SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		4 / 7 ARG A  70
ASP A   4
GLY A   5
PHE A   6
 None
 0.80A 1rtsB-3h6qA:
undetectable		 1rtsB-3h6qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		4 / 5 VAL A 150
TRP A 133
ARG A 160
HIS A 121
 None
 1.45A 3zofB-3h6qA:
0.0		 3zofB-3h6qA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		3 / 3 TRP A 107
GLN A  58
THR A  65
 None
 0.89A 4m2xA-3h6qA:
undetectable		 4m2xA-3h6qA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		4 / 8 LEU A  10
THR A   8
ARG A  50
LEU A  43
 None
 0.97A 4qknA-3h6qA:
undetectable		 4qknA-3h6qA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		5 / 11 VAL A  38
VAL A 145
VAL A  90
ILE A 109
ILE A 122
 None
 1.11A 5e4dB-3h6qA:
undetectable		 5e4dB-3h6qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		5 / 11 VAL A  90
VAL A  38
VAL A 145
ILE A 163
ILE A   9
 None
 1.09A 5e4dB-3h6qA:
undetectable		 5e4dB-3h6qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		3 / 3 TYR A  91
TYR A 140
GLN A 144
 None
 1.08A 5jsdA-3h6qA:
undetectable
5jsdB-3h6qA:
undetectable		 5jsdA-3h6qA:
12.90
5jsdB-3h6qA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 3h6q MACROCYPIN 1A
(Macrolepiota
procera) 		3 / 3 TYR A  91
TYR A 140
GLN A 144
 None
 1.09A 5jsdB-3h6qA:
undetectable
5jsdC-3h6qA:
undetectable		 5jsdB-3h6qA:
12.90
5jsdC-3h6qA:
12.90