SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CBR_A_REAA200_1 (CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	LEU A 236 ALA A 98 VAL A 251 LEU A 113 TYR A 137	None	1.18A	1cbrA-3h7fA: undetectable	1cbrA-3h7fA: 15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CBR_B_REAB200_1 (CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	LEU A 236 ALA A 98 VAL A 251 LEU A 113 TYR A 137	None	1.18A	1cbrB-3h7fA: undetectable	1cbrB-3h7fA: 15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174	None None LLP A 227 ( 3.6A) None None None	0.94A	1dfoA-3h7fA: 54.3	1dfoA-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None LLP A 227 ( 3.6A) None None None None	1.36A	1dfoA-3h7fA: 54.3	1dfoA-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174	None None LLP A 227 ( 3.6A) None None None	0.94A	1dfoB-3h7fA: 55.9	1dfoB-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None LLP A 227 ( 3.6A) None None None None	1.36A	1dfoB-3h7fA: 55.9	1dfoB-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174	None None LLP A 227 ( 3.6A) None None None	0.94A	1dfoC-3h7fA: 55.9	1dfoC-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None LLP A 227 ( 3.6A) None None None None	1.36A	1dfoC-3h7fA: 55.9	1dfoC-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174	None None LLP A 227 ( 3.6A) None None None	0.94A	1dfoD-3h7fA: 54.4	1dfoD-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	6 / 12	LEU A 118 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None LLP A 227 ( 3.6A) None None None None	1.35A	1dfoD-3h7fA: 54.4	1dfoD-3h7fA: 51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_FFOA1293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	7 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None None LLP A 227 ( 3.6A) None None None None	1.29A	1eqbA-3h7fA: 54.3	1eqbA-3h7fA: 51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 8	SER A 32 HIS A 123 SER A 173 HIS A 201	None LLP A 227 ( 3.6A) None LLP A 227 ( 4.2A)	0.74A	1eqbA-3h7fA: 54.3 1eqbB-3h7fA: 55.9	1eqbA-3h7fA: 51.43 1eqbB-3h7fA: 51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_FFOB2293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	7 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None None LLP A 227 ( 3.6A) None None None None	1.29A	1eqbB-3h7fA: 55.9	1eqbB-3h7fA: 51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 8	SER A 32 HIS A 123 SER A 173 HIS A 201	None LLP A 227 ( 3.6A) None LLP A 227 ( 4.2A)	0.74A	1eqbA-3h7fA: 54.3 1eqbB-3h7fA: 55.9	1eqbA-3h7fA: 51.43 1eqbB-3h7fA: 51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_FFOC3293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	7 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None None LLP A 227 ( 3.6A) None None None None	1.29A	1eqbC-3h7fA: 55.9	1eqbC-3h7fA: 51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 8	SER A 32 HIS A 123 SER A 173 HIS A 201	None LLP A 227 ( 3.6A) None LLP A 227 ( 4.2A)	0.75A	1eqbC-3h7fA: 55.9 1eqbD-3h7fA: 54.8	1eqbC-3h7fA: 51.43 1eqbD-3h7fA: 51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_FFOD4293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	7 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174 ARG A 363	None None LLP A 227 ( 3.6A) None None None None	1.29A	1eqbD-3h7fA: 54.8	1eqbD-3h7fA: 51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 8	SER A 32 HIS A 123 SER A 173 HIS A 201	None LLP A 227 ( 3.6A) None LLP A 227 ( 4.2A)	0.74A	1eqbC-3h7fA: 55.9 1eqbD-3h7fA: 54.8	1eqbC-3h7fA: 51.43 1eqbD-3h7fA: 51.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_B_CHDB1130_0 (FATTY ACID-BINDING PROTEIN)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	LEU A 336 LEU A 337 LEU A 328 ILE A 385 LEU A 401	None	1.16A	1tw4B-3h7fA: undetectable	1tw4B-3h7fA: 13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_A_URFA999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 5	ALA A 105 TYR A 243 ILE A 247 ASP A 219	None	1.08A	1upfA-3h7fA: undetectable	1upfA-3h7fA: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_B_URFB999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 7	ALA A 105 TYR A 243 ILE A 247 ASP A 219	None	0.93A	1upfB-3h7fA: 3.5	1upfB-3h7fA: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_C_URFC999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 5	ALA A 105 TYR A 243 ILE A 247 ASP A 219	None	0.98A	1upfC-3h7fA: 3.7	1upfC-3h7fA: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_B_SAMB1500_0 (ASPARTOKINASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 7	SER A 249 ARG A 60 LEU A 56 GLU A 72	None	1.09A	2cdqB-3h7fA: undetectable	2cdqB-3h7fA: 22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_FFOB505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	7 / 12	LEU A 118 GLY A 121 HIS A 123 LEU A 124 SER A 173 ALA A 174 ASN A 345	None None LLP A 227 ( 3.6A) None None None None	0.93A	2vmyA-3h7fA: 54.1	2vmyA-3h7fA: 55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_FFOB505_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	7 / 12	LEU A 118 HIS A 123 LEU A 124 SER A 173 ALA A 174 ASN A 345 ARG A 363	None LLP A 227 ( 3.6A) None None None None None	1.41A	2vmyA-3h7fA: 54.1	2vmyA-3h7fA: 55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2VMY_B_GLYB502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 8	SER A 32 HIS A 123 SER A 173 HIS A 201	None LLP A 227 ( 3.6A) None LLP A 227 ( 4.2A)	0.75A	2vmyA-3h7fA: 54.1 2vmyB-3h7fA: 54.0	2vmyA-3h7fA: 55.15 2vmyB-3h7fA: 55.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A25_A_SAMA279_0 (UNCHARACTERIZED PROTEIN PH0793)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	SER A 222 ASN A 99 ILE A 30 THR A 228 ASN A 345	None LLP A 227 ( 4.7A) None LLP A 227 ( 4.1A) None	1.12A	3a25A-3h7fA: 4.0	3a25A-3h7fA: 26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA602_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 7	ASN A 89 ALA A 75 ALA A 79 GLN A 91	None	0.71A	3a2qA-3h7fA: undetectable	3a2qA-3h7fA: 22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A51_E_VDYE6178_1 (VITAMIN D HYDROXYLASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	MET A 29 ILE A 364 ALA A 383 VAL A 302 LEU A 390	None	1.17A	3a51E-3h7fA: undetectable	3a51E-3h7fA: 24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ARU_A_PNXA607_1 (CHITINASE A)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 8	GLY A 375 GLU A 378 PHE A 412 GLY A 373	None	0.76A	3aruA-3h7fA: undetectable	3aruA-3h7fA: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B0W_B_DGXB1_1 (NUCLEAR RECEPTOR ROR-GAMMA)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	ALA A 218 VAL A 197 PHE A 202 LEU A 205 LEU A 229	None	1.36A	3b0wB-3h7fA: undetectable	3b0wB-3h7fA: 21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DLC_A_SAMA220_0 (PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	GLY A 235 GLY A 95 SER A 222 VAL A 90 ARG A 233	None LLP A 227 ( 3.2A) None None None	1.01A	3dlcA-3h7fA: undetectable	3dlcA-3h7fA: 16.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PGY_B_GLYB509_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 4	PHE A 35 THR A 371 LEU A 414 TYR A 415	None	0.39A	3pgyB-3h7fA: 51.3	3pgyB-3h7fA: 53.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PQZ_L_CCSL11_0 (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 CYCLIC PEPTIDE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 4	LEU A 205 TRP A 172 PHE A 181 PRO A 212	None	1.37A	3pqzD-3h7fA: 0.0 3pqzL-3h7fA: undetectable	3pqzD-3h7fA: 12.90 3pqzL-3h7fA: 2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PQZ_M_CCSM11_0 (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 CYCLIC PEPTIDE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	4 / 4	LEU A 205 TRP A 172 PHE A 181 PRO A 212	None	1.39A	3pqzC-3h7fA: 0.0 3pqzM-3h7fA: undetectable	3pqzC-3h7fA: 12.90 3pqzM-3h7fA: 2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C5L_B_PXLB300_1 (PHOSPHOMETHYLPYRIMID INE KINASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 9	GLY A 361 ALA A 333 GLY A 330 VAL A 321 VAL A 344	None	1.39A	4c5lB-3h7fA: 2.6	4c5lB-3h7fA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C5L_D_UEGD300_1 (PHOSPHOMETHYLPYRIMID INE KINASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 10	GLY A 361 ALA A 333 GLY A 330 VAL A 321 VAL A 344	None	1.41A	4c5lD-3h7fA: 6.1	4c5lD-3h7fA: 21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DUB_B_LDPB501_1 (CYTOCHROME P450 BM3 VARIANT 9D7)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 6	PHE A 279 ALA A 274 GLY A 231 LEU A 229 VAL A 225	None	1.37A	4dubB-3h7fA: undetectable	4dubB-3h7fA: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JEC_B_478B401_3 (HIV-1 PROTEASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	3 / 3	ASP A 198 LEU A 103 VAL A 251	LLP A 227 ( 2.9A) None None	0.57A	4jecB-3h7fA: undetectable	4jecB-3h7fA: 11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KRH_A_SAMA900_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	PHE A 83 GLY A 235 GLY A 95 SER A 222 ARG A 233	None None LLP A 227 ( 3.2A) None None	1.08A	4krhA-3h7fA: 2.8	4krhA-3h7fA: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KRH_B_SAMB900_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	PHE A 83 GLY A 235 GLY A 95 SER A 222 ARG A 233	None None LLP A 227 ( 3.2A) None None	1.09A	4krhB-3h7fA: 4.3	4krhB-3h7fA: 22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PCL_B_SAMB301_0 (O-METHYLTRANSFERASE FAMILY PROTEIN)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 12	GLN A 91 LEU A 260 GLY A 235 ALA A 200 ASN A 99	None None None LLP A 227 ( 3.6A) LLP A 227 ( 4.7A)	1.38A	4pclB-3h7fA: 5.2	4pclB-3h7fA: 18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	3h7f	SERINE HYDROXYMETHYLTRANSFE RASE 1 (Mycobacterium tuberculosis)	5 / 10	ALA A 387 LEU A 297 VAL A 302 VAL A 321 ALA A 333	None	1.43A	6h1lA-3h7fA: undetectable	6h1lA-3h7fA: 23.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CBR_A_REAA200_1","CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"LEU A 236;ALA A  98;VAL A 251;LEU A 113;TYR A 137","None","1.18A","1cbrA-3h7fA:undetectable","1cbrA-3h7fA:15.35"],["1CBR_B_REAB200_1","CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"LEU A 236;ALA A  98;VAL A 251;LEU A 113;TYR A 137","None","1.18A","1cbrB-3h7fA:undetectable","1cbrB-3h7fA:15.35"],["1DFO_A_FFOA1002_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174","None;None;LLP A 227 ( 3.6A);None;None;None","0.94A","1dfoA-3h7fA:54.3","1dfoA-3h7fA:51.66"],["1DFO_A_FFOA1002_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;LLP A 227 ( 3.6A);None;None;None;None","1.36A","1dfoA-3h7fA:54.3","1dfoA-3h7fA:51.66"],["1DFO_B_FFOB2002_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174","None;None;LLP A 227 ( 3.6A);None;None;None","0.94A","1dfoB-3h7fA:55.9","1dfoB-3h7fA:51.66"],["1DFO_B_FFOB2002_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;LLP A 227 ( 3.6A);None;None;None;None","1.36A","1dfoB-3h7fA:55.9","1dfoB-3h7fA:51.66"],["1DFO_C_FFOC3002_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174","None;None;LLP A 227 ( 3.6A);None;None;None","0.94A","1dfoC-3h7fA:55.9","1dfoC-3h7fA:51.66"],["1DFO_C_FFOC3002_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;LLP A 227 ( 3.6A);None;None;None;None","1.36A","1dfoC-3h7fA:55.9","1dfoC-3h7fA:51.66"],["1DFO_D_FFOD4002_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174","None;None;LLP A 227 ( 3.6A);None;None;None","0.94A","1dfoD-3h7fA:54.4","1dfoD-3h7fA:51.66"],["1DFO_D_FFOD4002_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",6,"LEU A 118;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;LLP A 227 ( 3.6A);None;None;None;None","1.35A","1dfoD-3h7fA:54.4","1dfoD-3h7fA:51.66"],["1EQB_A_FFOA1293_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",7,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;None;LLP A 227 ( 3.6A);None;None;None;None","1.29A","1eqbA-3h7fA:54.3","1eqbA-3h7fA:51.43"],["1EQB_A_GLYA1292_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"SER A  32;HIS A 123;SER A 173;HIS A 201","None;LLP A 227 ( 3.6A);None;LLP A 227 ( 4.2A)","0.74A","1eqbA-3h7fA:54.3;1eqbB-3h7fA:55.9","1eqbA-3h7fA:51.43;1eqbB-3h7fA:51.43"],["1EQB_B_FFOB2293_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",7,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;None;LLP A 227 ( 3.6A);None;None;None;None","1.29A","1eqbB-3h7fA:55.9","1eqbB-3h7fA:51.43"],["1EQB_B_GLYB2292_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"SER A  32;HIS A 123;SER A 173;HIS A 201","None;LLP A 227 ( 3.6A);None;LLP A 227 ( 4.2A)","0.74A","1eqbA-3h7fA:54.3;1eqbB-3h7fA:55.9","1eqbA-3h7fA:51.43;1eqbB-3h7fA:51.43"],["1EQB_C_FFOC3293_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",7,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;None;LLP A 227 ( 3.6A);None;None;None;None","1.29A","1eqbC-3h7fA:55.9","1eqbC-3h7fA:51.43"],["1EQB_C_GLYC3292_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"SER A  32;HIS A 123;SER A 173;HIS A 201","None;LLP A 227 ( 3.6A);None;LLP A 227 ( 4.2A)","0.75A","1eqbC-3h7fA:55.9;1eqbD-3h7fA:54.8","1eqbC-3h7fA:51.43;1eqbD-3h7fA:51.43"],["1EQB_D_FFOD4293_1","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",7,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174;ARG A 363","None;None;LLP A 227 ( 3.6A);None;None;None;None","1.29A","1eqbD-3h7fA:54.8","1eqbD-3h7fA:51.43"],["1EQB_D_GLYD4292_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"SER A  32;HIS A 123;SER A 173;HIS A 201","None;LLP A 227 ( 3.6A);None;LLP A 227 ( 4.2A)","0.74A","1eqbC-3h7fA:55.9;1eqbD-3h7fA:54.8","1eqbC-3h7fA:51.43;1eqbD-3h7fA:51.43"],["1TW4_B_CHDB1130_0","FATTY ACID-BINDING PROTEIN","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"LEU A 336;LEU A 337;LEU A 328;ILE A 385;LEU A 401","None","1.16A","1tw4B-3h7fA:undetectable","1tw4B-3h7fA:13.74"],["1UPF_A_URFA999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"ALA A 105;TYR A 243;ILE A 247;ASP A 219","None","1.08A","1upfA-3h7fA:undetectable","1upfA-3h7fA:19.65"],["1UPF_B_URFB999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"ALA A 105;TYR A 243;ILE A 247;ASP A 219","None","0.93A","1upfB-3h7fA:3.5","1upfB-3h7fA:19.65"],["1UPF_C_URFC999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"ALA A 105;TYR A 243;ILE A 247;ASP A 219","None","0.98A","1upfC-3h7fA:3.7","1upfC-3h7fA:19.65"],["2CDQ_B_SAMB1500_0","ASPARTOKINASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"SER A 249;ARG A  60;LEU A  56;GLU A  72","None","1.09A","2cdqB-3h7fA:undetectable","2cdqB-3h7fA:22.49"],["2VMY_B_FFOB505_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",7,"LEU A 118;GLY A 121;HIS A 123;LEU A 124;SER A 173;ALA A 174;ASN A 345","None;None;LLP A 227 ( 3.6A);None;None;None;None","0.93A","2vmyA-3h7fA:54.1","2vmyA-3h7fA:55.15"],["2VMY_B_FFOB505_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",7,"LEU A 118;HIS A 123;LEU A 124;SER A 173;ALA A 174;ASN A 345;ARG A 363","None;LLP A 227 ( 3.6A);None;None;None;None;None","1.41A","2vmyA-3h7fA:54.1","2vmyA-3h7fA:55.15"],["2VMY_B_GLYB502_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"SER A  32;HIS A 123;SER A 173;HIS A 201","None;LLP A 227 ( 3.6A);None;LLP A 227 ( 4.2A)","0.75A","2vmyA-3h7fA:54.1;2vmyB-3h7fA:54.0","2vmyA-3h7fA:55.15;2vmyB-3h7fA:55.15"],["3A25_A_SAMA279_0","UNCHARACTERIZED PROTEIN PH0793","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"SER A 222;ASN A  99;ILE A  30;THR A 228;ASN A 345","None;LLP A 227 ( 4.7A);None;LLP A 227 ( 4.1A);None","1.12A","3a25A-3h7fA:4.0","3a25A-3h7fA:26.67"],["3A2Q_A_ACAA602_1","6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"ASN A  89;ALA A  75;ALA A  79;GLN A  91","None","0.71A","3a2qA-3h7fA:undetectable","3a2qA-3h7fA:22.82"],["3A51_E_VDYE6178_1","VITAMIN D HYDROXYLASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"MET A  29;ILE A 364;ALA A 383;VAL A 302;LEU A 390","None","1.17A","3a51E-3h7fA:undetectable","3a51E-3h7fA:24.27"],["3ARU_A_PNXA607_1","CHITINASE A","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"GLY A 375;GLU A 378;PHE A 412;GLY A 373","None","0.76A","3aruA-3h7fA:undetectable","3aruA-3h7fA:22.72"],["3B0W_B_DGXB1_1","NUCLEAR RECEPTOR ROR-GAMMA","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"ALA A 218;VAL A 197;PHE A 202;LEU A 205;LEU A 229","None","1.36A","3b0wB-3h7fA:undetectable","3b0wB-3h7fA:21.06"],["3DLC_A_SAMA220_0","PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"GLY A 235;GLY A  95;SER A 222;VAL A  90;ARG A 233","None;LLP A 227 ( 3.2A);None;None;None","1.01A","3dlcA-3h7fA:undetectable","3dlcA-3h7fA:16.26"],["3PGY_B_GLYB509_0","SERINE HYDROXYMETHYLTRANSFERASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"PHE A  35;THR A 371;LEU A 414;TYR A 415","None","0.39A","3pgyB-3h7fA:51.3","3pgyB-3h7fA:53.17"],["3PQZ_L_CCSL11_0","GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7;CYCLIC PEPTIDE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"LEU A 205;TRP A 172;PHE A 181;PRO A 212","None","1.37A","3pqzD-3h7fA:0.0;3pqzL-3h7fA:undetectable","3pqzD-3h7fA:12.90;3pqzL-3h7fA:2.91"],["3PQZ_M_CCSM11_0","GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7;CYCLIC PEPTIDE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",4,"LEU A 205;TRP A 172;PHE A 181;PRO A 212","None","1.39A","3pqzC-3h7fA:0.0;3pqzM-3h7fA:undetectable","3pqzC-3h7fA:12.90;3pqzM-3h7fA:2.91"],["4C5L_B_PXLB300_1","PHOSPHOMETHYLPYRIMIDINE KINASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"GLY A 361;ALA A 333;GLY A 330;VAL A 321;VAL A 344","None","1.39A","4c5lB-3h7fA:2.6","4c5lB-3h7fA:21.63"],["4C5L_D_UEGD300_1","PHOSPHOMETHYLPYRIMIDINE KINASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"GLY A 361;ALA A 333;GLY A 330;VAL A 321;VAL A 344","None","1.41A","4c5lD-3h7fA:6.1","4c5lD-3h7fA:21.63"],["4DUB_B_LDPB501_1","CYTOCHROME P450 BM3 VARIANT 9D7","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"PHE A 279;ALA A 274;GLY A 231;LEU A 229;VAL A 225","None","1.37A","4dubB-3h7fA:undetectable","4dubB-3h7fA:23.12"],["4JEC_B_478B401_3","HIV-1 PROTEASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",3,"ASP A 198;LEU A 103;VAL A 251","LLP A 227 ( 2.9A);None;None","0.57A","4jecB-3h7fA:undetectable","4jecB-3h7fA:11.75"],["4KRH_A_SAMA900_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"PHE A  83;GLY A 235;GLY A  95;SER A 222;ARG A 233","None;None;LLP A 227 ( 3.2A);None;None","1.08A","4krhA-3h7fA:2.8","4krhA-3h7fA:22.72"],["4KRH_B_SAMB900_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE 2","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"PHE A  83;GLY A 235;GLY A  95;SER A 222;ARG A 233","None;None;LLP A 227 ( 3.2A);None;None","1.09A","4krhB-3h7fA:4.3","4krhB-3h7fA:22.72"],["4PCL_B_SAMB301_0","O-METHYLTRANSFERASE FAMILY PROTEIN","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"GLN A  91;LEU A 260;GLY A 235;ALA A 200;ASN A  99","None;None;None;LLP A 227 ( 3.6A);LLP A 227 ( 4.7A)","1.38A","4pclB-3h7fA:5.2","4pclB-3h7fA:18.76"],["6H1L_A_FJQA501_0","BIFUNCTIONAL CYTOCHROME P450\/NADPH--P450 REDUCTASE","3h7f","SERINE HYDROXYMETHYLTRANSFERASE 1","Mycobacterium tuberculosis",5,"ALA A 387;LEU A 297;VAL A 302;VAL A 321;ALA A 333","None","1.43A","6h1lA-3h7fA:undetectable","6h1lA-3h7fA:23.08"]]