SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ham'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 6 LEU A 188
VAL A 216
VAL A 129
ASP A 126
 None
 1.15A 1dz4A-3hamA:
undetectable		 1dz4A-3hamA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 6 LEU A 188
VAL A 216
VAL A 129
ASP A 126
 None
 1.16A 1dz4B-3hamA:
undetectable		 1dz4B-3hamA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		3 / 3 ASP A  28
LYS A 277
ARG A 279
 None
 1.14A 1ra8A-3hamA:
undetectable		 1ra8A-3hamA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 11 GLY A 212
PHE A 214
PHE A 116
LEU A 188
VAL A 208
 None
 1.11A 1ukbA-3hamA:
undetectable		 1ukbA-3hamA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 7 ILE A 283
ILE A 271
LEU A 150
ILE A 153
 None
 0.71A 2q83A-3hamA:
14.6		 2q83A-3hamA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 7 GLN A  15
ILE A  18
TYR A  39
CYH A  35
 None
 1.28A 2xz5D-3hamA:
undetectable
2xz5E-3hamA:
undetectable		 2xz5D-3hamA:
20.33
2xz5E-3hamA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 6 LEU A 188
VAL A 216
VAL A 129
ASP A 126
 None
 1.12A 2zawA-3hamA:
undetectable		 2zawA-3hamA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 4 ILE A 199
THR A  32
LYS A  42
TYR A  87
 None
 1.30A 3elzC-3hamA:
0.4		 3elzC-3hamA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		3 / 3 ARG A  50
GLU A  56
ASP A 192
 None
None
LLL  A 500 (-2.8A)
 0.81A 3g2oA-3hamA:
undetectable		 3g2oA-3hamA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
ASP A 213
CYH A 225
TRP A 265
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
 0.99A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
SER A 194
ASP A 213
CYH A 225
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
 0.86A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
SER A 194
CYH A 225
ASP A 232
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.3A)
 0.91A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 213
CYH A 225
TRP A 265
TYR A 272
 LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.21A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 SER A 194
ASP A 213
CYH A 225
TYR A 272
 LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 ( 4.7A)
 1.13A 3havA-3hamA:
39.0		 3havA-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_B_SRYB403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		6 / 9 ASP A 192
SER A 194
ASN A 261
ASP A 262
TRP A 265
ASP A 268
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
None
 0.95A 3havB-3hamA:
37.9		 3havB-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_B_SRYB403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		7 / 9 ASP A 192
SER A 194
ASP A 213
CYH A 225
ASN A 261
TRP A 265
ASP A 268
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.8A)
None
 0.82A 3havB-3hamA:
37.9		 3havB-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_B_SRYB403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 9 ASP A 213
ASN A 261
ASP A 262
TRP A 265
ASP A 268
 LLL  A 500 (-3.5A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
None
 1.37A 3havB-3hamA:
37.9		 3havB-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		10 / 12 ASN A 191
ASP A 192
SER A 194
ASN A 196
CYH A 225
SER A 230
ASP A 232
ASN A 261
ASP A 262
TRP A 265
 GOL  A 301 (-4.9A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
 0.70A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		6 / 12 ASN A 197
CYH A 225
ASN A 261
ASP A 262
TRP A 265
TYR A 272
 None
GOL  A 301 (-3.4A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.14A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASN A 221
ASN A 197
CYH A 225
TRP A 265
TYR A 272
 None
None
GOL  A 301 (-3.4A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.33A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		7 / 12 ASN A 221
SER A 194
CYH A 225
SER A 230
ASP A 232
TRP A 265
TYR A 272
 None
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.37A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		10 / 12 ASP A 192
SER A 194
ASN A 196
CYH A 225
SER A 230
ASP A 232
ASN A 261
ASP A 262
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 0.79A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		7 / 12 ASP A 213
CYH A 225
SER A 230
ASN A 261
ASP A 262
TRP A 265
TYR A 272
 LLL  A 500 (-3.5A)
GOL  A 301 (-3.4A)
LLL  A 500 (-2.8A)
GOL  A 301 (-3.3A)
LLL  A 500 (-3.7A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.06A 3havC-3hamA:
37.4		 3havC-3hamA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 PHE A 234
ILE A 199
PHE A 206
ALA A 195
ILE A 209
 None
 1.29A 3ndiA-3hamA:
undetectable		 3ndiA-3hamA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG8_A_TOYA305_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.49A 3sg8A-3hamA:
32.7		 3sg8A-3hamA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG8_B_TOYB305_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.49A 3sg8B-3hamA:
32.4		 3sg8B-3hamA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG9_A_KANA304_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 10 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.32A 3sg9A-3hamA:
32.7		 3sg9A-3hamA:
34.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 ASP A 192
SER A 194
ASP A 213
TRP A 265
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
 0.88A 3sg9B-3hamA:
20.9		 3sg9B-3hamA:
34.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFB_A_KANA401_1
(APH(2')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 9 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 0.98A 4dfbA-3hamA:
21.0		 4dfbA-3hamA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFU_A_KANA401_1
(APH(2')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.37A 4dfuA-3hamA:
32.8		 4dfuA-3hamA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DFU_B_KANB402_1
(APH(2')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 12 ASP A 192
SER A 194
ASP A 213
TRP A 265
TYR A 272
 LLL  A 500 (-2.8A)
LLL  A 500 (-3.3A)
LLL  A 500 (-3.5A)
LLL  A 500 (-3.8A)
LLL  A 500 ( 4.7A)
 1.44A 4dfuB-3hamA:
32.9		 4dfuB-3hamA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 11 LYS A  42
PRO A  73
ILE A  88
ILE A 209
ASP A 210
 None
 0.76A 4dt8A-3hamA:
21.4		 4dt8A-3hamA:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 10 LYS A  42
PRO A  73
ILE A  88
ILE A 209
ASP A 210
 None
 0.43A 4dt8B-3hamA:
32.6		 4dt8B-3hamA:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		5 / 10 LYS A  42
PRO A  73
ILE A  88
ILE A 209
ASP A 210
 None
 0.74A 4dtaA-3hamA:
21.3		 4dtaA-3hamA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 PRO A  73
ILE A  88
ILE A 209
ASP A 210
 None
 0.47A 4dtaB-3hamA:
21.4		 4dtaB-3hamA:
34.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		3 / 3 PHE A 223
VAL A 242
GLU A 113
 None
 0.70A 4fvqA-3hamA:
8.6		 4fvqA-3hamA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 6 LEU A 188
VAL A 216
VAL A 129
ASP A 126
 None
 1.16A 4kkyX-3hamA:
undetectable		 4kkyX-3hamA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		3 / 3 ASN A 196
ASP A 233
ASP A 222
 LLL  A 500 (-3.3A)
None
None
 0.88A 4obwD-3hamA:
undetectable		 4obwD-3hamA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		3 / 3 THR A 170
ALA A 294
ASN A 174
 None
 0.57A 5ersA-3hamA:
undetectable		 5ersA-3hamA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		4 / 8 TYR A  95
THR A  94
ARG A  92
GLN A  97
 None
 1.41A 5tzoA-3hamA:
undetectable		 5tzoA-3hamA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Enterococcus
faecium) 		6 / 12 VAL A 208
PHE A 116
ILE A  72
ASN A 191
LEU A 120
HIS A 121
 None
None
None
GOL  A 301 (-4.9A)
None
None
 1.26A 5uvmB-3hamA:
undetectable		 5uvmB-3hamA:
17.55