SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 11 TYR A 434
SER A 460
HIS A 244
HIS A 352
ILE A 424
 None
None
ZN  A 501 ( 3.3A)
ZN  A 500 ( 3.2A)
None
 1.16A 1fmjA-3h68A:
0.0		 1fmjA-3h68A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 10 TYR A 434
SER A 460
HIS A 244
HIS A 352
ILE A 424
 None
None
ZN  A 501 ( 3.3A)
ZN  A 500 ( 3.2A)
None
 1.14A 1fmjB-3h68A:
0.6		 1fmjB-3h68A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 TYR A 434
SER A 460
HIS A 244
HIS A 352
ILE A 424
 None
None
ZN  A 501 ( 3.3A)
ZN  A 500 ( 3.2A)
None
 1.14A 1fmlA-3h68A:
undetectable		 1fmlA-3h68A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 TYR A 434
SER A 460
HIS A 244
HIS A 352
ILE A 424
 None
None
ZN  A 501 ( 3.3A)
ZN  A 500 ( 3.2A)
None
 1.14A 1fmlB-3h68A:
undetectable		 1fmlB-3h68A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 LEU A 286
GLY A 288
VAL A 186
MET A 191
LEU A 259
 None
 1.40A 1nhzA-3h68A:
undetectable		 1nhzA-3h68A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 ASP A 271
HIS A 304
HIS A 244
 ZN  A 500 (-2.8A)
NHC  A   1 (-3.5A)
ZN  A 501 ( 3.3A)
 0.63A 1oe1A-3h68A:
undetectable		 1oe1A-3h68A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 ASP A 271
HIS A 304
HIS A 244
 ZN  A 500 (-2.8A)
NHC  A   1 (-3.5A)
ZN  A 501 ( 3.3A)
 0.62A 1oe3A-3h68A:
undetectable		 1oe3A-3h68A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 ARG A 373
ASP A 383
ASP A 388
 None
 0.66A 2ejtA-3h68A:
undetectable		 2ejtA-3h68A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 THR A 306
LEU A 340
LEU A 220
HIS A 352
LEU A 385
 None
None
None
ZN  A 500 ( 3.2A)
None
 1.07A 2ouzA-3h68A:
undetectable		 2ouzA-3h68A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_1
(DIHYDROFOLATE
REDUCTASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		4 / 4 GLU A 329
GLN A 374
ASN A 308
ARG A 301
 None
 1.47A 2w3bA-3h68A:
0.0		 2w3bA-3h68A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		4 / 8 GLY A 354
HIS A 427
ILE A 424
ASN A 269
 None
ZN  A 500 ( 3.2A)
None
None
 0.93A 2x0pA-3h68A:
undetectable		 2x0pA-3h68A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 ASP A 271
HIS A 304
HIS A 244
 ZN  A 500 (-2.8A)
NHC  A   1 (-3.5A)
ZN  A 501 ( 3.3A)
 0.64A 2xxgA-3h68A:
undetectable		 2xxgA-3h68A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 ASP A 271
HIS A 304
HIS A 244
 ZN  A 500 (-2.8A)
NHC  A   1 (-3.5A)
ZN  A 501 ( 3.3A)
 0.65A 2xxgC-3h68A:
undetectable		 2xxgC-3h68A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 LEU A 223
VAL A 334
ARG A 371
 None
 0.73A 3b0wB-3h68A:
undetectable		 3b0wB-3h68A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 9 LEU A 194
GLU A 281
VAL A 280
ILE A 212
LEU A 213
 None
 1.49A 3fl9D-3h68A:
undetectable		 3fl9D-3h68A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		4 / 8 LEU A 256
PHE A 476
TYR A 461
TYR A 266
 None
 1.00A 3po7A-3h68A:
undetectable		 3po7A-3h68A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		4 / 6 VAL A 280
TYR A 323
TYR A 198
ILE A 212
 None
 1.21A 3q5sA-3h68A:
undetectable		 3q5sA-3h68A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 PHE A 268
GLN A 342
PHE A 254
 None
 0.82A 3rv5A-3h68A:
undetectable		 3rv5A-3h68A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		4 / 6 LEU A 213
LYS A 217
LEU A 330
GLU A 333
 None
 1.12A 4f3tA-3h68A:
undetectable		 4f3tA-3h68A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		3 / 3 ASP A 453
HIS A 481
LYS A 485
 None
 0.99A 4qzuD-3h68A:
undetectable		 4qzuD-3h68A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 GLU A 305
THR A 306
ASP A 271
GLY A 276
HIS A 244
 None
None
ZN  A 500 (-2.8A)
None
ZN  A 501 ( 3.3A)
 1.48A 5axdA-3h68A:
undetectable		 5axdA-3h68A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 GLU A 305
THR A 306
ASP A 271
GLY A 276
HIS A 244
 None
None
ZN  A 500 (-2.8A)
None
ZN  A 501 ( 3.3A)
 1.48A 5axdC-3h68A:
undetectable		 5axdC-3h68A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		4 / 6 GLU A 305
PHE A 335
GLU A 318
VAL A 319
 None
 1.36A 5h4dA-3h68A:
undetectable		 5h4dA-3h68A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 GLU A 305
THR A 306
ASP A 271
GLY A 276
HIS A 244
 None
None
ZN  A 500 (-2.8A)
None
ZN  A 501 ( 3.3A)
 1.46A 5m5kB-3h68A:
undetectable		 5m5kB-3h68A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		4 / 4 ASP A 271
HIS A 352
HIS A 427
HIS A 304
 ZN  A 500 (-2.8A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.2A)
NHC  A   1 (-3.5A)
 1.49A 5ncdD-3h68A:
undetectable		 5ncdD-3h68A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 SER A 403
ASN A 269
LEU A 300
ASP A 383
GLY A 354
 None
 1.22A 6dwnA-3h68A:
undetectable		 6dwnA-3h68A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens) 		5 / 12 SER A 403
ASN A 269
LEU A 300
ASP A 383
GLY A 354
 None
 1.15A 6dwnC-3h68A:
undetectable		 6dwnC-3h68A:
14.43