SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		5 / 12 LEU A 115
LEU A  68
ILE A  18
SER A  21
ALA A  24
 None
 1.14A 2bxpA-3h8wA:
undetectable		 2bxpA-3h8wA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 7 TYR A 121
PHE A 305
PHE A 290
ILE A  51
 None
 1.13A 2zseA-3h8wA:
undetectable		 2zseA-3h8wA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 6 VAL A  67
LEU A  48
ILE A 271
ILE A 122
 None
 0.91A 3gcsA-3h8wA:
undetectable		 3gcsA-3h8wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		5 / 12 ILE A 112
LEU A  25
GLN A  22
LEU A  46
VAL A 111
 None
 1.16A 3ix9A-3h8wA:
undetectable		 3ix9A-3h8wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 8 ILE A 152
ASP A  19
ILE A  23
PHE A  20
 None
 0.68A 4acaC-3h8wA:
undetectable		 4acaC-3h8wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 8 ILE A 152
ASP A  19
ILE A  23
PHE A  20
 None
 0.80A 4acbC-3h8wA:
undetectable		 4acbC-3h8wA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 8 LEU A 255
ASP A 259
ASP A 261
GLN A 160
 None
 0.96A 4umjA-3h8wA:
undetectable		 4umjA-3h8wA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 5 ASP A 259
ASP A 261
ARG A 236
GLN A 160
 None
 1.49A 6g31C-3h8wA:
undetectable		 6g31C-3h8wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 7 LEU A 255
ASP A 259
ASP A 261
GLN A 160
 None
 1.05A 6g31D-3h8wA:
undetectable		 6g31D-3h8wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 6 LEU A 255
ASP A 259
ASP A 261
GLN A 160
 None
 1.08A 6g31J-3h8wA:
undetectable		 6g31J-3h8wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3h8w RIBONUCLEASE H
(Escherichia
virus
T4) 		4 / 8 TYR A 104
PHE A  32
VAL A 111
SER A 107
 None
 1.02A 6huoC-3h8wA:
undetectable
6huoD-3h8wA:
undetectable		 6huoC-3h8wA:
12.54
6huoD-3h8wA:
14.57