630
PRO A 626
TYR A 629
 None
 1.50A 1p33C-3h4rA:
undetectable		 1p33C-3h4rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		4 / 5 LEU A 715
TRP A 756
LEU A 802
GLN A 719
 None
 1.13A 1p93D-3h4rA:
undetectable		 1p93D-3h4rA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		4 / 8 MET A 708
LEU A 715
VAL A 815
VAL A 655
 None
 0.85A 2bdmA-3h4rA:
undetectable		 2bdmA-3h4rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		4 / 8 ILE A 614
ASN A 835
TYR A 629
SER A 617
 None
 1.10A 2zw9B-3h4rA:
undetectable		 2zw9B-3h4rA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		5 / 12 ASP A 621
ASN A 835
GLN A 618
CYH A 743
ILE A 614
 None
 1.47A 3opeA-3h4rA:
undetectable		 3opeA-3h4rA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		4 / 5 GLU A 729
HIS A 652
LEU A 802
VAL A 760
 None
 1.20A 6bc9A-3h4rA:
undetectable		 6bc9A-3h4rA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3h4r EXODEOXYRIBONUCLEASE
8
(Escherichia
coli) 		4 / 7 HIS A 652
HIS A 727
GLU A 729
GLU A 659
 None
 1.31A 6mn4F-3h4rA:
undetectable		 6mn4F-3h4rA:
21.17