SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3hba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 6 TYR A 306
VAL A 258
ILE A 260
LEU A 185
 None
 1.04A 1j96A-3hbaA:
undetectable		 1j96A-3hbaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 7 TYR A 306
VAL A 258
ILE A 260
LEU A 185
 None
 1.06A 1j96B-3hbaA:
undetectable		 1j96B-3hbaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 12 GLY A 210
ILE A 221
ILE A 255
LEU A 256
HIS A 286
 None
 1.10A 1kyvA-3hbaA:
2.2
1kyvE-3hbaA:
2.5		 1kyvA-3hbaA:
19.40
1kyvE-3hbaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 12 ILE A 255
LEU A 256
HIS A 286
GLY A 210
ILE A 221
 None
 1.11A 1kyvB-3hbaA:
2.5
1kyvC-3hbaA:
undetectable		 1kyvB-3hbaA:
19.40
1kyvC-3hbaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 12 ILE A 255
LEU A 256
HIS A 286
GLY A 210
ILE A 221
 None
 1.13A 1kyvC-3hbaA:
undetectable
1kyvD-3hbaA:
2.2		 1kyvC-3hbaA:
19.40
1kyvD-3hbaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 12 ILE A 255
LEU A 256
HIS A 286
GLY A 210
ILE A 221
 None
 1.14A 1kyvD-3hbaA:
2.5
1kyvE-3hbaA:
2.5		 1kyvD-3hbaA:
19.40
1kyvE-3hbaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 4 LEU A 122
VAL A 120
CYH A 119
ALA A 117
 None
 1.15A 1mz9E-3hbaA:
undetectable		 1mz9E-3hbaA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 11 LEU A 299
LEU A 185
ILE A 296
ALA A 187
ASP A 291
 None
 1.18A 2q72A-3hbaA:
undetectable		 2q72A-3hbaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 11 LEU A 299
LEU A 185
ILE A 296
ALA A 187
ASP A 291
 None
 1.14A 2qjuA-3hbaA:
undetectable		 2qjuA-3hbaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 12 SER A 159
PHE A  63
ILE A  94
LEU A  23
GLU A  30
 None
 1.20A 3aocC-3hbaA:
undetectable		 3aocC-3hbaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 12 LEU A 299
LEU A 185
ILE A 296
ALA A 187
ASP A 291
 None
 1.06A 3gwwA-3hbaA:
undetectable		 3gwwA-3hbaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 10 ALA A 109
ILE A 130
ILE A 138
PRO A 139
ILE A  94
 None
 1.11A 3hbbA-3hbaA:
undetectable		 3hbbA-3hbaA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 8 ALA A  59
PHE A  63
LEU A 158
ALA A 165
 None
 0.69A 3hrdA-3hbaA:
undetectable
3hrdB-3hbaA:
2.8		 3hrdA-3hbaA:
22.67
3hrdB-3hbaA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 8 ILE A  96
PHE A  63
LEU A 158
ALA A 165
 None
 0.80A 3hrdA-3hbaA:
undetectable
3hrdB-3hbaA:
2.8		 3hrdA-3hbaA:
22.67
3hrdB-3hbaA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		3 / 3 GLU A 227
LEU A 223
LEU A 256
 None
 0.77A 3ohtB-3hbaA:
undetectable		 3ohtB-3hbaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		3 / 3 GLN A 287
THR A 288
LEU A 181
 None
 0.72A 3ondA-3hbaA:
3.1		 3ondA-3hbaA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 5 SER A 102
ILE A 133
GLY A 100
PRO A 129
 None
 0.82A 3uboB-3hbaA:
3.8		 3uboB-3hbaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 5 HIS A  54
LEU A 209
LEU A 206
ASP A 257
 None
 1.06A 4aqlA-3hbaA:
undetectable		 4aqlA-3hbaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 4 ALA A 184
ALA A 187
ALA A 188
ALA A 191
 None
 0.13A 4oaeA-3hbaA:
undetectable		 4oaeA-3hbaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 11 ASP A 104
GLN A 108
ALA A 109
VAL A  47
ASP A  53
 None
 1.11A 4uuuA-3hbaA:
undetectable
4uuuB-3hbaA:
undetectable		 4uuuA-3hbaA:
19.16
4uuuB-3hbaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 11 ASP A 104
GLN A 108
ALA A 109
VAL A  47
ASP A  53
 None
 1.11A 4uuuB-3hbaA:
undetectable		 4uuuB-3hbaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 7 TYR A 306
VAL A 258
ILE A 260
LEU A 185
 None
 0.95A 4xo7A-3hbaA:
undetectable		 4xo7A-3hbaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_B_ACTB505_0
(ADENOSYLHOMOCYSTEINA
SE)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		4 / 4 ASP A 308
ILE A 307
ARG A  12
ARG A 304
 None
 1.40A 5m67B-3hbaA:
2.9		 5m67B-3hbaA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE
(Shewanella
denitrificans) 		5 / 12 LEU A  22
SER A 173
ILE A 296
HIS A 293
LEU A 161
 None
 1.34A 6djzB-3hbaA:
undetectable		 6djzB-3hbaA:
20.94