SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		5 / 12 LEU A 147
GLY A 123
CYH A  24
ALA A 152
HIS A 159
 None
 0.90A 2bm9F-3hb7A:
2.8		 2bm9F-3hb7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		4 / 8 SER A 132
ALA A 103
PHE A 102
LEU A 111
 NA  A 202 (-3.6A)
None
None
None
 0.92A 2bxmA-3hb7A:
undetectable		 2bxmA-3hb7A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		4 / 4 LEU A 147
THR A 146
ILE A  49
HIS A   4
 None
 1.32A 2jfaB-3hb7A:
undetectable		 2jfaB-3hb7A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		4 / 7 GLN A  55
ARG A  68
LEU A  12
ASP A  14
 None
 0.92A 2qqcB-3hb7A:
undetectable
2qqcC-3hb7A:
undetectable		 2qqcB-3hb7A:
24.32
2qqcC-3hb7A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		4 / 7 LEU A  12
ASP A  14
GLN A  55
ARG A  68
 None
 0.91A 2qqcA-3hb7A:
undetectable
2qqcF-3hb7A:
undetectable		 2qqcA-3hb7A:
12.18
2qqcF-3hb7A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		4 / 7 GLN A  55
ARG A  68
LEU A  12
ASP A  14
 None
 0.92A 2qqcD-3hb7A:
undetectable
2qqcE-3hb7A:
undetectable		 2qqcD-3hb7A:
24.32
2qqcE-3hb7A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		4 / 7 LEU A  12
ASP A  14
GLN A  55
ARG A  68
 None
 0.87A 2qqcG-3hb7A:
undetectable
2qqcJ-3hb7A:
undetectable		 2qqcG-3hb7A:
12.18
2qqcJ-3hb7A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		4 / 7 LEU A  12
ASP A  14
GLN A  55
ARG A  68
 None
 0.91A 2qqcI-3hb7A:
undetectable
2qqcL-3hb7A:
undetectable		 2qqcI-3hb7A:
12.18
2qqcL-3hb7A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		3 / 3 THR A 135
SER A 132
ARG A 131
 NA  A 202 (-3.2A)
NA  A 202 (-3.6A)
NA  A 202 ( 4.9A)
 0.83A 3phnA-3hb7A:
undetectable		 3phnA-3hb7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		6 / 12 ASP A  10
PHE A  15
LEU A  22
HIS A  58
LYS A  96
CYH A 129
 None
None
None
NH4  A 201 (-4.1A)
None
None
 1.38A 3r2jC-3hb7A:
22.5		 3r2jC-3hb7A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		5 / 11 ASP A  10
PHE A  15
LEU A  22
LYS A  96
CYH A 129
 None
 1.22A 3r2jD-3hb7A:
22.2		 3r2jD-3hb7A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3hb7 ISOCHORISMATASE
HYDROLASE
(Alkaliphilus
metalliredigens) 		5 / 12 GLY A  27
GLY A  26
ASP A  10
MET A  11
ILE A  30
 None
 1.10A 4pghD-3hb7A:
undetectable		 4pghD-3hb7A:
18.43