SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 10 LEU A 403
LEU A 392
THR A 390
ILE A 465
THR A 488
 None
 1.29A 1i18A-3h8fA:
undetectable
1i18B-3h8fA:
undetectable		 1i18A-3h8fA:
12.55
1i18B-3h8fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 10 THR A 488
LEU A 403
LEU A 392
THR A 390
ILE A 465
 None
 1.28A 1i18A-3h8fA:
undetectable
1i18B-3h8fA:
undetectable		 1i18A-3h8fA:
12.55
1i18B-3h8fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 ILE A 334
ALA A 432
LEU A 346
LEU A 354
PHE A 450
 None
 1.07A 1og5B-3h8fA:
undetectable		 1og5B-3h8fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 LEU A 130
LEU A 160
ALA A 111
LEU A  18
LEU A 100
 None
 1.29A 1s9pB-3h8fA:
undetectable		 1s9pB-3h8fA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 7 THR A  15
ALA A  70
LEU A  65
VAL A  13
 None
 1.00A 1tyrB-3h8fA:
undetectable		 1tyrB-3h8fA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 HIS A 175
ASP A 121
ASN A 119
 None
 0.82A 1wg8B-3h8fA:
2.5		 1wg8B-3h8fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 SER A 472
ALA A 375
ILE A 374
ILE A 465
ALA A 469
 None
 1.08A 2bxcA-3h8fA:
undetectable		 2bxcA-3h8fA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 ARG A 171
VAL A 304
THR A 488
 None
 0.86A 2nnkA-3h8fA:
undetectable		 2nnkA-3h8fA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 9 THR A  15
LEU A  74
THR A  17
ALA A 108
LEU A 112
 None
 1.27A 2npnA-3h8fA:
3.0		 2npnA-3h8fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 7 TYR A 127
VAL A 109
VAL A  31
ASP A 113
 None
 1.03A 2qbnA-3h8fA:
undetectable		 2qbnA-3h8fA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 ALA A 380
GLY A 391
GLY A 448
HIS A 462
LEU A 392
 None
 1.02A 2x1lB-3h8fA:
undetectable		 2x1lB-3h8fA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 7 LEU A 307
ALA A 303
LEU A 309
THR A 300
 None
 1.04A 3cfqA-3h8fA:
undetectable
3cfqB-3h8fA:
undetectable		 3cfqA-3h8fA:
14.25
3cfqB-3h8fA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 8 VAL A 484
GLY A 299
ARG A 302
GLY A 481
 None
 0.72A 3n9jB-3h8fA:
undetectable		 3n9jB-3h8fA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 LEU A 313
ILE A 372
PHE A 262
ALA A 370
GLY A 496
 None
 1.00A 3nxuA-3h8fA:
undetectable		 3nxuA-3h8fA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 ARG A 171
VAL A 304
THR A 488
 None
 0.82A 3pwrA-3h8fA:
undetectable		 3pwrA-3h8fA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 LEU A 307
LEU A 309
ALA A 303
THR A 300
LEU A 301
 None
 0.94A 3r9cA-3h8fA:
undetectable		 3r9cA-3h8fA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		6 / 12 LEU A 247
GLY A 266
ASP A 373
GLY A 352
ILE A 269
ILE A 226
 None
None
None
BCT  A 504 (-3.3A)
ZN  A 501 ( 4.8A)
None
 1.48A 3s54B-3h8fA:
undetectable		 3s54B-3h8fA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 9 VAL A  73
GLU A  71
GLY A  67
SER A  39
ALA A  38
 None
 1.16A 4fwdA-3h8fA:
2.0		 4fwdA-3h8fA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 5 ILE A 374
VAL A 297
PHE A 201
HIS A 462
 None
 1.23A 4rzvA-3h8fA:
undetectable		 4rzvA-3h8fA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 7 LYS A 224
LYS A 225
TYR A 235
PHE A 454
 None
 1.11A 4yv5A-3h8fA:
undetectable		 4yv5A-3h8fA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 MET A 393
LEU A 417
GLY A 293
THR A 444
LEU A 487
 None
 1.00A 5byjA-3h8fA:
undetectable		 5byjA-3h8fA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 LEU A 313
PHE A 234
ILE A 226
THR A 270
LEU A 202
 None
 1.15A 5eshA-3h8fA:
undetectable		 5eshA-3h8fA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 GLY A 401
GLY A 407
ASP A 412
ARG A 482
GLY A 394
 None
 0.96A 5hikA-3h8fA:
2.9		 5hikA-3h8fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 8 ALA A 108
VAL A 157
LEU A   3
VAL A  93
 None
 0.86A 5nujA-3h8fA:
undetectable		 5nujA-3h8fA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 8 THR A 158
TYR A 127
ASP A 114
GLY A 165
 None
 0.90A 5nzyA-3h8fA:
2.6		 5nzyA-3h8fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 LEU A 100
ASP A 107
ALA A 111
ARG A  72
LEU A  75
 None
 1.41A 5syfB-3h8fA:
undetectable		 5syfB-3h8fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 GLU A 138
TYR A 139
ARG A 187
 None
 0.64A 5uunA-3h8fA:
undetectable		 5uunA-3h8fA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 GLU A 138
TYR A 139
ARG A 187
 None
 0.55A 5uunB-3h8fA:
undetectable		 5uunB-3h8fA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		4 / 8 LEU A  61
VAL A  73
LEU A  52
ILE A  43
 None
 0.90A 5v0vA-3h8fA:
undetectable		 5v0vA-3h8fA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 THR A 390
THR A 468
ARG A 482
 None
 0.46A 5wm2A-3h8fA:
undetectable		 5wm2A-3h8fA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		5 / 12 ILE A 248
VAL A 265
LEU A 202
THR A 359
LEU A 189
 None
 1.22A 6b54A-3h8fA:
undetectable		 6b54A-3h8fA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 ARG A 246
LYS A 224
TYR A 235
 None
 1.34A 6gnaA-3h8fA:
undetectable		 6gnaA-3h8fA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3h8f CYTOSOL
AMINOPEPTIDASE
(Pseudomonas
putida) 		3 / 3 ARG A 246
LYS A 224
TYR A 235
 None
 1.34A 6gnbA-3h8fA:
undetectable		 6gnbA-3h8fA:
20.72