SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 9 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.43A 1bkfA-3h7jA:
undetectable		 1bkfA-3h7jA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		4 / 7 LEU A 132
PHE A 218
SER A 214
MET A 188
 None
PPY  A 246 (-4.6A)
PPY  A 246 ( 3.7A)
None
 0.94A 1wrlA-3h7jA:
undetectable
1wrlB-3h7jA:
undetectable		 1wrlA-3h7jA:
18.38
1wrlB-3h7jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 9 TYR A  83
VAL A  89
ALA A  85
LEU A  65
MET A  76
 None
 1.48A 2qo5A-3h7jA:
1.5		 2qo5A-3h7jA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 12 LEU A 131
VAL A 137
ILE A 152
TYR A 177
MET A 179
 None
None
None
None
PPY  A 246 ( 4.3A)
 1.20A 2weyA-3h7jA:
undetectable		 2weyA-3h7jA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		4 / 5 PRO A 118
ILE A  84
PRO A  86
TYR A  83
 None
 1.04A 3d9lA-3h7jA:
undetectable
3d9lY-3h7jA:
undetectable		 3d9lA-3h7jA:
22.18
3d9lY-3h7jA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 12 GLN A 168
THR A 180
VAL A 181
ILE A 152
TYR A 177
 CO  A 245 ( 2.7A)
None
None
None
None
 1.38A 3elzC-3h7jA:
undetectable		 3elzC-3h7jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		4 / 6 GLN A  26
HIS A  52
HIS A  91
HIS A  50
 None
CO  A 244 (-3.3A)
CO  A 244 (-3.3A)
CO  A 244 (-3.3A)
 1.23A 3nvcA-3h7jA:
17.9		 3nvcA-3h7jA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 10 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.43A 3uf8A-3h7jA:
2.8		 3uf8A-3h7jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 10 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.44A 3uqaA-3h7jA:
2.3		 3uqaA-3h7jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		4 / 7 ASP A 178
GLY A 157
ILE A 152
THR A 185
 None
 0.87A 4acaC-3h7jA:
undetectable		 4acaC-3h7jA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 10 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.43A 4dz3A-3h7jA:
2.6		 4dz3A-3h7jA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 11 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.39A 5huaA-3h7jA:
2.3		 5huaA-3h7jA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 11 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.38A 5hwcA-3h7jA:
undetectable		 5hwcA-3h7jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		3 / 3 TRP A  20
GLU A  21
GLU A  48
 None
 0.82A 6fhwA-3h7jA:
undetectable		 6fhwA-3h7jA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		3 / 3 HIS A  52
HIS A  91
HIS A  50
 CO  A 244 (-3.3A)
CO  A 244 (-3.3A)
CO  A 244 (-3.3A)
 0.71A 6giqa-3h7jA:
undetectable		 6giqa-3h7jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		3 / 3 HIS A 164
HIS A 202
HIS A 162
 CO  A 245 ( 3.4A)
CO  A 245 ( 3.2A)
CO  A 245 ( 3.4A)
 0.70A 6giqa-3h7jA:
undetectable		 6giqa-3h7jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 10 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.43A 6mkeC-3h7jA:
2.3		 6mkeC-3h7jA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB
(Bacillus
subtilis) 		5 / 10 ASP A  33
PHE A 195
VAL A  36
ILE A 106
PHE A 219
 FE  A 248 (-2.2A)
None
None
None
None
 1.41A 6mkeD-3h7jA:
2.5		 6mkeD-3h7jA:
12.35