SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 155
LEU A 158
ILE A  79
LEU A  55
LEU A  59
 None
 1.17A 1errB-3h6eA:
undetectable		 1errB-3h6eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 10 LEU A 264
ASP A 285
LEU A 236
ILE A 260
ILE A 383
 None
 1.29A 1i18A-3h6eA:
undetectable
1i18B-3h6eA:
undetectable		 1i18A-3h6eA:
11.46
1i18B-3h6eA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 10 ILE A 383
LEU A 264
ASP A 285
LEU A 236
ILE A 260
 None
 1.28A 1i18A-3h6eA:
undetectable
1i18B-3h6eA:
undetectable		 1i18A-3h6eA:
11.46
1i18B-3h6eA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 5 ALA A 235
ASP A 422
ASP A  29
ASP A  10
 None
 1.16A 2nyuB-3h6eA:
undetectable		 2nyuB-3h6eA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 8 GLN A 130
ASP A 174
TYR A  94
CYH A 171
 None
 1.18A 2xz5A-3h6eA:
undetectable
2xz5C-3h6eA:
undetectable		 2xz5A-3h6eA:
19.51
2xz5C-3h6eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 8 GLN A 130
ASP A 174
TYR A  94
CYH A 171
 None
 1.17A 2xz5C-3h6eA:
undetectable
2xz5D-3h6eA:
undetectable		 2xz5C-3h6eA:
19.51
2xz5D-3h6eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 8 GLN A 130
ASP A 174
TYR A  94
SER A 118
 None
 1.10A 2xz5C-3h6eA:
undetectable
2xz5D-3h6eA:
undetectable		 2xz5C-3h6eA:
19.51
2xz5D-3h6eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 374
LEU A 408
ILE A 336
SER A 407
VAL A 329
 None
 1.33A 3aqiB-3h6eA:
undetectable		 3aqiB-3h6eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		3 / 3 SER A 129
ASP A 174
ASP A 123
 None
 0.81A 3iv6A-3h6eA:
undetectable		 3iv6A-3h6eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		3 / 3 SER A 129
ASP A 174
ASP A 123
 None
 0.79A 3iv6C-3h6eA:
undetectable		 3iv6C-3h6eA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.88A 3ln1A-3h6eA:
0.5		 3ln1A-3h6eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.90A 3ln1B-3h6eA:
undetectable		 3ln1B-3h6eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.90A 3ln1C-3h6eA:
undetectable		 3ln1C-3h6eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 8 SER A 184
PHE A 196
LEU A 134
ASP A 135
 None
 0.98A 3m0wE-3h6eA:
undetectable
3m0wF-3h6eA:
undetectable
3m0wG-3h6eA:
undetectable
3m0wH-3h6eA:
undetectable		 3m0wE-3h6eA:
12.02
3m0wF-3h6eA:
12.02
3m0wG-3h6eA:
12.02
3m0wH-3h6eA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 VAL A 223
LEU A  56
ILE A 213
ALA A 214
ALA A  63
 None
 0.98A 3mdvB-3h6eA:
undetectable		 3mdvB-3h6eA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 6 ASP A  93
LEU A  46
TYR A  94
GLU A  95
 None
 1.15A 3w9tB-3h6eA:
undetectable		 3w9tB-3h6eA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 VAL A 223
ALA A 155
LEU A 210
LEU A 209
LEU A  55
 None
 1.10A 4i1rA-3h6eA:
undetectable		 4i1rA-3h6eA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 6 THR A 257
LEU A 125
LEU A 281
GLU A 276
 None
 0.92A 4nc3A-3h6eA:
undetectable		 4nc3A-3h6eA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A  87
LEU A  82
GLY A  85
VAL A 141
MET A 142
 None
 1.37A 4oktA-3h6eA:
undetectable		 4oktA-3h6eA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.20A 4qvpH-3h6eA:
undetectable
4qvpI-3h6eA:
undetectable		 4qvpH-3h6eA:
20.84
4qvpI-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.19A 4qvyV-3h6eA:
undetectable
4qvyW-3h6eA:
undetectable		 4qvyV-3h6eA:
20.84
4qvyW-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 11 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.18A 4qw0H-3h6eA:
undetectable
4qw0I-3h6eA:
undetectable		 4qw0H-3h6eA:
20.84
4qw0I-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 11 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.20A 4qw0V-3h6eA:
undetectable
4qw0W-3h6eA:
undetectable		 4qw0V-3h6eA:
20.84
4qw0W-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.21A 4qw1H-3h6eA:
undetectable
4qw1I-3h6eA:
undetectable		 4qw1H-3h6eA:
20.84
4qw1I-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.19A 4qw1V-3h6eA:
undetectable
4qw1W-3h6eA:
undetectable		 4qw1V-3h6eA:
20.84
4qw1W-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 9 VAL A 400
LEU A 322
LEU A 447
ALA A 367
LEU A 370
 None
 1.12A 4rs0A-3h6eA:
undetectable		 4rs0A-3h6eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 5 ARG A 295
ARG A 300
GLY A 299
GLU A 303
 None
 1.27A 4z3oA-3h6eA:
undetectable
4z3oB-3h6eA:
undetectable		 4z3oA-3h6eA:
21.84
4z3oB-3h6eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 7 HIS A 172
GLY A 170
ASN A 283
HIS A 230
 None
 1.31A 5a5zC-3h6eA:
undetectable		 5a5zC-3h6eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		3 / 3 VAL A 269
THR A 267
ARG A 263
 None
 0.70A 5b2sB-3h6eA:
4.5		 5b2sB-3h6eA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		3 / 3 VAL A 269
THR A 267
ARG A 263
 None
 0.71A 5b2tB-3h6eA:
5.7		 5b2tB-3h6eA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 11 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.29A 5bxnV-3h6eA:
undetectable
5bxnW-3h6eA:
undetectable		 5bxnV-3h6eA:
20.84
5bxnW-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A  76
GLY A  78
GLY A 124
LEU A 125
ALA A 151
 None
 0.99A 5c0oG-3h6eA:
undetectable		 5c0oG-3h6eA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 6 ARG A 295
ARG A 300
GLY A 299
GLU A 303
 None
 1.05A 5cdqA-3h6eA:
undetectable
5cdqC-3h6eA:
undetectable
5cdqD-3h6eA:
undetectable		 5cdqA-3h6eA:
24.04
5cdqC-3h6eA:
24.04
5cdqD-3h6eA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.23A 5cz7V-3h6eA:
undetectable
5cz7W-3h6eA:
undetectable		 5cz7V-3h6eA:
20.84
5cz7W-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 229
GLY A 228
SER A  19
PHE A 425
LEU A 237
 None
 1.34A 5czyA-3h6eA:
undetectable		 5czyA-3h6eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 4 LEU A 226
ILE A  70
GLY A 228
ILE A   9
 None
 0.86A 5dzk3-3h6eA:
undetectable
5dzkm-3h6eA:
undetectable		 5dzk3-3h6eA:
3.45
5dzkm-3h6eA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 5 ILE A  70
GLY A 228
ILE A   9
LEU A 226
 None
 0.86A 5dzkB-3h6eA:
undetectable
5dzkI-3h6eA:
undetectable
5dzkW-3h6eA:
undetectable		 5dzkB-3h6eA:
18.99
5dzkI-3h6eA:
18.57
5dzkW-3h6eA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 5 ILE A  70
GLY A 228
ILE A   9
LEU A 226
 None
 0.89A 5dzki-3h6eA:
undetectable
5dzkj-3h6eA:
undetectable
5dzkx-3h6eA:
undetectable		 5dzki-3h6eA:
18.57
5dzkj-3h6eA:
18.57
5dzkx-3h6eA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 5 ILE A  70
GLY A 228
ILE A   9
LEU A 226
 None
 0.92A 5dzkd-3h6eA:
undetectable
5dzkk-3h6eA:
undetectable
5dzky-3h6eA:
undetectable		 5dzkd-3h6eA:
18.99
5dzkk-3h6eA:
18.57
5dzky-3h6eA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.84A 5jw1A-3h6eA:
undetectable		 5jw1A-3h6eA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 325
VAL A 400
ALA A 404
SER A 407
LEU A 408
 None
 0.79A 5kirA-3h6eA:
undetectable		 5kirA-3h6eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 5 GLU A 165
GLY A 170
SER A 168
GLY A  76
 None
 1.11A 5kprA-3h6eA:
7.1		 5kprA-3h6eA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 10 LEU A  46
GLY A  74
GLY A  12
ILE A  79
GLN A 130
 None
 0.93A 5l0zB-3h6eA:
undetectable		 5l0zB-3h6eA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.20A 5l5fH-3h6eA:
undetectable
5l5fI-3h6eA:
undetectable		 5l5fH-3h6eA:
20.84
5l5fI-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.20A 5l5fV-3h6eA:
undetectable
5l5fW-3h6eA:
undetectable		 5l5fV-3h6eA:
20.84
5l5fW-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.20A 5l5zV-3h6eA:
undetectable
5l5zW-3h6eA:
undetectable		 5l5zV-3h6eA:
20.84
5l5zW-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 SER A 168
ALA A 227
GLY A 228
ALA A 151
ASP A 231
 None
 1.17A 5l66V-3h6eA:
undetectable
5l66W-3h6eA:
undetectable		 5l66V-3h6eA:
20.84
5l66W-3h6eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 322
ALA A 366
PRO A 358
PHE A 362
ILE A 306
 None
 1.40A 5ljbA-3h6eA:
undetectable		 5ljbA-3h6eA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_1
(SULFOTRANSFERASE)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		4 / 4 TYR A  94
ASP A  93
ASP A 231
SER A  35
 None
 1.42A 5tiwA-3h6eA:
0.0		 5tiwA-3h6eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3h6e CARBOHYDRATE KINASE,
FGGY
(Novosphingobium
aromaticivorans) 		5 / 10 VAL A 223
ILE A 213
ALA A 214
ALA A  63
LEU A  59
 None
 0.95A 6h1lA-3h6eA:
undetectable		 6h1lA-3h6eA:
21.90