SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		4 / 8 GLN A 267
LEU A 251
LYS A 186
LEU A 242
 None
 1.13A 1hk3A-3h5oA:
undetectable		 1hk3A-3h5oA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		3 / 3 SER A 230
ASP A 225
ASP A 236
 None
 0.66A 2plwA-3h5oA:
undetectable		 2plwA-3h5oA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		3 / 3 ARG A 337
GLN A 267
PRO A 293
 None
 0.97A 2qhfA-3h5oA:
undetectable		 2qhfA-3h5oA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		6 / 11 THR A 133
MET A 155
ILE A 305
LEU A  89
ASN A 107
ILE A  92
 None
None
None
None
SO4  A   1 (-3.2A)
None
 1.30A 3a50B-3h5oA:
undetectable		 3a50B-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		6 / 11 THR A 133
MET A 155
ILE A 305
LEU A  89
ASN A 107
ILE A  92
 None
None
None
None
SO4  A   1 (-3.2A)
None
 1.35A 3a50C-3h5oA:
undetectable		 3a50C-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		6 / 12 THR A 133
MET A 155
ILE A 305
LEU A  89
ASN A 107
ILE A  92
 None
None
None
None
SO4  A   1 (-3.2A)
None
 1.31A 3a50E-3h5oA:
undetectable		 3a50E-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 11 THR A 133
MET A 155
ILE A 305
ASN A 107
ILE A  92
 None
None
None
SO4  A   1 (-3.2A)
None
 1.21A 3a51A-3h5oA:
undetectable		 3a51A-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 12 THR A 133
MET A 155
ILE A 305
ASN A 107
ILE A  92
 None
None
None
SO4  A   1 (-3.2A)
None
 1.18A 3a51C-3h5oA:
undetectable		 3a51C-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 12 THR A 133
MET A 155
ILE A 305
ASN A 107
ILE A  92
 None
None
None
SO4  A   1 (-3.2A)
None
 1.14A 3a51D-3h5oA:
undetectable		 3a51D-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 12 THR A 133
MET A 155
ILE A 305
ASN A 107
ILE A  92
 None
None
None
SO4  A   1 (-3.2A)
None
 1.17A 3a51E-3h5oA:
undetectable		 3a51E-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		4 / 6 LEU A 181
ALA A 259
ASP A 256
LEU A 295
 None
 1.00A 3rozA-3h5oA:
3.6		 3rozA-3h5oA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 11 ALA A 288
ILE A 177
ASP A 256
ALA A 259
VAL A 273
 None
 1.12A 3rukD-3h5oA:
undetectable		 3rukD-3h5oA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		4 / 8 ILE A 177
ILE A 189
PHE A 191
GLY A 193
 None
 0.84A 4hdlA-3h5oA:
undetectable		 4hdlA-3h5oA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 9 ALA A 250
ALA A 262
SER A 266
ALA A 280
SER A 338
 None
 1.32A 4twdA-3h5oA:
undetectable
4twdB-3h5oA:
undetectable
4twdC-3h5oA:
undetectable
4twdD-3h5oA:
undetectable
4twdE-3h5oA:
undetectable		 4twdA-3h5oA:
22.31
4twdB-3h5oA:
22.31
4twdC-3h5oA:
22.31
4twdD-3h5oA:
22.31
4twdE-3h5oA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 9 ALA A 259
ALA A 280
ALA A 250
ALA A 262
SER A 266
 None
 1.30A 4twdA-3h5oA:
undetectable
4twdB-3h5oA:
undetectable
4twdC-3h5oA:
undetectable
4twdD-3h5oA:
undetectable
4twdE-3h5oA:
undetectable		 4twdA-3h5oA:
22.31
4twdB-3h5oA:
22.31
4twdC-3h5oA:
22.31
4twdD-3h5oA:
22.31
4twdE-3h5oA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 9 ALA A 262
SER A 266
ALA A 259
ALA A 280
SER A 338
 None
 1.31A 4twdA-3h5oA:
undetectable
4twdB-3h5oA:
undetectable
4twdC-3h5oA:
undetectable
4twdD-3h5oA:
undetectable
4twdE-3h5oA:
undetectable		 4twdA-3h5oA:
22.31
4twdB-3h5oA:
22.31
4twdC-3h5oA:
22.31
4twdD-3h5oA:
22.31
4twdE-3h5oA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 12 GLY A 174
PHE A 252
PHE A 282
LEU A 196
PHE A 191
 None
 1.41A 5nknA-3h5oA:
undetectable		 5nknA-3h5oA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 12 ILE A  92
GLY A  91
VAL A 166
ILE A 305
MET A 155
 None
 0.90A 5ycnA-3h5oA:
undetectable		 5ycnA-3h5oA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		3 / 3 GLY A  91
VAL A 166
MET A 155
 None
 0.41A 5ycpA-3h5oA:
undetectable		 5ycpA-3h5oA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		3 / 3 LEU A 295
THR A  83
ASN A  82
 None
 0.63A 6baaE-3h5oA:
undetectable		 6baaE-3h5oA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		3 / 3 LEU A 295
THR A  83
ASN A  82
 None
 0.63A 6baaF-3h5oA:
undetectable		 6baaF-3h5oA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		3 / 3 LEU A 295
THR A  83
ASN A  82
 None
 0.64A 6baaG-3h5oA:
undetectable		 6baaG-3h5oA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		3 / 3 LEU A 295
THR A  83
ASN A  82
 None
 0.64A 6baaH-3h5oA:
undetectable		 6baaH-3h5oA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 11 LEU A  86
GLY A 306
ILE A  92
ILE A 105
ILE A  77
 None
 1.04A 6gp2A-3h5oA:
undetectable		 6gp2A-3h5oA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3h5o TRANSCRIPTIONAL
REGULATOR GNTR
(Chromobacterium
violaceum) 		5 / 11 LEU A  86
GLY A 306
ILE A  92
ILE A 105
ILE A  77
 None
 0.97A 6gp2B-3h5oA:
undetectable		 6gp2B-3h5oA:
12.46