SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  21
GLY A  23
ILE A  38
GLN A  27
PHE A  71
 None
 1.17A 2akeA-3h9jA:
undetectable		 2akeA-3h9jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  21
GLY A  23
ILE A  38
GLN A  27
PHE A  71
 None
 1.17A 2azxA-3h9jA:
2.8		 2azxA-3h9jA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  21
GLY A  23
ILE A  38
GLN A  27
PHE A  71
 None
 1.16A 2azxB-3h9jA:
2.9		 2azxB-3h9jA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 11 GLY A  21
GLY A  23
ILE A  38
GLN A  27
PHE A  71
 None
 1.16A 2dr2A-3h9jA:
undetectable		 2dr2A-3h9jA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		4 / 6 ASN A 154
GLN A 158
THR A 290
PRO A 288
 None
APC  A 359 (-3.7A)
None
None
 1.49A 2ez7A-3h9jA:
undetectable		 2ez7A-3h9jA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 319
VAL A 210
ALA A 298
CYH A 302
VAL A 306
 None
 1.39A 2g70A-3h9jA:
4.1		 2g70A-3h9jA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 319
VAL A 210
ALA A 298
CYH A 302
VAL A 306
 None
 1.41A 2g70B-3h9jA:
4.0		 2g70B-3h9jA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		4 / 6 PRO A 204
HIS A 201
ASP A 196
ASP A 199
 None
 1.39A 2lh8A-3h9jA:
undetectable		 2lh8A-3h9jA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 307
ILE A 310
GLY A 140
GLY A 138
SER A 137
 None
 0.97A 2yvlA-3h9jA:
5.4		 2yvlA-3h9jA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 300
ALA A 299
ASN A 128
VAL A 118
ILE A 142
 None
 1.01A 3e00A-3h9jA:
undetectable		 3e00A-3h9jA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		3 / 3 ASN A 154
ASP A 148
ARG A 285
 None
APC  A 359 (-3.0A)
None
 0.62A 3k13C-3h9jA:
undetectable		 3k13C-3h9jA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 GLN A 110
GLY A 138
GLY A 311
ALA A 303
ALA A 304
 None
 1.20A 3sueB-3h9jA:
undetectable		 3sueB-3h9jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		4 / 8 ILE A 139
ILE A 142
VAL A 210
GLY A 127
 None
 0.83A 4acaC-3h9jA:
3.3		 4acaC-3h9jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		4 / 6 GLU A  62
PHE A  65
ARG A  70
PHE A  69
 None
 1.02A 4uciA-3h9jA:
undetectable		 4uciA-3h9jA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		4 / 7 GLU A  62
PHE A  65
ARG A  70
PHE A  69
 None
 1.01A 4uciB-3h9jA:
undetectable		 4uciB-3h9jA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 127
GLY A 124
LEU A 160
VAL A 210
ALA A 298
 None
APC  A 359 (-3.0A)
None
None
None
 0.90A 5kpcA-3h9jA:
4.3		 5kpcA-3h9jA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3h9j MCCB PROTEIN
(Escherichia
coli) 		5 / 12 GLN A 110
GLY A 138
VAL A 132
GLY A 311
ALA A 304
 None
 1.15A 6c2mB-3h9jA:
undetectable		 6c2mB-3h9jA:
12.22