SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 6 LEU A 120
ILE A  19
TYR A  26
VAL A  80
 None
 1.06A 1db1A-3h5iA:
undetectable		 1db1A-3h5iA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN
(Carboxydothermus
hydrogenoformans) 		4 / 6 GLY A  64
GLN A  66
VAL A  97
ALA A  68
 None
 1.02A 1p6kA-3h5iA:
undetectable		 1p6kA-3h5iA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 LEU A  82
THR A  83
ILE A 113
ILE A 115
VAL A 116
 None
 1.07A 1pkvA-3h5iA:
undetectable
1pkvB-3h5iA:
undetectable		 1pkvA-3h5iA:
22.22
1pkvB-3h5iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 11 ILE A 115
VAL A 116
LEU A  82
THR A  83
ILE A 113
 None
 1.05A 1pkvA-3h5iA:
undetectable
1pkvB-3h5iA:
undetectable		 1pkvA-3h5iA:
22.22
1pkvB-3h5iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN
(Carboxydothermus
hydrogenoformans) 		5 / 10 PRO A  49
ILE A   6
TYR A 100
LEU A 120
TYR A  28
 None
 1.08A 2ze2A-3h5iA:
0.0		 2ze2A-3h5iA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3h5i RESPONSE
REGULATOR/SENSORY
BOX PROTEIN/GGDEF
DOMAIN PROTEIN
(Carboxydothermus
hydrogenoformans) 		3 / 3 LYS A  13
LEU A  34
ALA A  16
 None
CL  A 140 (-4.2A)
None
 0.84A 4iizA-3h5iA:
undetectable		 4iizA-3h5iA:
17.61