SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.35A 1hrkB-3h77A:
2.6		 1hrkB-3h77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 284
ASN A 287
ARG A  40
VAL A 282
 None
CSJ  A 112 ( 3.8A)
None
None
 1.11A 1u1jA-3h77A:
undetectable		 1u1jA-3h77A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 164
GLY A 139
THR A 296
ALA A 298
ALA A  58
 None
 1.02A 2gluB-3h77A:
undetectable		 2gluB-3h77A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  77
GLY A 114
VAL A 166
VAL A 134
VAL A 136
 None
CSJ  A 112 ( 4.5A)
None
None
None
 0.84A 2ieoB-3h77A:
undetectable		 2ieoB-3h77A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.36A 2pnjB-3h77A:
undetectable		 2pnjB-3h77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 124
ASP A 180
LEU A 181
ARG A 182
 None
 0.76A 2uyqA-3h77A:
undetectable		 2uyqA-3h77A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 140
ASN A  79
VAL A  78
CYH A 138
 None
 1.48A 3amuA-3h77A:
0.0		 3amuA-3h77A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 11 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.38A 3aqiA-3h77A:
undetectable		 3aqiA-3h77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  85
VAL A 141
LEU A  98
LEU A  54
 None
 0.82A 3kk6A-3h77A:
undetectable		 3kk6A-3h77A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 180
LEU A 119
LEU A 116
GLY A 322
MET A 240
 None
 1.35A 3n58A-3h77A:
undetectable		 3n58A-3h77A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		6 / 12 VAL A 141
VAL A 137
GLY A 164
ALA A 163
SER A  11
LEU A  54
 None
 1.49A 3rr3A-3h77A:
undetectable		 3rr3A-3h77A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		6 / 12 VAL A 141
VAL A 137
GLY A 164
ALA A 163
SER A  11
LEU A  54
 None
 1.50A 3rr3B-3h77A:
undetectable		 3rr3B-3h77A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 141
VAL A 137
GLY A 164
ALA A 163
SER A  11
 None
 1.11A 3rr3C-3h77A:
undetectable		 3rr3C-3h77A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 141
VAL A 137
GLY A 164
ALA A 163
SER A  11
 None
 1.10A 3rr3D-3h77A:
undetectable		 3rr3D-3h77A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 316
LEU A 119
GLY A 114
ALA A 323
ALA A 324
 CSJ  A 112 ( 3.2A)
None
CSJ  A 112 ( 4.5A)
None
None
 0.92A 3sufA-3h77A:
undetectable		 3sufA-3h77A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  97
PRO A  57
VAL A  56
ASP A  84
 None
 1.17A 3ufnA-3h77A:
undetectable
3ufnB-3h77A:
undetectable		 3ufnA-3h77A:
14.46
3ufnB-3h77A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.41A 3w1wB-3h77A:
undetectable		 3w1wB-3h77A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 109
TYR A 315
ASN A 287
 None
None
CSJ  A 112 ( 3.8A)
 0.85A 4ffwB-3h77A:
undetectable		 4ffwB-3h77A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 229
LEU A 233
VAL A 234
GLU A 269
 COW  A 350 (-3.6A)
None
None
None
 1.00A 4g24A-3h77A:
undetectable		 4g24A-3h77A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 8 MET A  55
PRO A 294
VAL A 295
GLY A 118
 None
 0.85A 4mk4A-3h77A:
2.4		 4mk4A-3h77A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 11 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.38A 4mk4B-3h77A:
undetectable		 4mk4B-3h77A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 SER A  82
LEU A 193
LEU A 155
SER A 143
ASN A 287
 None
CSJ  A 112 (-4.5A)
None
None
CSJ  A 112 ( 3.8A)
 1.21A 4yiaA-3h77A:
undetectable		 4yiaA-3h77A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 252
LYS A 277
HIS A 253
ILE A 304
 None
 1.06A 5a06A-3h77A:
undetectable		 5a06A-3h77A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 252
LYS A 277
HIS A 253
ILE A 304
 None
 1.04A 5a06D-3h77A:
undetectable		 5a06D-3h77A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 139
GLY A 162
GLY A 160
LEU A 142
ALA A 165
 None
 0.98A 5c0oG-3h77A:
undetectable		 5c0oG-3h77A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 298
LEU A   8
GLY A   7
ILE A 251
LEU A 241
 None
 1.06A 5oy01-3h77A:
undetectable
5oy07-3h77A:
undetectable		 5oy01-3h77A:
13.75
5oy07-3h77A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  50
VAL A  45
ALA A  58
LEU A 135
LEU A  98
 None
 1.27A 5x23A-3h77A:
undetectable		 5x23A-3h77A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 153
SER A 149
ASP A 150
ASN A 154
 COW  A 350 (-3.6A)
None
None
COW  A 350 (-3.0A)
 1.32A 6ag0A-3h77A:
0.3		 6ag0A-3h77A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 140
ASN A  79
VAL A  78
CYH A 138
 None
 1.36A 6aggZ-3h77A:
0.0		 6aggZ-3h77A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 140
ASN A  79
VAL A 137
CYH A 138
 None
 1.29A 6aggZ-3h77A:
0.0		 6aggZ-3h77A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 137
LEU A 135
GLY A  99
LEU A 100
GLN A  95
 None
 1.11A 6czmE-3h77A:
undetectable
6czmF-3h77A:
undetectable		 6czmE-3h77A:
24.28
6czmF-3h77A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 161
LEU A 155
SER A 156
PHE A 218
 None
None
None
CSJ  A 112 ( 4.0A)
 1.19A 6ekuA-3h77A:
undetectable		 6ekuA-3h77A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 3h77 PQS BIOSYNTHETIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 180
LEU A 119
LEU A 116
GLY A 322
MET A 240
 None
 1.34A 6f3nC-3h77A:
undetectable		 6f3nC-3h77A:
21.44