SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		5 / 12 PHE A 350
LEU A 345
TYR A 348
LEU A 325
ASP A 324
 None
 1.35A 1e7wA-3hb0A:
2.7		 1e7wA-3hb0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		5 / 9 THR A 447
LEU A 275
VAL A 458
ILE A 312
ILE A 452
 BEF  A 801 (-3.7A)
BEF  A 801 (-4.2A)
None
None
None
 1.37A 1gebA-3hb0A:
undetectable		 1gebA-3hb0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		5 / 12 VAL A 336
ASP A 339
ASP A 329
PHE A 355
GLY A 373
 None
 1.23A 1ia0B-3hb0A:
3.4		 1ia0B-3hb0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		3 / 3 ASP A 525
THR A 278
GLU A 506
 None
None
MG  A 701 (-3.8A)
 0.87A 1pj7A-3hb0A:
undetectable		 1pj7A-3hb0A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		5 / 12 VAL A 336
ASP A 339
ASP A 329
PHE A 355
GLY A 373
 None
 1.23A 1tubB-3hb0A:
3.6		 1tubB-3hb0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		4 / 4 LEU A 463
SER A 428
LEU A 445
LEU A 275
 None
None
None
BEF  A 801 (-4.2A)
 1.14A 1yajA-3hb0A:
undetectable		 1yajA-3hb0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		5 / 12 ILE A 280
LEU A 425
ASN A 396
THR A 449
LEU A 445
 None
 1.04A 3a50D-3hb0A:
undetectable		 3a50D-3hb0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		5 / 12 ILE A 280
LEU A 425
ASN A 396
THR A 449
LEU A 445
 None
 1.08A 3a51C-3hb0A:
undetectable		 3a51C-3hb0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		3 / 3 GLN A 450
THR A 449
LEU A 315
 None
 0.55A 3ondA-3hb0A:
undetectable		 3ondA-3hb0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		3 / 3 GLN A 450
THR A 449
LEU A 315
 None
 0.55A 3ondB-3hb0A:
2.5		 3ondB-3hb0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)
(Homo
sapiens) 		5 / 10 ILE A 520
VAL A 466
ILE A 280
LEU A 463
PRO A 468
 None
 1.17A 5ienB-3hb0A:
undetectable		 5ienB-3hb0A:
21.14