SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 6 PHE A 660
GLY A 614
SER A 611
THR A 599
 None
 1.09A 1icuA-3h6zA:
undetectable
1icuB-3h6zA:
undetectable		 1icuA-3h6zA:
19.32
1icuB-3h6zA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 5 PHE A 660
GLY A 614
SER A 611
THR A 599
 None
 1.15A 1icuC-3h6zA:
undetectable
1icuD-3h6zA:
undetectable		 1icuC-3h6zA:
19.32
1icuD-3h6zA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 6 PHE A 660
GLY A 614
SER A 611
THR A 599
 None
 1.01A 1kqbC-3h6zA:
undetectable
1kqbD-3h6zA:
undetectable		 1kqbC-3h6zA:
18.86
1kqbD-3h6zA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 12 LEU A 609
ALA A 629
VAL A 966
LEU A 539
PHE A 622
 None
 1.17A 1s9pB-3h6zA:
undetectable		 1s9pB-3h6zA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 10 SER A 724
ALA A 707
PHE A 722
ALA A 751
ARG A 700
 None
 1.17A 2bxqA-3h6zA:
undetectable		 2bxqA-3h6zA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		3 / 3 THR A 819
PRO A 817
TYR A 884
 None
 0.84A 2dxrA-3h6zA:
undetectable		 2dxrA-3h6zA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 7 PHE A 728
ALA A 707
ASP A 726
TYR A 721
 SUC  A   1 (-3.4A)
None
None
None
 1.08A 2e5dA-3h6zA:
undetectable
2e5dB-3h6zA:
undetectable		 2e5dA-3h6zA:
21.91
2e5dB-3h6zA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 7 ASP A 726
TYR A 721
PHE A 728
ALA A 707
 None
None
SUC  A   1 (-3.4A)
None
 1.07A 2e5dA-3h6zA:
undetectable
2e5dB-3h6zA:
undetectable		 2e5dA-3h6zA:
21.91
2e5dB-3h6zA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		3 / 3 ARG A 922
ASP A 725
ASP A 723
 None
 0.87A 2ejtA-3h6zA:
undetectable		 2ejtA-3h6zA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 12 LEU A 693
SER A 734
CYH A 730
VAL A 704
LEU A 757
 None
 1.36A 2hc4A-3h6zA:
undetectable		 2hc4A-3h6zA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 7 ILE A 603
GLY A 605
LEU A 967
PHE A 675
 None
 1.02A 2vctD-3h6zA:
undetectable		 2vctD-3h6zA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 7 SER A 682
VAL A 552
TYR A 606
ILE A 679
 None
 0.93A 2x45C-3h6zA:
undetectable		 2x45C-3h6zA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 12 LEU A 693
SER A 734
CYH A 730
VAL A 704
LEU A 757
 None
 1.28A 2zlcA-3h6zA:
undetectable		 2zlcA-3h6zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 7 SER A 682
VAL A 552
TYR A 606
ILE A 679
 None
 0.96A 3bu1A-3h6zA:
undetectable		 3bu1A-3h6zA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 12 ASP A 953
TYR A 848
ILE A 833
TYR A 836
LEU A 918
 None
None
None
None
SUC  A   1 (-4.1A)
 1.35A 4a84A-3h6zA:
undetectable		 4a84A-3h6zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		3 / 3 ARG A 922
ASP A 725
ASP A 723
 None
 0.83A 4kicB-3h6zA:
undetectable		 4kicB-3h6zA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 11 LEU A 936
VAL A 807
SER A 852
PHE A 860
LEU A 804
 None
 1.39A 4lhmA-3h6zA:
undetectable		 4lhmA-3h6zA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 6 TYR A 789
ASN A 796
TYR A 828
LEU A 824
 None
 1.20A 4twdB-3h6zA:
undetectable
4twdC-3h6zA:
undetectable		 4twdB-3h6zA:
22.59
4twdC-3h6zA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 6 TYR A 789
ASN A 796
TYR A 828
LEU A 824
 None
 1.11A 4twdD-3h6zA:
undetectable
4twdE-3h6zA:
undetectable		 4twdD-3h6zA:
22.59
4twdE-3h6zA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 6 TYR A 789
ASN A 796
TYR A 828
LEU A 824
 None
 1.23A 4twdI-3h6zA:
undetectable
4twdJ-3h6zA:
undetectable		 4twdI-3h6zA:
22.59
4twdJ-3h6zA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 8 ARG A 759
VAL A 770
ASP A 773
ASP A 774
 None
 0.94A 4xqgA-3h6zA:
undetectable		 4xqgA-3h6zA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 8 ARG A 759
VAL A 770
ASP A 773
ASP A 774
 None
 0.94A 4xqgB-3h6zA:
undetectable		 4xqgB-3h6zA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		5 / 12 LEU A 542
VAL A 926
LEU A 972
GLY A 974
PRO A 975
 None
 1.21A 5ienA-3h6zA:
undetectable		 5ienA-3h6zA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		3 / 3 HIS A 748
ASN A 749
ALA A 751
 None
 0.79A 5n4tB-3h6zA:
undetectable		 5n4tB-3h6zA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 4 VAL A 939
LYS A 938
VAL A 807
ASN A 811
 None
 1.16A 5vc3A-3h6zA:
undetectable		 5vc3A-3h6zA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3h6z POLYCOMB PROTEIN
SFMBT
(Drosophila
melanogaster) 		4 / 8 TYR A 606
TRP A 564
THR A 553
LEU A 567
 None
 1.33A 6cnjD-3h6zA:
undetectable
6cnjE-3h6zA:
undetectable		 6cnjD-3h6zA:
10.93
6cnjE-3h6zA:
11.51