SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC8_0
(GRAMICIDIN A)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 4 VAL A 241
TRP A 236
VAL A 267
TRP A 231
 None
 1.31A 1c4dC-3h7vA:
undetectable
1c4dD-3h7vA:
undetectable		 1c4dC-3h7vA:
5.02
1c4dD-3h7vA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 7 GLY A  41
TYR A  30
ALA A  92
GLU A  44
 None
 0.80A 1dmaA-3h7vA:
undetectable		 1dmaA-3h7vA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		5 / 11 LEU A 162
ASN A 187
GLY A 186
TRP A 135
LEU A 152
 None
 1.40A 1fkpA-3h7vA:
undetectable		 1fkpA-3h7vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 8 LEU A 162
GLY A 186
TRP A 135
LEU A 152
 None
 1.00A 1s1xA-3h7vA:
undetectable		 1s1xA-3h7vA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 7 LEU A 162
PRO A 142
VAL A 137
MET A 140
 None
 1.34A 2hrcA-3h7vA:
undetectable		 2hrcA-3h7vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 8 ARG A  26
TRP A  51
ALA A 271
LEU A 272
 None
 1.04A 2o01A-3h7vA:
undetectable		 2o01A-3h7vA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 6 LEU A 307
ALA A 280
SER A  95
THR A  91
 None
 0.98A 3cfqA-3h7vA:
undetectable		 3cfqA-3h7vA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		5 / 12 VAL A 137
PHE A 179
PRO A 196
GLY A 168
LEU A 197
 None
 1.29A 3j6pB-3h7vA:
undetectable		 3j6pB-3h7vA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 6 GLY A  41
TYR A  30
ALA A  92
GLU A  44
 None
 0.97A 4ae1A-3h7vA:
undetectable		 4ae1A-3h7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		5 / 12 ALA A 271
GLU A  54
CYH A  63
PHE A  87
LEU A  82
 None
 1.15A 4qrcA-3h7vA:
undetectable		 4qrcA-3h7vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 7 TRP A 135
GLU A 145
GLU A 143
ARG A 177
 None
 1.46A 4r87J-3h7vA:
undetectable
4r87L-3h7vA:
undetectable		 4r87J-3h7vA:
19.08
4r87L-3h7vA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 4 LEU A 294
ILE A 108
PRO A 105
LEU A 306
 None
 1.20A 5eb3A-3h7vA:
undetectable		 5eb3A-3h7vA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		4 / 5 ILE A  78
LEU A  33
LYS A   1
HIS A  69
 None
 1.20A 5jmnB-3h7vA:
undetectable		 5jmnB-3h7vA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		5 / 10 SER A 125
ARG A 300
LEU A 111
GLY A 297
LEU A 205
 None
 1.22A 5oy01-3h7vA:
undetectable
5oy07-3h7vA:
undetectable		 5oy01-3h7vA:
13.77
5oy07-3h7vA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		3 / 3 GLU A 191
ARG A 163
TYR A 192
 None
 0.54A 5trqB-3h7vA:
undetectable		 5trqB-3h7vA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3h7v O-SUCCINYLBENZOATE
SYNTHASE
(Thermosynechococ
cus
elongatus) 		5 / 10 SER A 125
ARG A 300
LEU A 111
GLY A 297
LEU A 205
 None
 1.37A 6hqbA-3h7vA:
undetectable
6hqbJ-3h7vA:
undetectable		 6hqbA-3h7vA:
13.33
6hqbJ-3h7vA:
8.28