SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 8 ASN A 134
THR A 140
ASP A 213
GLY A 138
 None
 1.02A 1bu5B-3h5cA:
undetectable		 1bu5B-3h5cA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 8 SER A  85
LEU A 123
LEU A 107
LEU A 120
 None
 0.86A 1eupA-3h5cA:
undetectable		 1eupA-3h5cA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 8 SER A 382
ILE A 380
GLY A 379
GLY A 252
 None
 0.69A 1me7A-3h5cA:
undetectable		 1me7A-3h5cA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B  93
ASP A 238
ASN A 419
 None
 0.77A 1nbhA-3h5cB:
undetectable		 1nbhA-3h5cB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B  93
ASP A 238
ASN A 419
 None
 0.73A 1nbhD-3h5cB:
undetectable		 1nbhD-3h5cB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A 362
ILE A 203
PHE A 174
MET A 172
PHE A 200
 None
 1.43A 1xomA-3h5cA:
undetectable		 1xomA-3h5cA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A 362
ILE A 203
PHE A 174
MET A 172
PHE A 200
 None
 1.44A 1xomB-3h5cA:
undetectable		 1xomB-3h5cA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 12 PHE A  79
LEU A 414
SER A  70
VAL A 280
LEU A 304
 None
 1.21A 2hc4A-3h5cA:
undetectable		 2hc4A-3h5cA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 11 LEU A 107
ILE A 103
MET A 334
LEU A 199
VAL A 212
 None
 1.48A 2n27A-3h5cA:
undetectable		 2n27A-3h5cA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A  65
LEU A 331
GLN A 323
LEU A 211
VAL A 358
 None
 1.32A 2qd4A-3h5cA:
undetectable		 2qd4A-3h5cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 6 PRO A 398
ILE A 243
ASN A  76
LEU A 422
 None
 1.19A 2wekB-3h5cA:
undetectable		 2wekB-3h5cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 11 GLY A  94
ALA A  95
ASP A 345
LEU A 209
ILE A 103
 None
 0.92A 3em4A-3h5cA:
undetectable		 3em4A-3h5cA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		3 / 3 ARG A  67
ASP A 298
GLN A  53
 None
 0.76A 3lcvB-3h5cA:
undetectable		 3lcvB-3h5cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		4 / 8 ASP A  74
LEU A 289
ASP B 246
ASP A 238
 None
 1.18A 3n2oC-3h5cA:
undetectable
3n2oD-3h5cA:
undetectable		 3n2oC-3h5cA:
22.19
3n2oD-3h5cA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 4 PHE A 413
TYR A 214
ARG A  72
LEU A  66
 None
 1.16A 3sueA-3h5cA:
0.0		 3sueA-3h5cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		4 / 5 TYR A 240
GLY B  96
ASP B  95
GLU B  92
 None
 0.94A 4nkvD-3h5cA:
undetectable		 4nkvD-3h5cA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		4 / 5 GLY B 164
LEU B 327
LEU B 222
LEU B 227
 None
 0.75A 4o8fA-3h5cB:
undetectable		 4o8fA-3h5cB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 11 LEU A 299
LEU A 304
ASN A 306
MET A 307
VAL A 280
 None
 1.17A 4x20D-3h5cA:
undetectable		 4x20D-3h5cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		5 / 10 LEU B 222
GLY B 329
VAL B 330
THR B 299
VAL B 348
 None
 1.20A 4yb6A-3h5cB:
undetectable
4yb6D-3h5cB:
undetectable		 4yb6A-3h5cB:
20.00
4yb6D-3h5cB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		5 / 10 LEU B 222
GLY B 329
VAL B 330
THR B 299
VAL B 348
 None
 1.22A 4yb6D-3h5cB:
undetectable
4yb6E-3h5cB:
undetectable		 4yb6D-3h5cB:
20.00
4yb6E-3h5cB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		5 / 10 LEU B 344
LEU B 222
GLY B 329
VAL B 330
THR B 299
 None
 1.18A 4yb6D-3h5cB:
undetectable
4yb6E-3h5cB:
undetectable		 4yb6D-3h5cB:
20.00
4yb6E-3h5cB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		3 / 3 ARG A 337
ILE A 339
PHE A 340
 None
 0.74A 5kirA-3h5cA:
undetectable		 5kirA-3h5cA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 10 PRO A  81
ILE A 367
LEU A 411
LEU A  66
PHE A 401
 None
 1.24A 5tixB-3h5cA:
undetectable		 5tixB-3h5cA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		3 / 3 TRP B 354
MET B 211
ASN B 220
 None
 1.33A 5uc1B-3h5cB:
undetectable		 5uc1B-3h5cB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3h5c VITAMIN K-DEPENDENT
PROTEIN Z
(Homo
sapiens) 		3 / 3 TRP B 354
MET B 211
ASN B 220
 None
 1.34A 5uc1A-3h5cB:
undetectable		 5uc1A-3h5cB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 8 ILE A 196
ARG A 364
VAL A 212
ASP A 201
 None
 1.03A 5vlmF-3h5cA:
undetectable		 5vlmF-3h5cA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 6 MET A 402
ASN A  76
VAL A  78
LEU A 414
 None
 1.47A 5xdhA-3h5cA:
undetectable
5xdhC-3h5cA:
undetectable		 5xdhA-3h5cA:
9.69
5xdhC-3h5cA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 5 MET A 402
ASN A  76
VAL A  78
LEU A 414
 None
 1.29A 5xdhB-3h5cA:
undetectable		 5xdhB-3h5cA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 5 MET A 402
ASN A  76
VAL A  78
LEU A 414
 None
 1.28A 5xdhD-3h5cA:
undetectable		 5xdhD-3h5cA:
9.69