SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ha4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3ha4 MIX1
(Leishmania
major) 		4 / 5 LEU A 143
ALA A 173
ILE A 170
SER A 171
 None
 1.16A 2othA-3ha4A:
undetectable		 2othA-3ha4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 3ha4 MIX1
(Leishmania
major) 		4 / 6 LEU A  78
LEU A  77
TRP A  75
ILE A 112
 None
 0.99A 2rlfA-3ha4A:
undetectable
2rlfB-3ha4A:
undetectable		 2rlfA-3ha4A:
14.60
2rlfB-3ha4A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3ha4 MIX1
(Leishmania
major) 		4 / 5 TYR A 106
THR A 102
ARG A  81
LEU A  77
 None
 1.39A 3qelC-3ha4A:
undetectable		 3qelC-3ha4A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3ha4 MIX1
(Leishmania
major) 		4 / 8 ILE A 170
ASN A 148
THR A 117
PRO A 113
 None
 1.00A 5x23A-3ha4A:
undetectable		 5x23A-3ha4A:
14.53