SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		4 / 6 ASP A 141
GLY A 132
ILE A  82
ARG A  85
 None
 0.71A 1mt1G-3h55A:
undetectable
1mt1J-3h55A:
undetectable		 1mt1G-3h55A:
9.42
1mt1J-3h55A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		4 / 7 ILE A  82
ARG A  85
ASP A 141
GLY A 132
 None
 0.71A 1mt1H-3h55A:
undetectable
1mt1K-3h55A:
undetectable		 1mt1H-3h55A:
14.18
1mt1K-3h55A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		4 / 8 ASP A 141
GLY A 132
ILE A  82
ARG A  85
 None
 0.75A 1n13A-3h55A:
undetectable
1n13F-3h55A:
undetectable		 1n13A-3h55A:
9.42
1n13F-3h55A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 12 ARG A  97
ILE A  77
LEU A 116
VAL A 150
LEU A  91
 None
 1.19A 1r30A-3h55A:
9.2		 1r30A-3h55A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 12 ARG A  97
ILE A  77
LEU A 116
VAL A 150
LEU A  91
 None
 1.18A 1r30B-3h55A:
10.2		 1r30B-3h55A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 12 ILE A 183
ALA A 142
MET A 172
LEU A  18
ILE A 208
 None
 1.43A 1y0xX-3h55A:
undetectable		 1y0xX-3h55A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		4 / 7 GLU A 164
PRO A 190
ARG A 165
GLY A 168
 NAG  A 624 ( 4.1A)
None
None
None
 1.22A 2hs1B-3h55A:
undetectable		 2hs1B-3h55A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		4 / 8 ILE A  82
ARG A  85
ASP A 141
GLY A 132
 None
 0.73A 2qqcH-3h55A:
undetectable
2qqcK-3h55A:
undetectable		 2qqcH-3h55A:
14.18
2qqcK-3h55A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 11 PHE A 145
ALA A 142
ARG A 165
GLU A 164
LEU A 155
 None
None
None
NAG  A 624 ( 4.1A)
None
 1.13A 2v0mA-3h55A:
undetectable		 2v0mA-3h55A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 11 PHE A 145
ALA A 142
ARG A 165
GLU A 164
LEU A 155
 None
None
None
NAG  A 624 ( 4.1A)
None
 1.13A 2v0mD-3h55A:
undetectable		 2v0mD-3h55A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		4 / 9 ILE A 118
ALA A 146
VAL A 150
LYS A 115
 None
None
None
CIT  A1100 (-2.7A)
 1.02A 2vufB-3h55A:
undetectable		 2vufB-3h55A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		3 / 3 GLY A 246
PRO A  27
LEU A 211
 None
 0.44A 3hcpB-3h55A:
2.8		 3hcpB-3h55A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 12 ILE A  77
ASP A 141
GLY A 123
LEU A  91
TYR A 169
 None
 1.09A 3pwwA-3h55A:
undetectable		 3pwwA-3h55A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 9 LEU A 229
LEU A 276
ILE A 296
GLN A 269
PHE A 341
 None
 1.17A 3tmzA-3h55A:
undetectable		 3tmzA-3h55A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		3 / 3 GLY A 394
SER A 393
TRP A 222
 None
 0.61A 4e7cD-3h55A:
undetectable		 4e7cD-3h55A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		5 / 12 PRO A 279
MET A 253
LEU A 281
GLY A 157
ASP A 156
 None
None
None
None
GLA  A1000 (-3.4A)
 1.42A 4mubA-3h55A:
undetectable		 4mubA-3h55A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		3 / 3 HIS A 235
GLU A 234
TRP A 231
 None
 0.89A 5odiD-3h55A:
undetectable		 5odiD-3h55A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		3 / 3 HIS A 235
GLU A 234
TRP A 231
 None
 0.90A 5odqD-3h55A:
undetectable		 5odqD-3h55A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		3 / 3 HIS A 235
GLU A 234
TRP A 231
 None
 0.86A 5odrD-3h55A:
undetectable		 5odrD-3h55A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens) 		3 / 3 ASP A  45
PHE A  36
ARG A 287
 None
 1.13A 5yw0A-3h55A:
undetectable		 5yw0A-3h55A:
23.71