SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  98
GLY A  68
PHE A  71
SER A  94
 None
 0.67A 1d0vA-3h5jA:
undetectable		 1d0vA-3h5jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  98
GLY A  68
PHE A  71
SER A  94
 None
 0.66A 1jhaA-3h5jA:
undetectable		 1jhaA-3h5jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  65
VAL A  12
GLY A  11
GLY A   9
LEU A  84
 None
 0.96A 2egvA-3h5jA:
undetectable		 2egvA-3h5jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  65
VAL A  12
GLY A  11
GLY A   9
LEU A  84
 None
 0.97A 2egvB-3h5jA:
undetectable		 2egvB-3h5jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 156
GLY A 166
SER A   1
GLY A 103
MET A  85
 None
EDO  A1301 (-3.5A)
None
None
None
 1.17A 2y6rC-3h5jA:
undetectable		 2y6rC-3h5jA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 127
ALA A 146
LEU A 151
LEU A 122
ARG A  15
 None
 1.19A 3ix9A-3h5jA:
undetectable		 3ix9A-3h5jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 146
LEU A 151
LEU A 122
ARG A  15
VAL A  66
 None
 1.18A 3ix9B-3h5jA:
undetectable		 3ix9B-3h5jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  71
GLN A 117
PHE A  43
 None
 0.82A 3rv5A-3h5jA:
undetectable		 3rv5A-3h5jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 126
GLU A 128
SER A 130
 None
 0.73A 4ccqA-3h5jA:
undetectable		 4ccqA-3h5jA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 153
ALA A 137
LEU A 163
PHE A   4
 None
None
EDO  A1301 (-4.4A)
None
 0.90A 4uymA-3h5jA:
undetectable		 4uymA-3h5jA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 149
ALA A 146
ARG A  15
ILE A 127
GLN A 129
 None
 1.21A 5hgcA-3h5jA:
undetectable		 5hgcA-3h5jA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  42
THR A  21
ARG A  32
ARG A  35
 None
None
EDO  A1307 (-3.8A)
None
 1.18A 6ew0B-3h5jA:
undetectable		 6ew0B-3h5jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  42
THR A  21
ARG A  32
ARG A  35
 None
None
EDO  A1307 (-3.8A)
None
 1.18A 6ew0D-3h5jA:
undetectable		 6ew0D-3h5jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  42
THR A  21
ARG A  32
ARG A  35
 None
None
EDO  A1307 (-3.8A)
None
 1.18A 6ew0H-3h5jA:
undetectable		 6ew0H-3h5jA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  42
THR A  21
ARG A  32
ARG A  35
 None
None
EDO  A1307 (-3.8A)
None
 1.18A 6ew0I-3h5jA:
undetectable		 6ew0I-3h5jA:
19.08