SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3h9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 ASP A 302
ARG A 342
ILE A  78
 None
 0.74A 1a4gB-3h9uA:
undetectable		 1a4gB-3h9uA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 7 LEU A  64
THR A 373
TRP A 372
ASN A 125
 None
 1.11A 1afsA-3h9uA:
undetectable		 1afsA-3h9uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 7 LEU A  64
THR A 373
TRP A 372
ASN A 125
 None
 1.10A 1afsB-3h9uA:
undetectable		 1afsB-3h9uA:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.36A 1d4fA-3h9uA:
61.4		 1d4fA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.34A 1d4fA-3h9uA:
61.4		 1d4fA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 THR A  57
GLU A 155
THR A 156
HIS A 300
HIS A 352
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 3.3A)
 0.69A 1d4fA-3h9uA:
61.4		 1d4fA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.44A 1d4fB-3h9uA:
61.6		 1d4fB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 LEU A  51
HIS A  52
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.42A 1d4fB-3h9uA:
61.6		 1d4fB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 THR A  54
THR A  57
GLU A 155
THR A 156
HIS A 352
 ADN  A 439 (-2.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
ADN  A 439 ( 3.3A)
 0.66A 1d4fB-3h9uA:
61.6		 1d4fB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.42A 1d4fC-3h9uA:
61.4		 1d4fC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 343
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.40A 1d4fC-3h9uA:
61.4		 1d4fC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 THR A  57
GLU A 155
THR A 156
HIS A 300
LEU A 346
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 4.7A)
 0.66A 1d4fC-3h9uA:
61.4		 1d4fC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
 1.36A 1d4fD-3h9uA:
61.5		 1d4fD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.37A 1d4fD-3h9uA:
61.5		 1d4fD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 THR A  57
GLU A 155
THR A 156
HIS A 300
HIS A 352
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 3.3A)
 0.66A 1d4fD-3h9uA:
61.5		 1d4fD-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 ILE A 294
THR A 273
ILE A 298
ASN A 345
LEU A 198
 None
None
NAD  A 438 (-4.4A)
NAD  A 438 (-2.9A)
None
 1.14A 1dhfB-3h9uA:
undetectable		 1dhfB-3h9uA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 LEU A 391
PRO A 392
LEU A 395
 None
 0.54A 1hrkA-3h9uA:
4.5		 1hrkA-3h9uA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 1v8bA-3h9uA:
55.1		 1v8bA-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.41A 1v8bA-3h9uA:
55.1		 1v8bA-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.41A 1v8bB-3h9uA:
55.1		 1v8bB-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.39A 1v8bB-3h9uA:
55.1		 1v8bB-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 1v8bC-3h9uA:
55.3		 1v8bC-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.28A 1v8bC-3h9uA:
55.3		 1v8bC-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 GLU A 155
THR A 156
LEU A 343
 None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.52A 1v8bC-3h9uA:
55.3		 1v8bC-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 1v8bD-3h9uA:
55.3		 1v8bD-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.43A 1v8bD-3h9uA:
55.3		 1v8bD-3h9uA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 ASP A 189
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.00A 1xwfA-3h9uA:
56.5		 1xwfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
HIS A 300
LEU A 346
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.05A 1xwfA-3h9uA:
56.5		 1xwfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
THR A  54
HIS A 300
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.00A 1xwfA-3h9uA:
56.5		 1xwfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A 300
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.75A 1xwfA-3h9uA:
56.5		 1xwfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
ASP A 130
ASP A 189
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.91A 1xwfA-3h9uA:
56.5		 1xwfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
ASP A 189
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.79A 1xwfA-3h9uA:
56.5		 1xwfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 ASP A 189
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.03A 1xwfB-3h9uA:
56.6		 1xwfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
HIS A 300
LEU A 346
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.03A 1xwfB-3h9uA:
56.6		 1xwfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
THR A  54
HIS A 300
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.95A 1xwfB-3h9uA:
56.6		 1xwfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A 300
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.72A 1xwfB-3h9uA:
56.6		 1xwfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
ASP A 130
ASP A 189
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.94A 1xwfB-3h9uA:
56.6		 1xwfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
ASP A 189
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.79A 1xwfB-3h9uA:
56.6		 1xwfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 ASP A 189
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.03A 1xwfC-3h9uA:
56.4		 1xwfC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
HIS A 300
LEU A 346
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.06A 1xwfC-3h9uA:
56.4		 1xwfC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
THR A  54
HIS A 300
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.01A 1xwfC-3h9uA:
56.4		 1xwfC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A 300
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.77A 1xwfC-3h9uA:
56.4		 1xwfC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
ASP A 130
ASP A 189
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.93A 1xwfC-3h9uA:
56.4		 1xwfC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
ASP A 189
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.80A 1xwfC-3h9uA:
56.4		 1xwfC-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 ASP A 189
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.04A 1xwfD-3h9uA:
56.4		 1xwfD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
HIS A 300
LEU A 346
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.09A 1xwfD-3h9uA:
56.4		 1xwfD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
THR A  54
HIS A 300
GLY A 351
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 1.02A 1xwfD-3h9uA:
56.4		 1xwfD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A 300
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.79A 1xwfD-3h9uA:
56.4		 1xwfD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 LEU A  51
HIS A  52
ASP A 130
ASP A 189
LEU A 343
PHE A 361
 None
ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
None
 1.39A 1xwfD-3h9uA:
56.4		 1xwfD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
ASP A 130
ASP A 189
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.97A 1xwfD-3h9uA:
56.4		 1xwfD-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
ASP A 189
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.82A 1xwfD-3h9uA:
56.4		 1xwfD-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 10 THR A 274
LEU A 191
GLY A 226
VAL A 240
VAL A 217
 None
 1.24A 2cp4A-3h9uA:
undetectable		 2cp4A-3h9uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 6 LEU A  51
SER A 182
ASP A 396
GLU A 155
 None
 0.92A 2vn1B-3h9uA:
undetectable		 2vn1B-3h9uA:
15.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.51A 2zj0A-3h9uA:
55.5		 2zj0A-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.58A 2zj0A-3h9uA:
55.5		 2zj0A-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.47A 2zj0B-3h9uA:
55.6		 2zj0B-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.60A 2zj0B-3h9uA:
55.6		 2zj0B-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 LEU A  51
GLN A  56
THR A  57
THR A 156
HIS A 300
 None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
 0.51A 2zj0B-3h9uA:
55.6		 2zj0B-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
HIS A 352
 None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 ( 3.3A)
 1.41A 2zj0C-3h9uA:
55.6		 2zj0C-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.55A 2zj0C-3h9uA:
55.6		 2zj0C-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 LEU A  51
GLN A  56
THR A  57
THR A 156
HIS A 300
 None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
 0.40A 2zj0C-3h9uA:
55.6		 2zj0C-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 2zj0D-3h9uA:
55.5		 2zj0D-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.50A 2zj0D-3h9uA:
55.5		 2zj0D-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.34A 2zj0D-3h9uA:
55.5		 2zj0D-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 LEU A  51
GLN A  56
THR A  57
THR A 156
 None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
 0.42A 2zj0D-3h9uA:
55.5		 2zj0D-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.53A 3ce6A-3h9uA:
55.8		 3ce6A-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.54A 3ce6A-3h9uA:
55.8		 3ce6A-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
 None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.14A 3ce6B-3h9uA:
55.9		 3ce6B-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.58A 3ce6B-3h9uA:
55.9		 3ce6B-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 LEU A  51
GLN A  56
THR A  57
THR A 156
HIS A 300
 None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
 0.35A 3ce6B-3h9uA:
55.9		 3ce6B-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.51A 3ce6C-3h9uA:
56.1		 3ce6C-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.56A 3ce6C-3h9uA:
56.1		 3ce6C-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.54A 3ce6D-3h9uA:
56.0		 3ce6D-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.37A 3ce6D-3h9uA:
56.0		 3ce6D-3h9uA:
56.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 LEU A  51
GLN A  56
THR A  57
HIS A 300
LEU A 343
 None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-4.0A)
 0.49A 3ce6D-3h9uA:
56.0		 3ce6D-3h9uA:
56.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 ALA A 268
ALA A 215
VAL A 344
ILE A 298
CYH A 227
 None
None
None
NAD  A 438 (-4.4A)
None
 1.09A 3e00A-3h9uA:
undetectable		 3e00A-3h9uA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 ILE A 369
LEU A 402
GLU A  35
GLU A  66
SER A 358
 None
 1.20A 3eigA-3h9uA:
undetectable		 3eigA-3h9uA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 PRO A 353
VAL A 356
THR A 274
GLY A 224
 None
 0.93A 3elzB-3h9uA:
undetectable		 3elzB-3h9uA:
16.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		10 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
ASN A 190
LEU A 343
LEU A 346
GLY A 351
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
None
 0.73A 3g1uA-3h9uA:
62.4		 3g1uA-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.55A 3g1uA-3h9uA:
62.4		 3g1uA-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
 0.32A 3g1uA-3h9uA:
62.4		 3g1uA-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
GLN A  56
ASP A 130
THR A 156
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.37A 3g1uB-3h9uA:
62.6		 3g1uB-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 THR A  57
GLU A 155
HIS A 300
 ADN  A 439 (-4.7A)
None
None
 0.18A 3g1uB-3h9uA:
62.6		 3g1uB-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
 1.35A 3g1uC-3h9uA:
63.4		 3g1uC-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 LEU A  51
ASP A 130
GLU A 155
LYS A 185
LEU A 346
 None
None
None
NAD  A 438 ( 3.9A)
ADN  A 439 ( 4.7A)
 0.97A 3g1uC-3h9uA:
63.4		 3g1uC-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.7A)
None
 0.40A 3g1uC-3h9uA:
63.4		 3g1uC-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
HIS A 352
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 3.3A)
 0.35A 3g1uC-3h9uA:
63.4		 3g1uC-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 LEU A  51
ASP A 130
THR A 156
ASP A 189
LEU A 346
 None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.22A 3g1uD-3h9uA:
63.2		 3g1uD-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
THR A 156
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.38A 3g1uD-3h9uA:
63.2		 3g1uD-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
GLU A 155
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
None
 0.20A 3g1uD-3h9uA:
63.2		 3g1uD-3h9uA:
85.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 LEU A  51
ASP A 130
LYS A 185
ASP A 189
LEU A 346
 None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.08A 3glqA-3h9uA:
58.4		 3glqA-3h9uA:
57.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.29A 3glqA-3h9uA:
58.4		 3glqA-3h9uA:
57.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
GLU A 155
THR A 156
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
 0.56A 3glqA-3h9uA:
58.4		 3glqA-3h9uA:
57.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.48A 3glqB-3h9uA:
58.4		 3glqB-3h9uA:
57.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.31A 3glqB-3h9uA:
58.4		 3glqB-3h9uA:
57.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
GLU A 155
THR A 156
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
 0.34A 3glqB-3h9uA:
58.4		 3glqB-3h9uA:
57.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 LEU A  51
ASP A 130
LYS A 185
ASP A 189
LEU A 346
 None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.01A 3n58A-3h9uA:
58.6		 3n58A-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.27A 3n58A-3h9uA:
58.6		 3n58A-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
GLU A 155
THR A 156
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
 0.30A 3n58A-3h9uA:
58.6		 3n58A-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
 None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.17A 3n58C-3h9uA:
58.6		 3n58C-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.49A 3n58C-3h9uA:
58.6		 3n58C-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.32A 3n58C-3h9uA:
58.6		 3n58C-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.40A 3n58C-3h9uA:
58.6		 3n58C-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 THR A  57
ASP A 130
THR A 156
ASP A 189
LEU A 346
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.41A 3n58C-3h9uA:
58.6		 3n58C-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 LEU A  51
GLN A  56
THR A  57
GLU A 155
HIS A 300
 None
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
None
 0.16A 3n58C-3h9uA:
58.6		 3n58C-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
 None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.16A 3n58D-3h9uA:
58.2		 3n58D-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.46A 3n58D-3h9uA:
58.2		 3n58D-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.43A 3n58D-3h9uA:
58.2		 3n58D-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 343
LEU A 346
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.30A 3n58D-3h9uA:
58.2		 3n58D-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 THR A  57
ASP A 130
THR A 156
ASP A 189
LEU A 346
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.44A 3n58D-3h9uA:
58.2		 3n58D-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
GLU A 155
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
None
 0.14A 3n58D-3h9uA:
58.2		 3n58D-3h9uA:
61.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.38A 3ondA-3h9uA:
60.2		 3ondA-3h9uA:
59.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.28A 3ondA-3h9uA:
60.2		 3ondA-3h9uA:
59.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.42A 3ondA-3h9uA:
60.2		 3ondA-3h9uA:
59.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 GLN A  56
THR A  57
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-4.0A)
 0.29A 3ondA-3h9uA:
60.2		 3ondA-3h9uA:
59.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.38A 3ondB-3h9uA:
55.7		 3ondB-3h9uA:
59.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.29A 3ondB-3h9uA:
55.7		 3ondB-3h9uA:
59.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.42A 3ondB-3h9uA:
55.7		 3ondB-3h9uA:
59.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 GLN A  56
THR A  57
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-4.0A)
 0.31A 3ondB-3h9uA:
55.7		 3ondB-3h9uA:
59.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 6 GLY A 159
THR A 158
GLU A 154
ASP A 133
 None
NAD  A 438 (-3.6A)
None
None
 0.91A 3ps9A-3h9uA:
5.3		 3ps9A-3h9uA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 7 THR A 156
ASN A 190
ASP A 130
HIS A  52
 NAD  A 438 (-3.8A)
NAD  A 438 (-3.4A)
None
ADN  A 439 ( 4.7A)
 1.10A 3t01A-3h9uA:
undetectable		 3t01A-3h9uA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 LYS A  40
PRO A  41
LEU A  42
 None
 0.79A 3tpxE-3h9uA:
undetectable		 3tpxE-3h9uA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 VAL A 272
LEU A 191
GLY A 226
ALA A 228
LEU A 231
 None
 1.12A 4coxA-3h9uA:
undetectable		 4coxA-3h9uA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 VAL A 272
LEU A 191
GLY A 226
ALA A 228
LEU A 231
 None
 1.11A 4coxB-3h9uA:
undetectable		 4coxB-3h9uA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 VAL A 272
LEU A 191
GLY A 226
ALA A 228
LEU A 231
 None
 1.11A 4coxD-3h9uA:
undetectable		 4coxD-3h9uA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 6 SER A 182
ASP A 181
SER A 186
GLU A 155
 None
 1.20A 4eysA-3h9uA:
2.7		 4eysA-3h9uA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.39A 4lvcA-3h9uA:
57.6		 4lvcA-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.20A 4lvcA-3h9uA:
57.6		 4lvcA-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.44A 4lvcA-3h9uA:
57.6		 4lvcA-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.31A 4lvcB-3h9uA:
57.6		 4lvcB-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
HIS A 300
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.19A 4lvcB-3h9uA:
57.6		 4lvcB-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
LEU A 343
LEU A 346
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
 0.42A 4lvcB-3h9uA:
57.6		 4lvcB-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.38A 4lvcC-3h9uA:
57.8		 4lvcC-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.15A 4lvcC-3h9uA:
57.8		 4lvcC-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.44A 4lvcC-3h9uA:
57.8		 4lvcC-3h9uA:
58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 VAL A  71
ALA A  45
PHE A 118
 None
 0.93A 4olbA-3h9uA:
undetectable		 4olbA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 VAL A  71
ALA A  48
PHE A 118
 None
 0.93A 4olbA-3h9uA:
undetectable		 4olbA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 PRO A  41
LEU A  67
GLN A 368
 None
 0.69A 4pevB-3h9uA:
5.1		 4pevB-3h9uA:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.45A 4pfjA-3h9uA:
64.2		 4pfjA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.23A 4pfjA-3h9uA:
64.2		 4pfjA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 7 THR A  57
THR A 156
HIS A 300
LEU A 343
ASN A 345
SER A 360
 ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-2.9A)
None
 0.53A 4pfjA-3h9uA:
64.2		 4pfjA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.61A 4pfjB-3h9uA:
62.9		 4pfjB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 6 THR A  57
GLN A  82
THR A 156
HIS A 300
ASN A 345
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
None
NAD  A 438 (-2.9A)
 0.39A 4pfjB-3h9uA:
62.9		 4pfjB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
ASN A 345
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
NAD  A 438 (-2.9A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.40A 4pgfA-3h9uA:
63.7		 4pgfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 6 THR A  54
THR A  57
THR A 156
HIS A 300
LEU A 346
 ADN  A 439 (-2.7A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 4.7A)
 0.35A 4pgfA-3h9uA:
63.7		 4pgfA-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.63A 4pgfB-3h9uA:
62.4		 4pgfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 THR A  54
THR A  57
THR A 156
HIS A 300
ASN A 345
 ADN  A 439 (-2.7A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-2.9A)
 0.40A 4pgfB-3h9uA:
62.4		 4pgfB-3h9uA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A 156
THR A 157
THR A 273
ASN A 345
 NAD  A 438 (-3.8A)
NAD  A 438 (-3.2A)
None
NAD  A 438 (-2.9A)
 1.40A 4pgfB-3h9uA:
62.4		 4pgfB-3h9uA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 7 GLU A 106
GLU A 102
TYR A 107
GLU A 104
 None
 1.23A 4r87I-3h9uA:
undetectable		 4r87I-3h9uA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 VAL A  71
ALA A  45
PHE A 118
 None
 0.91A 4w5nA-3h9uA:
undetectable		 4w5nA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 VAL A  71
ALA A  48
PHE A 118
 None
 0.88A 4w5nA-3h9uA:
undetectable		 4w5nA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 7 ILE A 298
LEU A 198
GLY A 226
LYS A 225
 NAD  A 438 (-4.4A)
None
None
None
 1.03A 4z69A-3h9uA:
undetectable		 4z69A-3h9uA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 5axaA-3h9uA:
63.5		 5axaA-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.18A 5axaA-3h9uA:
63.5		 5axaA-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.41A 5axaC-3h9uA:
63.3		 5axaC-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.17A 5axaC-3h9uA:
63.3		 5axaC-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.28A 5axdA-3h9uA:
63.4		 5axdA-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
 0.30A 5axdA-3h9uA:
63.4		 5axdA-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.42A 5axdA-3h9uA:
63.4		 5axdA-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.38A 5axdC-3h9uA:
63.4		 5axdC-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
 0.28A 5axdC-3h9uA:
63.4		 5axdC-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.42A 5axdC-3h9uA:
63.4		 5axdC-3h9uA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.43A 5hm8A-3h9uA:
52.9		 5hm8A-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.32A 5hm8A-3h9uA:
52.9		 5hm8A-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.24A 5hm8A-3h9uA:
52.9		 5hm8A-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.48A 5hm8A-3h9uA:
52.9		 5hm8A-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.44A 5hm8B-3h9uA:
52.9		 5hm8B-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.32A 5hm8B-3h9uA:
52.9		 5hm8B-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.23A 5hm8B-3h9uA:
52.9		 5hm8B-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.48A 5hm8B-3h9uA:
52.9		 5hm8B-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.43A 5hm8C-3h9uA:
53.5		 5hm8C-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.31A 5hm8C-3h9uA:
53.5		 5hm8C-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.23A 5hm8C-3h9uA:
53.5		 5hm8C-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.48A 5hm8C-3h9uA:
53.5		 5hm8C-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.43A 5hm8D-3h9uA:
53.1		 5hm8D-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.31A 5hm8D-3h9uA:
53.1		 5hm8D-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.24A 5hm8D-3h9uA:
53.1		 5hm8D-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.48A 5hm8D-3h9uA:
53.1		 5hm8D-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.43A 5hm8E-3h9uA:
53.5		 5hm8E-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.32A 5hm8E-3h9uA:
53.5		 5hm8E-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.24A 5hm8E-3h9uA:
53.5		 5hm8E-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.48A 5hm8E-3h9uA:
53.5		 5hm8E-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.43A 5hm8F-3h9uA:
53.0		 5hm8F-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.32A 5hm8F-3h9uA:
53.0		 5hm8F-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.24A 5hm8F-3h9uA:
53.0		 5hm8F-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.47A 5hm8F-3h9uA:
53.0		 5hm8F-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.43A 5hm8G-3h9uA:
52.9		 5hm8G-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.32A 5hm8G-3h9uA:
52.9		 5hm8G-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.24A 5hm8G-3h9uA:
52.9		 5hm8G-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.68A 5hm8G-3h9uA:
52.9		 5hm8G-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.44A 5hm8H-3h9uA:
53.5		 5hm8H-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.32A 5hm8H-3h9uA:
53.5		 5hm8H-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.25A 5hm8H-3h9uA:
53.5		 5hm8H-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.48A 5hm8H-3h9uA:
53.5		 5hm8H-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.37A 5m5kA-3h9uA:
57.1		 5m5kA-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.20A 5m5kA-3h9uA:
57.1		 5m5kA-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.46A 5m5kA-3h9uA:
57.1		 5m5kA-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.38A 5m5kB-3h9uA:
57.3		 5m5kB-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
THR A 156
LYS A 185
ASP A 189
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.32A 5m5kB-3h9uA:
57.3		 5m5kB-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
LEU A 343
LEU A 346
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
 0.27A 5m5kB-3h9uA:
57.3		 5m5kB-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.40A 5m5kC-3h9uA:
57.0		 5m5kC-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.21A 5m5kC-3h9uA:
57.0		 5m5kC-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.44A 5m5kC-3h9uA:
57.0		 5m5kC-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.49A 5m66A-3h9uA:
57.4		 5m66A-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.39A 5m66A-3h9uA:
57.4		 5m66A-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.27A 5m66A-3h9uA:
57.4		 5m66A-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
GLU A 155
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-4.0A)
 0.30A 5m66A-3h9uA:
57.4		 5m66A-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.37A 5m66B-3h9uA:
57.2		 5m66B-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.22A 5m66B-3h9uA:
57.2		 5m66B-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.39A 5m66B-3h9uA:
57.2		 5m66B-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
GLN A  56
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.27A 5m66C-3h9uA:
57.1		 5m66C-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.41A 5m66C-3h9uA:
57.1		 5m66C-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.40A 5m66D-3h9uA:
57.4		 5m66D-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
GLN A  56
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.21A 5m66D-3h9uA:
57.4		 5m66D-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 THR A  57
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.50A 5m66D-3h9uA:
57.4		 5m66D-3h9uA:
58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.44A 5utuF-3h9uA:
56.1		 5utuF-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.37A 5utuF-3h9uA:
56.1		 5utuF-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 THR A 157
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 NAD  A 438 (-3.2A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.26A 5utuF-3h9uA:
56.1		 5utuF-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.45A 5utuH-3h9uA:
53.5		 5utuH-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.17A 5utuH-3h9uA:
53.5		 5utuH-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 THR A  57
GLU A 155
THR A 156
LEU A 343
 ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.58A 5utuH-3h9uA:
53.5		 5utuH-3h9uA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.39A 5v96A-3h9uA:
56.9		 5v96A-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.19A 5v96A-3h9uA:
56.9		 5v96A-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.40A 5v96B-3h9uA:
57.1		 5v96B-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.18A 5v96B-3h9uA:
57.1		 5v96B-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.40A 5v96C-3h9uA:
57.2		 5v96C-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.18A 5v96C-3h9uA:
57.2		 5v96C-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.38A 5v96D-3h9uA:
57.2		 5v96D-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.19A 5v96D-3h9uA:
57.2		 5v96D-3h9uA:
55.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 LEU A  51
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
 None
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 0.97A 6aphA-3h9uA:
62.8		 6aphA-3h9uA:
66.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.34A 6aphA-3h9uA:
62.8		 6aphA-3h9uA:
66.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 346
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 4.7A)
 0.32A 6aphA-3h9uA:
62.8		 6aphA-3h9uA:
66.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 HIS A  52
THR A  54
GLN A  56
THR A  57
ASP A 189
ASN A 345
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-2.9A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.29A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
ADN  A 439 ( 4.7A)
None
 1.05A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 10 GLY A 219
GLY A 221
GLU A 242
VAL A 243
ASP A 244
THR A 275
ASN A 277
ILE A 280
 NAD  A 438 ( 3.7A)
NAD  A 438 (-3.3A)
NAD  A 438 (-2.9A)
NAD  A 438 (-4.2A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-4.1A)
NAD  A 438 (-4.6A)
 0.17A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 10 GLY A 219
GLY A 224
THR A 275
ASN A 277
ILE A 280
 NAD  A 438 ( 3.7A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-4.1A)
NAD  A 438 (-4.6A)
 1.24A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 LEU A 414
GLN A 418
LYS A 431
 None
 0.40A 6exiB-3h9uA:
55.1		 6exiB-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
ADN  A 439 ( 4.7A)
None
 1.05A 6exiB-3h9uA:
55.1		 6exiB-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 HIS A  52
THR A  54
GLN A  56
THR A  57
LYS A 185
ASP A 189
ASN A 345
LEU A 346
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-2.9A)
ADN  A 439 ( 4.7A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.70A 6exiB-3h9uA:
55.1		 6exiB-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 LEU A 414
GLN A 418
LYS A 431
 None
 0.43A 6exiA-3h9uA:
56.3		 6exiA-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 10 GLY A 219
GLY A 221
GLU A 242
VAL A 243
ASP A 244
THR A 275
ASN A 277
ILE A 280
 NAD  A 438 ( 3.7A)
NAD  A 438 (-3.3A)
NAD  A 438 (-2.9A)
NAD  A 438 (-4.2A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-4.1A)
NAD  A 438 (-4.6A)
 0.18A 6exiB-3h9uA:
55.1		 6exiB-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 10 GLY A 219
GLY A 224
THR A 275
ASN A 277
ILE A 280
 NAD  A 438 ( 3.7A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-4.1A)
NAD  A 438 (-4.6A)
 1.24A 6exiB-3h9uA:
55.1		 6exiB-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		10 / 12 LEU A  51
HIS A  52
THR A  54
GLN A  56
THR A  57
ASP A 189
ASN A 345
LEU A 346
HIS A 352
MET A 357
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-2.9A)
ADN  A 439 ( 4.7A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
 0.30A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 LEU A  51
HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
ADN  A 439 ( 4.7A)
 1.02A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 LEU A  51
THR A  54
GLN A  56
THR A  57
ASP A 189
ASN A 190
MET A 357
 None
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-3.4A)
ADN  A 439 ( 3.7A)
 0.83A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		3 / 3 LEU A 343
GLY A 351
PHE A 361
 NAD  A 438 (-4.0A)
ADN  A 439 (-3.5A)
None
 0.34A 6exiC-3h9uA:
56.4		 6exiC-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 GLY A 219
GLY A 221
GLU A 242
VAL A 243
ASP A 244
THR A 275
ASN A 277
ILE A 280
 NAD  A 438 ( 3.7A)
NAD  A 438 (-3.3A)
NAD  A 438 (-2.9A)
NAD  A 438 (-4.2A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-4.1A)
NAD  A 438 (-4.6A)
 0.18A 6exiC-3h9uA:
56.4
6exiD-3h9uA:
55.8		 6exiC-3h9uA:
13.65
6exiD-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		11 / 12 HIS A  52
THR A  54
GLN A  56
THR A  57
ASP A 189
ASN A 345
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-2.9A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.36A 6exiD-3h9uA:
55.8		 6exiD-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 HIS A  52
THR A  54
GLN A  56
THR A  57
HIS A 300
LEU A 346
GLY A 351
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
None
 1.08A 6exiD-3h9uA:
55.8		 6exiD-3h9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		8 / 12 GLY A 219
GLY A 221
GLU A 242
VAL A 243
ASP A 244
THR A 275
ASN A 277
ILE A 280
 NAD  A 438 ( 3.7A)
NAD  A 438 (-3.3A)
NAD  A 438 (-2.9A)
NAD  A 438 (-4.2A)
None
NAD  A 438 (-4.0A)
NAD  A 438 (-4.1A)
NAD  A 438 (-4.6A)
 0.18A 6exiC-3h9uA:
56.4
6exiD-3h9uA:
55.8		 6exiC-3h9uA:
13.65
6exiD-3h9uA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 ( 3.3A)
 1.37A 6f3mA-3h9uA:
56.8		 6f3mA-3h9uA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
HIS A 300
LEU A 343
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
NAD  A 438 (-4.0A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.25A 6f3mA-3h9uA:
56.8		 6f3mA-3h9uA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.32A 6f3mA-3h9uA:
56.8		 6f3mA-3h9uA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.42A 6f3mA-3h9uA:
56.8		 6f3mA-3h9uA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
LEU A 346
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
ADN  A 439 ( 4.7A)
 0.31A 6f3mA-3h9uA:
56.8		 6f3mA-3h9uA:
56.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.41A 6f3mB-3h9uA:
56.8		 6f3mB-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.20A 6f3mB-3h9uA:
56.8		 6f3mB-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.31A 6f3mB-3h9uA:
56.8		 6f3mB-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.40A 6f3mB-3h9uA:
56.8		 6f3mB-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.26A 6f3mC-3h9uA:
56.8		 6f3mC-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
HIS A 300
LEU A 343
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
NAD  A 438 (-4.0A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.25A 6f3mC-3h9uA:
56.8		 6f3mC-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.30A 6f3mC-3h9uA:
56.8		 6f3mC-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.42A 6f3mC-3h9uA:
56.8		 6f3mC-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
LEU A 346
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
ADN  A 439 ( 4.7A)
 0.31A 6f3mC-3h9uA:
56.8		 6f3mC-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.41A 6f3mD-3h9uA:
56.9		 6f3mD-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
HIS A 300
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
None
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.19A 6f3mD-3h9uA:
56.9		 6f3mD-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
HIS A 300
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
None
 1.31A 6f3mD-3h9uA:
56.9		 6f3mD-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 5 GLN A  56
THR A  57
THR A 156
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
NAD  A 438 (-4.0A)
 0.40A 6f3mD-3h9uA:
56.9		 6f3mD-3h9uA:
56.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 6f3nA-3h9uA:
56.9		 6f3nA-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.30A 6f3nA-3h9uA:
56.9		 6f3nA-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
 0.36A 6f3nA-3h9uA:
56.9		 6f3nA-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 6f3nB-3h9uA:
56.8		 6f3nB-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
THR A 156
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.28A 6f3nB-3h9uA:
56.8		 6f3nB-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
THR A 156
ASP A 189
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-3.8A)
NAD  A 438 ( 4.4A)
 1.39A 6f3nB-3h9uA:
56.8		 6f3nB-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
None
NAD  A 438 (-4.0A)
 0.32A 6f3nB-3h9uA:
56.8		 6f3nB-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.20A 6f3nC-3h9uA:
56.8		 6f3nC-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 12 HIS A  52
THR A  57
ASP A 130
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
ADN  A 439 (-4.7A)
None
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.41A 6f3nC-3h9uA:
56.8		 6f3nC-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
 0.36A 6f3nC-3h9uA:
56.8		 6f3nC-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 6f3nD-3h9uA:
56.9		 6f3nD-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.30A 6f3nD-3h9uA:
56.9		 6f3nD-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		4 / 4 GLN A  56
THR A  57
THR A 156
HIS A 300
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
 0.36A 6f3nD-3h9uA:
56.9		 6f3nD-3h9uA:
55.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.42A 6gbnA-3h9uA:
62.1		 6gbnA-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.20A 6gbnA-3h9uA:
62.1		 6gbnA-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.46A 6gbnA-3h9uA:
62.1		 6gbnA-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		6 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
 1.33A 6gbnB-3h9uA:
61.5		 6gbnB-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.20A 6gbnB-3h9uA:
61.5		 6gbnB-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 346
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
ADN  A 439 ( 4.7A)
 0.33A 6gbnB-3h9uA:
61.5		 6gbnB-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.44A 6gbnC-3h9uA:
62.1		 6gbnC-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
LEU A 346
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 4.7A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.18A 6gbnC-3h9uA:
62.1		 6gbnC-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
GLY A 351
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
ADN  A 439 (-3.5A)
 0.34A 6gbnC-3h9uA:
62.1		 6gbnC-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		7 / 12 HIS A  52
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 343
HIS A 352
 ADN  A 439 ( 4.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
NAD  A 438 (-4.0A)
ADN  A 439 ( 3.3A)
 1.41A 6gbnD-3h9uA:
61.4		 6gbnD-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		12 / 12 LEU A  51
HIS A  52
THR A  54
ASP A 130
GLU A 155
LYS A 185
ASP A 189
LEU A 346
GLY A 351
HIS A 352
MET A 357
PHE A 361
 None
ADN  A 439 ( 4.7A)
ADN  A 439 (-2.7A)
None
None
NAD  A 438 ( 3.9A)
NAD  A 438 ( 4.4A)
ADN  A 439 ( 4.7A)
ADN  A 439 (-3.5A)
ADN  A 439 ( 3.3A)
ADN  A 439 ( 3.7A)
None
 0.20A 6gbnD-3h9uA:
61.4		 6gbnD-3h9uA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_2
(-)		 3h9u ADENOSYLHOMOCYSTEINA
SE
(Trypanosoma
brucei) 		5 / 5 GLN A  56
THR A  57
THR A 156
HIS A 300
LEU A 343
 ADN  A 439 (-3.6A)
ADN  A 439 (-4.7A)
NAD  A 438 (-3.8A)
None
NAD  A 438 (-4.0A)
 0.44A 6gbnD-3h9uA:
61.4		 6gbnD-3h9uA:
65.92