SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 PHE A  73
THR A  12
THR A  75
VAL A 174
GLY A 152
 EDO  A 505 (-4.9A)
None
None
None
None
 1.30A 1akdA-3h7rA:
undetectable		 1akdA-3h7rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		4 / 4 ILE A  54
LEU A  92
VAL A 104
ILE A 101
 None
 0.93A 1fm6D-3h7rA:
undetectable		 1fm6D-3h7rA:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		7 / 12 TYR A  24
TRP A  79
HIS A 110
GLU A 178
TYR A 202
SER A 203
GLN A 208
 ACT  A 501 ( 4.0A)
None
ACT  A 501 ( 4.0A)
None
NAP  A 401 (-3.1A)
NAP  A 401 (-2.8A)
NAP  A 401 (-3.6A)
 0.44A 1s2aA-3h7rA:
41.2		 1s2aA-3h7rA:
38.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 HIS A 198
HIS A 189
VAL A 265
THR A 245
TRP A 241
 None
 1.09A 1z9yA-3h7rA:
undetectable		 1z9yA-3h7rA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 PHE A  73
THR A  12
THR A  75
VAL A 174
GLY A 152
 EDO  A 505 (-4.9A)
None
None
None
None
 1.22A 2a1nA-3h7rA:
undetectable		 2a1nA-3h7rA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 10 PHE A  73
THR A  12
THR A  75
VAL A 174
GLY A 152
 EDO  A 505 (-4.9A)
None
None
None
None
 1.26A 2cp4A-3h7rA:
undetectable		 2cp4A-3h7rA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 THR A  12
ALA A 173
SER A 145
GLY A 146
ALA A 148
 None
None
EDO  A 508 ( 4.7A)
None
None
 1.20A 2f162-3h7rA:
undetectable		 2f162-3h7rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 THR A  12
ALA A 173
SER A 145
GLY A 146
ALA A 148
 None
None
EDO  A 508 ( 4.7A)
None
None
 1.20A 2f16N-3h7rA:
undetectable		 2f16N-3h7rA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 239
GLY A  20
GLY A  38
ILE A  37
VAL A 265
 None
EDO  A 502 ( 4.8A)
None
EDO  A 506 (-4.6A)
None
 0.95A 2ieoA-3h7rA:
undetectable		 2ieoA-3h7rA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 THR A  12
ALA A 173
SER A 145
GLY A 146
ALA A 148
 None
None
EDO  A 508 ( 4.7A)
None
None
 1.19A 3mg02-3h7rA:
undetectable
3mg0V-3h7rA:
undetectable		 3mg02-3h7rA:
19.70
3mg0V-3h7rA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 THR A  12
ALA A 173
SER A 145
GLY A 146
ALA A 148
 None
None
EDO  A 508 ( 4.7A)
None
None
 1.20A 3mg0N-3h7rA:
undetectable		 3mg0N-3h7rA:
19.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 12 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
TYR A 202
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
NAP  A 401 (-3.1A)
 0.33A 3r43A-3h7rA:
41.2		 3r43A-3h7rA:
39.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 12 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
TYR A 202
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
NAP  A 401 (-3.1A)
 0.32A 3r6iA-3h7rA:
40.5		 3r6iA-3h7rA:
39.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 10 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
 0.36A 3r7mA-3h7rA:
40.5		 3r7mA-3h7rA:
39.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 TYR A  48
HIS A 110
TRP A 111
CYH A 287
 ACT  A 501 ( 4.3A)
ACT  A 501 ( 4.0A)
NAP  A 401 ( 4.4A)
NAP  A 401 ( 4.6A)
 0.69A 3s3gA-3h7rA:
41.9		 3s3gA-3h7rA:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		7 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 155
TYR A 202
SER A 203
SER A 207
 ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
NAP  A 401 (-3.1A)
NAP  A 401 (-2.8A)
NAP  A 401 (-4.8A)
 0.43A 3ug8A-3h7rA:
40.5		 3ug8A-3h7rA:
39.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 12 TYR A  24
TRP A  79
HIS A 110
TYR A 202
SER A 203
SER A 207
 ACT  A 501 ( 4.0A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.1A)
NAP  A 401 (-2.8A)
NAP  A 401 (-4.8A)
 0.49A 3ugrA-3h7rA:
40.1		 3ugrA-3h7rA:
39.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 12 TYR A  24
TRP A  79
TYR A 202
SER A 203
SER A 207
PHE A 292
 ACT  A 501 ( 4.0A)
None
NAP  A 401 (-3.1A)
NAP  A 401 (-2.8A)
NAP  A 401 (-4.8A)
EDO  A 513 (-4.7A)
 0.98A 3ugrA-3h7rA:
40.1		 3ugrA-3h7rA:
39.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 TYR A  48
ASN A 155
GLU A 178
GLN A 208
 ACT  A 501 ( 4.3A)
NAP  A 401 (-3.4A)
None
NAP  A 401 (-3.6A)
 0.25A 3ugrA-3h7rA:
40.1		 3ugrA-3h7rA:
39.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 THR A 234
ALA A 235
LEU A 205
PHE A 278
ILE A 270
 None
NAP  A 401 (-3.2A)
NAP  A 401 (-4.0A)
None
None
 1.40A 4claA-3h7rA:
undetectable		 4claA-3h7rA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 10 TYR A  24
TYR A  48
HIS A 110
ASN A 155
TYR A 202
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
NAP  A 401 (-3.1A)
 0.26A 4jq4B-3h7rA:
40.9		 4jq4B-3h7rA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		4 / 8 TYR A  24
TYR A  48
TRP A  79
HIS A 110
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
 0.30A 4jtrA-3h7rA:
41.3		 4jtrA-3h7rA:
37.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 TYR A  24
TYR A  48
TRP A  79
HIS A 110
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
 0.36A 4jtrB-3h7rA:
41.2		 4jtrB-3h7rA:
37.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 106
LEU A 108
ASN A 175
VAL A 197
LEU A 161
LEU A 165
 None
 1.32A 4po0A-3h7rA:
undetectable		 4po0A-3h7rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 GLU A  51
TYR A  48
THR A  23
TYR A 107
 None
ACT  A 501 ( 4.3A)
None
None
 1.36A 4qwpA-3h7rA:
undetectable		 4qwpA-3h7rA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		4 / 5 GLU A  51
TYR A  48
THR A  23
TYR A 107
 None
ACT  A 501 ( 4.3A)
None
None
 1.36A 4qwpB-3h7rA:
undetectable		 4qwpB-3h7rA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
 0.38A 4yvpB-3h7rA:
41.5		 4yvpB-3h7rA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 9 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
TYR A 202
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
NAP  A 401 (-3.1A)
 0.40A 4yvvA-3h7rA:
41.0		 4yvvA-3h7rA:
39.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 9 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
 0.36A 4yvvB-3h7rA:
40.8		 4yvvB-3h7rA:
39.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 12 TYR A  24
TYR A  48
TRP A  79
HIS A 110
LEU A 115
ASN A 155
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
None
NAP  A 401 (-3.4A)
 0.51A 4yvxA-3h7rA:
40.7		 4yvxA-3h7rA:
39.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		6 / 12 TYR A  24
TYR A  48
TRP A  79
HIS A 110
LEU A 115
ASN A 155
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
None
NAP  A 401 (-3.4A)
 0.40A 4yvxB-3h7rA:
40.4		 4yvxB-3h7rA:
39.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_A_GCZA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 9 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
 0.46A 4zfcA-3h7rA:
41.0		 4zfcA-3h7rA:
39.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZFC_B_GCZB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 9 TYR A  24
TYR A  48
TRP A  79
HIS A 110
ASN A 155
 ACT  A 501 ( 4.0A)
ACT  A 501 ( 4.3A)
None
ACT  A 501 ( 4.0A)
NAP  A 401 (-3.4A)
 0.40A 4zfcB-3h7rA:
40.7		 4zfcB-3h7rA:
39.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 206
HIS A 247
SER A 279
ILE A 281
PHE A 278
 NAP  A 401 (-4.2A)
None
None
None
None
 1.23A 5igwA-3h7rA:
undetectable		 5igwA-3h7rA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 HIS A 198
VAL A  19
GLY A  20
ASP A  43
GLY A  22
 None
EDO  A 502 (-3.9A)
EDO  A 502 ( 4.8A)
NAP  A 401 (-3.7A)
NAP  A 401 (-3.2A)
 1.22A 5nnaC-3h7rA:
undetectable		 5nnaC-3h7rA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3h7r ALDO-KETO REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 HIS A 198
VAL A  19
GLY A  20
ASP A  43
GLY A  22
 None
EDO  A 502 (-3.9A)
EDO  A 502 ( 4.8A)
NAP  A 401 (-3.7A)
NAP  A 401 (-3.2A)
 1.22A 5nnaD-3h7rA:
undetectable		 5nnaD-3h7rA:
22.05