SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
8 / 12 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.35A 1lbcA-3h6tA:
44.1
1lbcC-3h6tA:
43.4
1lbcA-3h6tA:
100.00
1lbcC-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
9 / 9 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
ASP A 248
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
None
CYZ  A 265 ( 4.4A)
0.46A 1lbcB-3h6tA:
43.6
1lbcB-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
8 / 12 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.37A 1lbcA-3h6tA:
44.1
1lbcC-3h6tA:
43.4
1lbcA-3h6tA:
100.00
1lbcC-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 11 LEU A 138
GLY A  62
ILE A  11
TYR A  16
PRO A  15
GLU  A 264 (-4.6A)
None
None
None
None
1.17A 1p91A-3h6tA:
undetectable
1p91A-3h6tA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 12 ALA A 189
GLY A 136
LEU A 191
PHE A 147
VAL A 154
None
1.34A 1vpoH-3h6tA:
undetectable
1vpoL-3h6tA:
undetectable
1vpoH-3h6tA:
20.36
1vpoL-3h6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 11 LEU A  39
ALA A 237
GLY A 231
ILE A  87
ILE A  43
None
0.83A 3ebzA-3h6tA:
undetectable
3ebzA-3h6tA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 10 ILE A  92
PRO A 105
SER A 108
SER A 217
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
None
0.64A 3ijxB-3h6tA:
42.8
3ijxD-3h6tA:
42.7
3ijxB-3h6tA:
100.00
3ijxD-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 5 LYS A 104
PRO A 105
LEU A 239
SER A 242
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
0.59A 3ijxH-3h6tA:
42.6
3ijxH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 5 LYS A 104
PRO A 105
SER A 108
LEU A 239
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
0.83A 3ijxH-3h6tA:
42.6
3ijxH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
6 / 10 ILE A  92
PRO A 105
SER A 108
SER A 217
LYS A 218
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
None
None
0.34A 3ik6B-3h6tA:
43.4
3ik6E-3h6tA:
43.5
3ik6B-3h6tA:
100.00
3ik6E-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
6 / 10 ILE A  92
PRO A 105
SER A 108
SER A 217
LYS A 218
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
None
None
0.61A 3ik6B-3h6tA:
43.4
3ik6E-3h6tA:
43.5
3ik6B-3h6tA:
100.00
3ik6E-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
8 / 12 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.57A 3iltB-3h6tA:
37.5
3iltE-3h6tA:
37.0
3iltB-3h6tA:
100.00
3iltE-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
8 / 10 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.57A 3iltB-3h6tA:
37.5
3iltE-3h6tA:
37.0
3iltB-3h6tA:
100.00
3iltE-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
3 / 3 ILE A  92
SER A 108
SER A 217
None
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
0.42A 3iltH-3h6tA:
36.8
3iltH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 10 LYS A 104
PRO A 105
SER A 108
LEU A 239
SER A 242
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
0.65A 3iluB-3h6tA:
43.8
3iluE-3h6tA:
43.3
3iluB-3h6tA:
100.00
3iluE-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
6 / 11 ILE A  92
PRO A 105
SER A 108
SER A 217
LYS A 218
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
None
None
0.57A 3iluB-3h6tA:
43.8
3iluE-3h6tA:
43.3
3iluB-3h6tA:
100.00
3iluE-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 5 LYS A 104
PRO A 105
LEU A 239
SER A 242
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
0.35A 3iluH-3h6tA:
43.1
3iluH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 5 LYS A 104
PRO A 105
SER A 108
LEU A 239
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
0.79A 3iluH-3h6tA:
43.1
3iluH-3h6tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
3 / 3 ALA A 134
ARG A 180
LYS A 183
None
1.12A 3kp5B-3h6tA:
undetectable
3kp5B-3h6tA:
18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
6 / 10 TYR A  35
PRO A 105
MET A 107
SER A 108
SER A 242
LEU A 247
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
0.32A 3lsfB-3h6tA:
43.6
3lsfE-3h6tA:
43.0
3lsfB-3h6tA:
100.00
3lsfE-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
6 / 10 PRO A 105
MET A 107
SER A 108
SER A 242
LEU A 247
LYS A 251
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.30A 3lsfB-3h6tA:
43.6
3lsfE-3h6tA:
43.0
3lsfB-3h6tA:
100.00
3lsfE-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 8 TYR A  35
MET A 107
SER A 108
ASP A 248
LYS A 251
None
None
CYZ  A 265 (-2.8A)
None
CYZ  A 265 ( 4.4A)
0.86A 3lsfH-3h6tA:
42.7
3lsfH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
7 / 8 TYR A  35
PRO A 105
MET A 107
SER A 108
SER A 242
LEU A 247
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.31A 3lsfH-3h6tA:
42.7
3lsfH-3h6tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 7 TYR A  35
MET A 107
LEU A 247
ASP A 248
LYS A 251
None
None
CYZ  A 265 (-4.3A)
None
CYZ  A 265 ( 4.4A)
0.96A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7
3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 8 ILE A  92
PRO A 105
SER A 108
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
None
0.38A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7
3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 8 ILE A  92
PRO A 105
SER A 217
GLY A 219
None
CYZ  A 265 (-3.9A)
GOL  A 270 ( 3.0A)
None
0.74A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7
3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 7 TYR A  35
MET A 107
ASP A 248
LYS A 251
None
None
None
CYZ  A 265 ( 4.4A)
1.08A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7
3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 7 TYR A  35
MET A 107
LEU A 247
LYS A 251
None
None
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.49A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7
3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 8 ILE A  92
PRO A 105
SER A 108
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
None
0.27A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7
3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 8 ILE A  92
PRO A 105
SER A 217
GLY A 219
None
CYZ  A 265 (-3.9A)
GOL  A 270 ( 3.0A)
None
0.68A 3lslA-3h6tA:
42.6
3lslD-3h6tA:
42.7
3lslA-3h6tA:
99.61
3lslD-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 6 TYR A  35
MET A 107
ASP A 248
LYS A 251
None
None
None
CYZ  A 265 ( 4.4A)
1.03A 3lslG-3h6tA:
42.1
3lslG-3h6tA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 6 TYR A  35
MET A 107
LEU A 247
LYS A 251
None
None
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.45A 3lslG-3h6tA:
42.1
3lslG-3h6tA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
3 / 3 ILE A 200
VAL A 178
ARG A 182
None
0.59A 3p73A-3h6tA:
undetectable
3p73A-3h6tA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 11 LEU A  39
ALA A 237
GLY A 231
ILE A  87
ILE A  43
None
0.87A 3s45B-3h6tA:
undetectable
3s45B-3h6tA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 12 LEU A  39
ALA A 237
GLY A 231
ILE A  87
ILE A  43
None
0.87A 3s54A-3h6tA:
undetectable
3s54A-3h6tA:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
8 / 9 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.26A 3tkdA-3h6tA:
44.2
3tkdA-3h6tA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 5 ILE A  92
PRO A 105
SER A 217
LYS A 218
GLY A 219
None
CYZ  A 265 (-3.9A)
GOL  A 270 ( 3.0A)
None
None
0.18A 3tkdB-3h6tA:
42.7
3tkdB-3h6tA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 5 ILE A  92
PRO A 105
SER A 217
LYS A 218
GLY A 219
None
CYZ  A 265 (-3.9A)
GOL  A 270 ( 3.0A)
None
None
0.17A 3tkdA-3h6tA:
44.2
3tkdA-3h6tA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
8 / 9 LYS A 104
PRO A 105
MET A 107
SER A 108
LEU A 239
SER A 242
LEU A 247
LYS A 251
None
CYZ  A 265 (-3.9A)
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-2.9A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.36A 3tkdB-3h6tA:
42.7
3tkdB-3h6tA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 7 THR A 224
LEU A 236
GLN A 244
LEU A 241
None
1.01A 4ib4A-3h6tA:
undetectable
4ib4A-3h6tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 4 THR A  93
ARG A 149
GLU A 145
VAL A  95
None
1.40A 4odoC-3h6tA:
undetectable
4odoC-3h6tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 12 LEU A  39
ALA A 237
GLY A 231
ILE A  87
ILE A  43
None
0.88A 5e5jB-3h6tA:
undetectable
5e5jB-3h6tA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 8 SER A 142
THR A  91
THR A  93
ILE A 111
GLU  A 264 (-3.2A)
GLU  A 264 (-4.2A)
None
None
1.04A 5jhdE-3h6tA:
undetectable
5jhdG-3h6tA:
undetectable
5jhdE-3h6tA:
21.55
5jhdG-3h6tA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 7 LEU A 127
THR A 143
TRP A 159
MET A 162
None
GLU  A 264 (-3.6A)
None
None
1.42A 5ljcA-3h6tA:
undetectable
5ljcA-3h6tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 8 GLY A  62
TYR A 190
ASP A 139
ASP A  65
None
1.05A 5vlmB-3h6tA:
undetectable
5vlmB-3h6tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
4 / 7 GLY A  62
TYR A 190
ASP A 139
ASP A  65
None
1.10A 5vlmE-3h6tA:
undetectable
5vlmE-3h6tA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 10 ILE A  92
PRO A 105
SER A 108
SER A 217
GLY A 219
None
CYZ  A 265 (-3.9A)
CYZ  A 265 (-2.8A)
GOL  A 270 ( 3.0A)
None
0.54A 5weoA-3h6tA:
8.2
5weoD-3h6tA:
7.2
5weoA-3h6tA:
34.03
5weoD-3h6tA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 10 MET A 107
SER A 108
LEU A 239
LEU A 247
LYS A 251
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.76A 6dm0B-3h6tA:
35.3
6dm0C-3h6tA:
21.2
6dm0B-3h6tA:
15.44
6dm0C-3h6tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 9 MET A 107
SER A 108
LEU A 239
LEU A 247
LYS A 251
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.77A 6dm0A-3h6tA:
21.2
6dm0D-3h6tA:
1.4
6dm0A-3h6tA:
15.44
6dm0D-3h6tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 10 MET A 107
SER A 108
LEU A 239
LEU A 247
LYS A 251
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.76A 6dm2B-3h6tA:
35.6
6dm2C-3h6tA:
29.1
6dm2B-3h6tA:
15.44
6dm2C-3h6tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
3h6t GLUTAMATE RECEPTOR 2
(Rattus
norvegicus)
5 / 10 MET A 107
SER A 108
LEU A 239
LEU A 247
LYS A 251
None
CYZ  A 265 (-2.8A)
CYZ  A 265 (-4.7A)
CYZ  A 265 (-4.3A)
CYZ  A 265 ( 4.4A)
0.76A 6dm2A-3h6tA:
29.1
6dm2D-3h6tA:
35.9
6dm2A-3h6tA:
15.44
6dm2D-3h6tA:
15.44